Aging, cancer, and wound healing

In Vivo

Volumn 14, Issue 1, 2000, Pages 83-92

  Kudravi, Steven A ^a   Reed, May J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Aging; Cancer; Estrogen; Growth factors; IGF; TGF 1; VEGF; Wound healing

Indexed keywords

DNA; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR;

AGING; APOPTOSIS; CANCER; CELL CYCLE; GENE EXPRESSION; HUMAN; REVIEW; SENESCENCE; WOUND HEALING;

EID: 0034108587     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (113)

1. Hayflick L: How and why we age. Exper Gerontol 33: 639-653, 1998.
2. Riabowol K: Transcription factor activity during cellular aging of human diploid fibroblasts. Biochem Cell Biol 70: 1064-1072, 1993.
3. Helenius M, Hanninen M, Lehtinen S, Salminen A: Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J 318: 603-608, 1996.
4. Kanazawa S, Fujiwara Y, Mizuno K: Selective repression of growth regulating cdk2 cyclin E And E2F1 genes in human cell senescence. Kobe J Med Sci 40: 165-174, 1994.
5. Garkavtsev I, Hull C, Riabowol K: Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence. Exper Gerontol 33: 81-94, 1998.
6. Noda A, Ning Y, Venable S , Periera-Smith O, Smith J: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211: 90-98, 1994.
7. Buckbinder L, Talbott R, Velasco-Miguel S, et al: Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377: 646-649, 1995.
8. Gire V and Wynford-Thomas D: Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol Cell Biol 18: 1611-1621, 1998.
9. Wright WE, Periera-Smith OM, Shay JW: Reversible cellular senescence: implications for immortalisation of normal human diploid fibroblasts. Mol Cell Biol 9: 3088-3092, 1989.
10. Mera S: The role of telomeres in ageing and cancer. Br JBiomed Sci 55: 221-225, 1998.
11. Vaziri H, Squire J, Pandita T, Bradley G, Kuba R, Zhang H, Gulyas S, Hill R, Nolan G, Benchimol S: Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol Cell Biol 19: 2373-2379, 1999.
12. Singer A, Clark R: Cutaneous wound healing. NEJM341 738-746, 1999.
13. Khorramizadeh M, Tredget E, Telasky C, Shen Q, Ghahary A: Aging differentially modulates the expression of collagen and collagenase in dermal fibroblasts. Mol Cell Biochem 194: 99-108, 1999.
14. Phillips G, Stone A, Schultz J, Jones B, Knighton D: Proliferation of wound derived capillary endothelial cells: young versus aged. Mech Ageing Dev 77: 141-148, 1994.
15. Arthur W, Vernon R, Sage E, Reed M: Growth factors reverse the impaired sprouting of microvessels from aged mice. Microvasc Res 55: 260-270, 1998.
16. Reed M, Corsa A, Pendergrass W, Penn P, Sage E, Abrass I: Neovascularization in aged mice: delayed angiogenesis is coincident with decreased levels of transforming growth factor β1 and type I collagen. Am J Pathol 152: 113-23, 1998.
17. Rivard A, Fabre J-E, Silver M, Chen D, Murohara T, Kearney M, Magner M, Asahara T, Isner J: Age-dependent impairment of angiogenesis. Circulation 99: 111-120, 1999.
18. Sonntag W, Lynch C, Cooney P, Hutchins P: Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor-I. Endocrinology 138: 3515-3520, 1997.
19. Dreosti I: Nutrition cancer and aging. Ann N YAcad Sci 854: 371-377, 1998.
20. Ershler W: Explanations for reduced tumor proliferative capacity with age. Exp Gerontology 27: 551-558, 1992.
21. Wynford-Thomas D: Cellular senescence and cancer. J Path 187: 100-111, 1999.
22. Dvorak HF: Tumors: wounds that do not heal. 1 315: 1650-1659, 1986.
23. Rudman D, Feller A, Nagraj H, Gergans G, Lalitha P, et al: Effects of human growth hormone in men over 60 years old. NEJM 323: 1-6, 1990.
24. Halloway L, Butterfield G, Hintz R, Gesundheit N, Marcus R: Effect of recombinant human growth hormone on metabolic indices body composition and bone tumour in healthy elderly women. J Clin Endocrinol Metab 79: 470-479, 1994.
25. Wang J, Zhou J, Powell-Braxton L, Bondy C: Effects of IGF1 gene deletion on postnatal growth patterns. Endocrinology 140: 3391-3394, 1999.
