Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations

Journal of Biological Chemistry

Volumn 273, Issue 29, 1998, Pages 18210-18219

  Watkins, Paul A ^a,b   Lu, Jyh Feng ^a   Steinberg, Steven J ^a   Gould, Stephen J ^a   Smith, Kirby D ^a   Braiterman, Lelita T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CERULENIN; FATTY ACID TRANSPORTER; GLUCOSE; LONG CHAIN FATTY ACID COENZYME A LIGASE; OLEIC ACID; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

ARTICLE; FATTY ACID METABOLISM; FUNGUS GROWTH; MICROSOME; MITOCHONDRION; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ADRENOLEUKODYSTROPHY; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; COENZYME A LIGASES; CONSERVED SEQUENCE; DATABASES, FACTUAL; DNA, FUNGAL; FATTY ACIDS; HOMEOSTASIS; MICROBODIES; MOLECULAR SEQUENCE DATA; OLEIC ACID; OPEN READING FRAMES; RATS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0032540894     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.29.18210     Document Type: Article

References (58)

1. Watkins, P. A. (1997) Prog. Lipid Res. 36, 55-83
2. Singh, H., and Poulos, A. (1988) Arch. Biochem. Biophys. 266, 486-495
3. Lazo, O., Contreras, M., Hashmi, M., Stanley, W., Irazu, C., and Singh, I. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7647-7651
4. Kalish, J. E., Chen, C. I., Gould, S. J., and Watkins, P. A. (1995) Biochem. Biophys. Res. Commun. 206, 335-340
5. Moser, H. W., Smith, K. D., and Moser, A. B. (1995) in The Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) pp. 2325-2349, McGraw-Hill Inc., New York
6. Wanders, R. J. A., van Roermund, C. W. T., van Wijland, M. J. A., Schutgens, R. B. H., van den Bosch, H., Schram, A. W., and Tager, J. M. (1988) Biochem. Biophys. Res. Commun. 153, 618-624
7. Mosser, J., Douar, A. M., Sarde, C. O., Kioschis, P., Feil, R., Moser, H., Poustka, A. M., Mandel, J. L., and Aubourg, P. (1993) Nature 361, 726-730
8. Kok, F., Neumann, S., Sarde, C. O., Zheng, S., Wu, K. H., Wei, H. M., Bergin, J., Watkins, P. A., Gould, S. J., Moser, H. W., Mandel, J. L. and Smith, K. D. (1995) Hum. Mutat. 6, 104-115
9. Braiterman, L. T., Zheng, S., Watkins, P. A., Geraghty, M. T., Johnson, G., McGuinness, M. C., Moser, A. B., and Smith, K. D. (1998) Hum. Mol. Genet. 7, 239-247
10. Cartier, N., Lopez, J., Moullier, P., Rocchiccioli, F., Rolland, M. O., Jorge, P., Mosser, J., Mandel, J. L., Bougneres, P. F., Danos, O., and Aubourg, P. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1674-1678
11. Shimozawa, N., Tsukamoto, T., Suzuki, Y., Orii, T., Shirayoshi, Y., Mori, T., and Fujiki, Y. (1992) Science 255, 1132-1134
12. Dodt, G., Braverman, N., Wong, C., Moser, A., Moser, H. W., Watkins, P., Valle, D., and Gould, S. J. (1995) Nat. Genet. 9, 115-125
13. Yahraus, T., Braverman, N., Dodt, G., Kalish, J. E., Morrell, J. C., Moser, H. W., Valle, D., and Gould, S. J. (1996) EMBO J. 15, 2914-2923
14. Braverman, N., Steel, G., Obie, C., Moser, A., Moser, H., Gould, S. J., and Valle, D. (1997) Nat. Genet. 15, 369-376
15. Chang, C. C., Lee, W. H., Moser, H., Valle, D., and Gould, S. J. (1997) Nat. Genet. 15, 385-388
16. Reuber, B. E., Germain-Lee, E., Morrell, J. C., Geisbrecht, B., Collins, C., Ameritunga, R., Moser, H. W., Valle, D., and Gould, S. J. (1997) Am. J. Hum Genet. 61, (suppl.) A54
17. Knoll, L. J., Johnson, D. R., and Gordon, J. I. (1994) J. Biol. Chem. 269, 16348-16356
18. Johnson, D. R., Knoll, L. J., Levin, D. E., and Gordon, J. I. (1994) J. Cell Biol. 127, 751-762
19. Uchida, Y., Kondo, N., Orii, T., and Hashimoto, T. (1996) J. Biochem. (Tokyo) 119, 565-571
20. Uchiyama, A., Aoyama, T., Kamijo, K., Uchida, Y., Kondo, M., Orii, T., and Hashimoto, T. (1996) J. Biol. Chem. 271, 30360-30365
21. Schaffer, J. E., and Lodish, H. F. (1994) Cell 79, 427-436
