Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 5 34-5, 1996, Pages

  Green, A L ^b   Hultman, E ^b   Macdonald, I A ^b   Sewell, D A ^b   Greenhaff, P L ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b NONE

Author keywords

glucose; insulin; phosphocreatine

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBOHYDRATE; CREATINE; CREATINE PHOSPHATE; GLUCOSE; INSULIN;

ADULT; ARTICLE; CARBOHYDRATE INTAKE; DIET SUPPLEMENTATION; EXERCISE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; MALE; MUSCLE BIOPSY; MUSCLE METABOLISM; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0029830531     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.5.e821     Document Type: Article

References (21)

1. Balsom, P., B. Ekblom, K. Süderlund, B. Sjüdin, and E. Hultman. Creatine supplementation and dynamic high-intensity intermittent exercise. Scand. J. Med. Sci. Sports 3: 143-149, 1993.
2. Baron, A., H. Steinberg, H. Chaker, R. Learning, A. Johnson, and G. Brechtel. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J. Clin. Invest. 96: 786-792, 1995.
3. Bergstrüm, J. Muscle electrolytes in man. Determined by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients and patients with chronic diarrhoea. Scand. J. Clin. Invest. 14: 1-110, 1962.
4. Bessman, S., and A. Fonyo. The possible role of mitochondrial bound creatine kinase in regulation of mitochondrial respiration. Biochem. Biophys. Res. Commun. 22: 597-602, 1966.
5. Birch, R., D. Noble, and P. L. Greenhaff. The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. Eur. J. Appl. Physiol. Occup. Physiol. 69: 268-270, 1994.
6. Casey, A., D. Constantin-Teodosiu, S. Howell, E. Hultman, and P. L. Greenhaff. Creatine supplementation favorably affects performance and muscle metabolism during maximal exercise in humans. Am. J Physiol. 271 (Endocrinol. Metab. 34): E31-E37, 1996.
7. Chasiotis, D. The regulation of glycogen phosphorylase and glycogen breakdown in human skeletal muscle. Acta Physiol. Scand. Suppl 518: 1-68, 1983.
8. Dunnett, M., R. C. Harris, and C. E. Orme. Reverse-phase ion-pairing high-performance liquid chromatography of phosphocreatine, creatine and creatinine in equine muscle. Scand. J. Clin. Lab. Invest. 51: 137-141, 1991.
9. Gallen, I. W., and I. A. Macdonald. Effect of two methods of heating on body temperature, forearm blood flow, and deep venous oxygen saturation. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E639-E643, 1990.
10. Gilbert, C., K. M. Kretzschmar, D. R. Wilkie, and R. C. Woledge. Chemical change and energy output during muscular contraction. J. Physiol. Lond. 218: 163-193, 1971.
11. Green, A. L., E. J. Simpson, J. J. Littlewood, I. A. Macdonald, and P. L. Greenhaff. Carbohydrate ingestion augments creatine retention during creatine feeding. Acta Physiol. Scand. In press.
12. Greenhaff, P. L. K. Bodin, K. Súderlund, and E. Hultman. The effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E725-E730, 1994.
13. Greenhaff, P. L., A. Casey, A. H. Short, R. C. Harris, K. Süderlund, and E. Hultman. The influence of oral creatine supplementation on muscle torque during repeated bouts of maximal voluntary exercise in man. Clin. Sci. Lond. 84: 565-571, 1993.
14. Harris, R. C., E. Hultman, and L.-O. Norjesü. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of the musculus quadriceps femoris of man at rest. Methods and variance of values. Scand. J. Clin. Lab. Invest. 33: 109-120, 1974.
15. Harris, R. C., K. Süderlund, and E. Hultman. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. Lond. 83: 367-374, 1992.
16. Haughland, R. B., and D. T. Chang. Insulin effects on creatine transport in skeletal muscle. Proc. Soc. Exp. Biol. Med. 148: 1-4, 1975.
17. 14C by skeletal muscle in normal and X-irradiated rats. Proc. Soc. Exp. Biol. Med. 139: 1265-1271, 1972.
18. Larner, J. Mediators of post-receptor action of insulin. Am. J. Med. 74: 38-51, 1983.
19. Levin, R. Insulin: the effects and mode of action of the hormone. In: Vitamins and Hormones, edited by P. L. Munson, E. Diczfalusy, J. Glover, and R. Olson. New York: Academic, 1982, p. 145-173.
20. Süderlund, K., and E. Hultman. Effects of delayed freezing on content of phosphagens in human skeletal muscle biopsy samples. J. Appl. Physiol. 61: 832-835, 1986.
21. Walker, J. B. Creatine: biosynthesis, regulation, and function. Adv. Enzymol. Relat. Areas Mol. Med. 50: 177-242, 1979.