26. Arvat E, Ceda G, Ramunni J, Lanfranco F, Aimaretti G, Gianotti L, Broglio F, Ghigo E: The IGF-I response to very low rhGH doses is preserved in human ageing. Clin Endocrinol (Oxf) 49: 757-763, 1998.
27. Gucev Z, Oh Y, Kelley K, et al: Insulin-like growth factor binding protein 3 mediates retinoic acid and transforming growth factor β2-induced growth inhibition in human breast cancer cells. Cancer Res 56: 1545-1550, 1996.
28. Juul A, Main K, Blum W, Lindholm J, Ranke M, Skakkebaek N: The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP- 1 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients. Clin Endocrinol (Oxf) 41: 85-93, 1994.
29. Nakamura M, Chikama T, Nishida T: Up-regulation of integrin alpha 5 expression by combination of substance P and insulin-like growth factor-1 in rabbit corneal epithelial cells. Biochem Biophys Res Commun 246: 777-782, 1998.
30. Toung J, Ogle R, Morgan R, Lindsey W: Insulin-like growth factor 1- and 2- augmented collagen gel repair of facial osseous defects. Arch Otolaryngol Head Neck Surg 125: 451-455, 1999.
31. Watanabe S, Wang X, Hirose M, Kivilioto T, Osada T, Miwa H, Oide H, Kitamura T, Yoneta T, Seto K, Sato N: Insulin-like growth factor I plays a role in gastric wound healing: evidence using a zinc derivative polaprezinc and an in vitro rabbit wound repair model. Aliment Pharmacol Ther 12: 1131-1138, 1998.
32. Ferber A, Chang C, Sell C, Ptasznik A, Cristofalo V, Hubbard K, Ozer H, Adamo M, Roberts C, Jr LeRoith D, et al: Failure of senescent human fibroblasts to express the insulin-like growth factor-I gene. JBiol Chem 268: 17883-17888, 1993.
33. Gartner M, Benson J, Caldwell M: Insulin-like growth factors I and II expression in the healing wound. J Surg Res 52: 389-394, 1992.
34. Vogt P, Lehnhardt M, Wagner D, Jansen V, Krieg M, Steinau H: Determination of endogenous growth factors in human wound fluid: temporal presence and profiles of secretion. Plast Reconstr Surg 102: 117-123, 1998.
35. Jeschke M, Barrow R, Hawkins H, Yang K, Hayes R, Lichtenbelt B, Perez- Polo J, Herndon D: IGF-I gene transfer in thermally injured rats. Gene Ther 6: 1015-1020, 1999.
36. Pierre E, Perez-Polo J, Mitchell A, Matin S, Foyt H, Herndon D: Insulin- like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing. J Burn Care Rehabil 18: 287-291, 1997.
37. Tsuboi R, Shi C, Sato C, Cox G, Ogawa H: Co-administration of insulin- like growth factor (IGF-I and IGF-binding protein-1 stimulates wound healing in animal models. J Invest Dermatol 104: 199-203, 1995.
38. Andresen J, Ehlers N: Chemotaxis of human keratocytes is increased by platelet- derived growth factor-BB, epidermal growth factor transforming growth factor-alpha, acidic fibroblast growth factor insulin-like growth factor-I, and transforming growth factor-β. Curr Eye Res 17: 79-87, 1998.
39. Grigoriev V, Moerman E, Goldstein S: Overexpression of insulin-like growth factor binding protein-3 by senescent human fibroblasts: attentuation of the mitogenic response to IGF-1. Exp Cell Res 219: 315-321, 1995.
40. Oh Y: IGF-independent regulation of breast cancer growth by IGF binding proteins. Breast Canc Res Treat 47: 283-293, 1998.
41. Rajah R, Valentinis B, Cohen P: Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53 and IGF-independent pathway. J Biol Chem 272: 12181-12188, 1997.
42. Furlinetto R, Harwell S, Frick K: Insulin-like growth factor-I induces cyclin D1 expression in MG63 human osteosarcoma cells in vitro. Mol Endocrinol 8: 510-517, 1994.
43. Parrizas M, LeRoith D: Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product. Endocrin 138: 1355-1358, 1997.
44. Fowlkes J, Serra D, Nagase H, Thrailkill K: MMPs are IGFBP-degrading proteinases: implications for cell proliferation and tissue growth. Ann N YAcad Sci 878: 696-699, 1999.