22. Faergeman, N. J., DiRusso, C. C., Elberger, A., Knudsen, J., and Black, P. N. (1997) J. Biol. Chem. 272, 8531-8538
23. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410
24. Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E., Li, J., Hieter, P., and Boeke, J. D. (1998) Yeast 14, 115-132
25. Crane, D. I., Kalish, J. E., and Gould, S. J. (1994) J. Biol. Chem. 269, 21835-21844
26. Sherman, F., Fink, G. R., and Hicks, J. B. (1979) Methods in Yeast Genetics, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
27. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
28. Elgersma, Y., Vos, A., van den Berg, M., van Roermund, C. W., van der Sluijs, P., Distel, B., and Tabak, H. F. (1996) J. Biol. Chem. 271, 26375-26382
29. Lorenz, M. C., Muir, R. S., Lim, E., McElver, J., and Weber, S. C. (1995) Gene (Amst.) 158, 113-117
30. Erdmann, R., and Blobel, G. (1995) J. Cell Biol. 128, 509-523
31. Singh, I., Pahan, K., Dhaunsi, G. S., Lazo, O., and Ozand, P. (1993) J. Biol. Chem. 268, 9972-9979
32. Watkins, P. A., Ferrell, E. V., Jr., Pedersen, J. I., and Hoefler, G. (1991) Arch. Biochem. Biophys. 289, 329-336
33. Dole, V. P. (1956) J. Clin. Invest. 35, 150-154
34. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
35. Miller, G. L. (1959) Anal. Chem. 31, 964
36. Folch, J., Lees, M., and Sloane-Stanley, G. H. (1957) J. Biol. Chem. 226, 457-509
37. Moser, H. W., and Moser, A. B. (1991) in Techniques in Diagnostic Human Biochemical Genetics (Hommes, F. A., ed) pp. 177-191, Wiley-Liss, New York
38. Gould, S. J., Keller, G. A., Schneider, M., Howell, S. H., Garrard, L. J., Goodman, J. M., Distel, B., Tabak, H., and Subramani, S. (1990) EMBO J. 9, 85-90
39. Knoll, L. J., Johnson, D. R., and Gordon, J. I. (1995) J. Biol. Chem. 270, 10861-10867
40. Einerhand, A. W. C., Kos, W. T., Distel, B., and Tabak, H. F. (1993) Eur. J. Biochem. 214, 323-331
41. Wang, T., Luo, Y., and Small, G. M. (1994) J. Biol. Chem. 269, 24480-24485
42. Ho, J. K., Moser, H., Kishimoto, Y., and Hamilton, J. A. (1995) J. Clin. Invest. 96, 1455-1463
43. Knazek, R. A., Rizzo, W. B., Schulman, J. D., and Dave, J. R. (1983) J. Clin. Invest. 72, 245-248
44. Whitcomb, R. W., Linehan, W. M., and Knazek, R. A. (1988) J. Clin. Invest. 81, 185-188
45. Hettema, E. H., van Roermund, C. W. T., Distel, B., van den Berg, M., Vilela, C., Rodrigues-Pousada, C., Wanders, R. J. A., and Tabak, H. F. (1996) EMBO J. 15, 3813-3822
46. Lombard-Platet, G., Savary, S., Sarde, C. O., Mandel, J. L. and Chimini, G. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1265-1269
47. Kamijo, K., Taketani, S., Yokota, S., Osumi, T., and Hashimoto, T. (1990) J. Biol. Chem. 265, 4534-4540
48. Shani, N., Steel. G., Dean, M., and Valle, D. (1996) Mol. Biol. Cell 7, (suppl.) 433a
49. Shani, N., Watkins, P. A., and Valle, D. (1994) Am. J. Hum. Genet. 55, (suppl.) A138
50. Shani, N. and Valle, D. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 11901-11906
51. Dieckmann, R., Lee, Y. O., Vanliempt, H., Vondohren, H., and Kleinkauf, H. (1995) FEBS Lett. 357, 212-216
52. Steinberg, S. J., Kemp, S., Braiterman, L., and Watkins, P. A. (1997) Am. J. Hum. Genet. 61, (suppl.) A262
53. Black, P. N., Zhang, Q., Weimar, J. D., and DiRusso, C. C. (1997) J. Biol. Chem. 272, 4896-4903
54. Watkins, P. A., McGuinness, M. C., Raymond, G. V., Hicks, B. A., Sisk, J. M., Moser, A. B., and Moser, H. W. (1995) Ann. Neurol. 38, 472-477
55. Suzuki, H., Kawarabayasi, Y., Kondo, J., Abe, T., Nishikawa, K., Kimura, S., Hashimoto, T., and Yamamoto, T. (1990) J. Biol. Chem. 265, 8681-8685
56. Fujino, T., and Yamamoto, T. (1992) J. Biochem. (Tokyo) 111, 197-203
57. Fujino, T., Kang, M.-J., Suzuki, H., Iijima, H., and Yamamoto, T. (1996) J. Biol. Chem. 271, 16748-16752
58. Abe, T., Fujino, T., Fukuyama, R., Minoshima, S., Shimizu, N., Toh, H., Suzuki, H., and Yamamoto, T. (1992) J. Biochem. (Tokyo) 111, 123-128