45. Manes S, Mira E, Barbacid M, Cipres A, Fernandez-Resa P, Buesa J, Merida I, Aracil M, Marquez G, Martinez A: Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3. J Biol Chem 272: 25706-25712, 1997.
46. Wang Y, Wong Y: Sex hormone-induced prostatic carcinogenesis in the noble rat: the role of insulin-like growth factor-I and vascular endothelial growth factor in the development of prostate cancer. Prostate 35 165-177, 1998.
47. Grant M, Jerdan J, Merimee T: Insulin-like growth factor-I modulates endothelial cell chemotaxis. J Clin Endocrin Metab 65: 370-371, 1987.
48. King G, Goodman A, Bosnex S, Moses A, Kahn C: Receptors and growth promoting effects of insulin and IGF-I on cells from bovine retinal capillaries and aorta. J Clin Invest 75: 1028-1035, 1985.
49. Hyer S, Sharp P, Brooks R, Burrin J, Kohner E: A two-year follow-up study of serum insulin-like growth factor-I in diabetes with retinopathy. Metabolism 38: 586-589, 1989.
50. Ghahary A, Shen Q, Shen Y, Scott P, Tredget E: Induction of transforming growth factor β1 by insulin-like growth factor-I in dermal fibroblasts. J Cell Physiol 174: 301-309, 1998.
51. Akagi Y, Liu W, Zebrowski B, Xie K, Ellis E: Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res 58: 4008-14, 1998.
52. Goad D, Rubin J, Wang H, Tashjian AJ, Patterson C: Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. Endocrinology 137: 2262-2268, 1996.
53. Kim K, Bae S, Lee O, Bae M, Lee M, Park B: Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Cancer Res 58: 348-351, 1998.
54. DeLarco J, Todaro G: Sarcoma growth factor (SGF): specific binding to epidermal growth factor (EGF) membrane receptors. J Cell Phys 102: 267-277, 1980.
55. Ashcroft G, Horan M, Ferguson M: The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model. J Anat 190: 351-365, 1997.
56. Gazit D, Zilberman Y, Ebner R, Kahn A: Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-β. J Cell Biochem 70: 478-488, 1998.
57. Mori Y, Hatamochi A, Arakawa M, Ucki H: Reduced expression of mRNA for transforming growth factor beta (TGF beta) and TGF β receptors I and II and decreased TGF binding to the receptors in in vitro-aged fibroblasts. Arch Dermatol Res 290: 158-162, 1998.
58. Wei X, Messner K: Age- and injury-dependent concentrations of transforming growth factor-β1 and proteoglycan fragments in rabbit knee joint fluid. Osteoarthritis Cartilage 6: 10-18, 1998.
59. Fajardo L, Prionas S, Kwan H, Kowalski J, Allison A: Transforming growth factor B 1 induces angiogenesis in vivo with a threshold pattern. Lab Invest 74: 600-608, 1996.
60. Reed M, Vernon R, Abrass I, Sage E: TGF-β1 induces the expression of type I collagen and SPARC and enhances contraction of collagen gels by fibroblasts from young and aged donors. J Cell Phys 158: 169-179, 1994.
61. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K: Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 269: 6271-6274, 1994.
62. Dickson M, Martin J, Cousins F, Kulkarmi A, Karlsson S, Ankhurst R: Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knockout mice. Development 121: 1845-1854, 1995.
63. Heimark R, Twardzik D, Schwartz S: Inhibition of endothelial regeneration by type-β transforming growth factor from platelets. Science 233: 1078-1080, 1986.
64. Basson C, Kocher O, Basson M, Asis A, Madri J: Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF-β1 correlates with reciprocal effects on cell migration. J Cell Phys 153: 118-128, 1992.
65. Sato Y, Rifkin D: Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta I-like molecule by plasmin during co-culture. J Cell Biol 109: 309-315, 1989.
66. Ashcroft G, Dodsworth J, van Boxtel E, Tarnuzzer R, Horan M, Schultz G, Ferguson M: Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels. Nat Medicine 3: 1209-1215, 1997.
67. Beck L, DeGuzman L, Lee W, Xu Y, Siegal M, Amento E: One sytemic administration of transforming growth factor-β1 reverses age- or glucocorticoid- impaired wound healing. J Clin Invest 92: 2841-2849, 1993.
68. Puolakkainen P, Reed M, Gombotz W, Twardzik D, Abrass I, Sage E: Acceleration of wound healing in aged rats by topical application of transforming growth factor-β. Wound Rep Reg 3: 330-339, 1995.
69. Wu L, Xia Y, Roth S, Gruskin E, Mustoc T: Transforming growth factor-β1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol 154: 301-319, 1999.
70. Pierce G, Mustoe T, Lingelbach J, Masakowski V, Griffin G, Senior R, et al: Platelet-derived growth factor and transforming growth factor-β enhance tissue repair activities by unique mechanisms. J Cell Biol 109: 429-440, 1989.
71. Polverini P, Leibovich S: Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor associated macrophages. Lab Invest 51: 1984.
72. Ueki N, Nakazato M, Ohkawa T, Ikeda T, Amuro Y, Hada T, Higashino K: Excessive production of transforming growth factor-β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth. Biochim Biophys Acta 1137: 189-196, 1992.
73. Baldwin R, Kore M: Growth inhibition of human pancreatic carcinoma cells by transforming growth factor β1. Growth Factors 8: 23-34, 1993.
74. Cui W, Fowlis D, Bryson S, et al: TGF β1 inhibits the formation of benign skin tumors but enhances progression to invasive spindle cell carcinomas in transgenic mice. Cell 86: 531-542, 1996.
75. Khosla S, Oursler M, Schroeder M, Eberhardt N: Transforming growth factor β1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels. Endocrin 135: 1887-1893, 1994.
76. Tang B, Bottinger E, Jakowlew S, et al: Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency. Nature Med 4: 802-807, 1998.
77. Miyazaki M, Ohashi R, Tsuji T, Mihara K, Gohda E, Namba M: Transforming growth factor-beta 1 stimulates or inhibits cell growth via down- or up-regulation of p21/Waf1. Biochem Biophys Res Commun 246: 873-80, 1998.
78. Kang S, Bang Y, Jong H, Seo J, Kim N, Kim S: Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells. Br J Cancer 80: 1144-1149, 1999.
79. Kornmann M, Tangvoranuntakul P, Korc M: TGF-β-1 up-regulates cyclin D1 expression in colo-357 cells whereas suppression of cyclin D1 levels is associated with down- regulation of the type I TGF-β receptor. Int J Cancer 83: 247-254, 1999.
80. Ewen M: p53-dependent repression of cdk4 synthesis in transforming growth factor 6-induced cell cycle arrest. Cell 128: 355-360, 1996.
81. Reynisdottir I, Polyak K, Iavarone A, Massague J: Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev 9: 1831-1845, 1995.
82. Haufel T, Dormann S, Hanusch J, Schwieger A, Bauer G: Three distinct roles for TGF-β during intercellular induction of apoptosis: a review. Anticanc Res 19: 105-112, 1999.
83. Portella G, Cumming S, Liddell J, et al: Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinomas. Cell Growth Differe 9: 393-404, 1998.
84. Mandriota S, Menoud P-A, Pepper M: Transforming growth factor β1 downregulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. J Biol Chem 271: 11500-11505, 1996.
85. Weller M, Fontana A: The failure of current immunotherapy for malignant glioma. Tumor derived TGF-β T-cell apoptosis and the immune priveledge of the brain. Brain Res Rev 21: 128-151, 1995.
86. Wilson M: Regulation of the growth hormone-insulin-like growth factor I axis in developing and adult monkeys is affected by estradiol replacement and supplementation with insulin-like growth factor-I. J Clin Endocrin Metab 83: 2018-2028, 1998.
87. Issa J, Ottaviano Y, Celano P, Hamilton S, Davidson N, Baylin S: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7: 536-540, 1994.
88. Issa J, Vertino P, Boehm C, Newsham I, Baylin S: Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci USA 93: 11757-11762, 1996.
89. Calvin M, Dyson M, Rymer J, Young S: The effects of ovarian hormone deficiency on wound contraction in a rat model. Br J Obst Gyn 105: 223-227, 1998.
90. Banerjee S, Sarkar D, Weston A, De A, Campbell D: Over expression of vascular endothelial growth factor and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesis. Carcinogenesis 18: 1155-1161, 1997.
91. Banerjee S, Campbell D, Weston A, Banerjee D: Biphasic estrogen response on bovine capillary adrenal medulla capillary endothelial cells adhesion proliferation and tube formation. Mol Cell Biochem 177: 97-105, 1997.
92. Greb R, Heikinheimo O, Williams R, Hodgen G, Goodman A: Vascular endothelial growth factor in primate endometrium is regulated by oestrogen-receptor and progesterone-receptor ligands in vivo. Human Reproduction 12: 1280-1292, 1997.
93. Krasinski K, Spyridopoulos I, Asahara T, van der Zee R, Isner J, Losordo D: Estradiol accelerates functional endothelial recovery after arterial injury. Circulation 95: 1768-1772, 1997.
94. Nakamura J, Savinov A, Lu Q, Brodie A: Estrogen regulates vascular endothelial growth/permeability factor expression in 7.12-dimethylbenz(a)anthracene-induced rat mammary tumors. Endocrinology 137: 5589-5596, 1996.
95. Shifren J, Tseng J, Zaloudek C, Ryan I, Meng Y, Ferrara N, Jaffe R, Taylor R: Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrin Metab 81: 3112-3118, 1996.
96. McLaren J, Prentice A, Charnock-Jones D, Millican S, Muller K, Sharkey A, Smith S: Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J Clin Invest 98: 482-489, 1996.
97. Isaksson E, Cline J, Skoog L, Soderqvist G, Wilking N, von Schoultz E, von Schoultz B: p53 expression in breast and endometrium during estrogen and tamoxifen treatment of surgically postmenopausal cynomolgus macaques. Breast Cancer Res Treat 53: 61-67, 1999.
98. Ceccarelli C, Santini D, Chieco P, Taffurelli M, Gamberini M, Pileri S, Marrano D: Retinoblastoma (RBI) gene product expression in breast carcinoma. Correlation with Ki-67 growth fraction and biopathological profile. J Clin Pnthol 51: 818-824, 1998.
99. Broet P, Spyratos F, Romain S, Quillien V, Daver A, Ricolleau G, Rallet A, Toulas C, Asselain B: Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: a multicentre study. Br J Cancer 80: 536-45, 1999.
100. Marinho A, Soares R, Ferro J, Lacerda M, Schmitt F: Angiogenesis in breast cancer is related to age but not to other prognostic parameters. Pathol Res Pract 193: 267-273, 1997.
101. Ferrara N, Davis-Smyth T: The biology of vascular endothelial growth factor. Endocrin Reviews 18: 4-18, 1997.
102. Edelman J, Castro M, Wen Y: Correlation of VEGF expression by leukocytes with the growth and regression of blood vessels in the rat cornea. Invest Ophthalmol & Vis Sci 40: 1112-1123, 1999.
103. Wang D, Yamazaki K, Nohtomi K, Shizume K, Ohsumi K, Shibuya M, Demura H, Sato K: Increase of vascular endothelial growth factor mRNA expression by 125-dihydroxyvitamin D3 in human osteoblast-like cells. J Bone Miner Res 11: 472-479, 1996.
104. Ambs S, Merriam W, Ogunfusika M, Bennett W, Ishibe N, Hussain S, Tzeng E, Geller D, Billiar T, Harris C: p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells. Nat Med 4: 1371-1376, 1998.
105. Tsukamoto A, Kaneko Y, Yoshida T, Ichinose M, Kimura S: Regulation of angiogenesis in human hepatomas: possible involvement of p53-inducible inhibitor of vascular endothelial cell proliferation. Cancer Lett 14179-84, 1999.
106. Watanabe Y, Lee S, Detmar M, Ajioka I, Dvorak H: Vascular permeability/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogenc 14: 2025-2032, 1997.
107. Agani F, Kirsch D, Friedman S.-Kastan M, Semenza G: p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. Cancer Res 57: 4474-4477, 1997.
108. Arii S, Mori A, Uchida S, Fujimoto K, Shimada Y, Imamura M: Implication of vascular endothelial growth factor in the development and metastasis of human cancers. Hum Cell 12: 25-30, 1999.
109. Breier G, Albrecht U, Sterrer S, Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial differentiation. Development 114: 521-532, 1992.
110. Fava R, Olsen N, Spencer-Green G, Yeo K-T, Yeo T-K, Berse B, Jackman R, Senger D, Dvorak H, Brown L: Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180: 341-346, 1994.
111. Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti P, Pan Y-CE, Olander J, Connolly D, Stern D: Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity and promotes monocyte migration. J Exp Med 172: 1535-1545, 1990.
112. Pepper M, Ferrara N, Orci L, Montesano R: Vascular endothelial growth factor induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem & Biophys Res Comm 181: 902-906, 1991.
113. Unemori EN, Ferrara N, Bauer EA, Amento EP: Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153: 557-562, 1992.