Angiogenesis in breast cancer is related to age but not to other prognostic parameters

Pathology Research and Practice

Volumn 193, Issue 4, 1997, Pages 267-273

  Marinho, António ^a   Soares, Raquel ^a   Ferro, Josefo ^a   Lacerda, Manuela ^b   Schmitt, Fernando C ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b Portuguese Cancer Institute   (Portugal)

Author keywords

Angiogenesis; Breast cancer; Factor VIII related antigen; Prognostic factors

Indexed keywords

ESTROGEN RECEPTOR; PROTEIN P53; VON WILLEBRAND FACTOR;

ADULT; AGE; AGED; ANGIOGENESIS; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MICROVASCULATURE; PLOIDY; PROGNOSIS; STAINING; TUMOR VOLUME;

EID: 0030753515     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(97)80003-9     Document Type: Article

References (31)

1. Axelsson K, Ljung BME, Moore-II DH, Thor AD, Chew KL, Edgerton SM, Smith HS, Mayall BH (1995) Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. J Natl Cancer Inst 87: 997-1008.
2. Bartek J, Bartkova J, Vojtesek B, Staskova Z, Rejthar A, Kovarik J, Lane DP (1990) Patterns of expression of the p53 tumor suppressor in human breast tissues and tumors in situ and in vitro. Int J Cancer 46: 839-844
3. Bevilacqua P, Barbareschi M, Verderio P, Boracchi P, Caffo O, Dalla Palma P, Meli S, Weidner N, Gasparini G (1995) Prognostic value of intratumoral microvessel density, a mewasure of tumor angiogenesis, in node negative breast carcinoma-results of a multiparametric study. Breast Cancer Res Treat 36: 205-217
4. Bosari S, Lee AK, DeLellis RA, Wiley BD, Heatley GJ, Silverman ML (1992) Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol. 23: 755-761
5. Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology 19: 403-410
6. Ershler WB (1986) Why tumors grow more slowly in old people. J Natl Cancer Inst 77: 837-839
7. Folkman J (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6
8. Folkman J (1992) The role of angiogenesis in tumor growth. Semin Cancer Biol. 3: 65-71
9. Fox SB, Gatter KC, Bicknell R, Going JJ, Stanton P, Cooke TG, Harris AL (1993) Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res 53: 4161-4163
10. Fox SB, Leek RD, Smith K, Hollyer J, Greenall M, Harris AL (1994) Tumor angiogenesis in node-negative breast carcinomas-relationship with epidermal growth factor receptor, estrogen receptor, and survival. Breast Cancer Res Treat 29: 109-116
11. Fox SB, Turner GDH, Leek RD, Whitehouse RE, Gatter KC, Harris AL (1995) The prognostic value of quantitative angiogenesis in breast cancer and role of adhesion molecule expression in tumor endothelium. Breast Cancer Res Treat 36: 219-226
12. Gasparini G, Harris AL (1995) Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J Clin Oncol 13: 765-782
13. Hall NR, Fish DE, Hunt N, Goldin RD, Guillou PJ, Monson JR (1992) Is the relationship between angiogenesis and metastasis in breast cancer real? Surg Oncol 1: 223-229
14. Herbsman H, Feldman J, Seldera J, Gardner B, Alfonso AE (1981) Survival following breast cancer surgery in the elderly. Cancer 47: 2358-2363
15. Horak ER, Leek R, Klenk N, Lejeune S, Smith K, Stuart N, Greenall M, Stepniewska K, Harris AL (1992) Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet 2340: 1120-1124
16. Kreisle RA, Stebler BA, Ershler WB (1990) Effect of host ase on tumor-associated angiogenesis in mice. J Natl Cancer Inst 82: 44-47
17. Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Dalla Palma P, Barbareschi M (1992) PCNA and Ki-67 expression in breast carcinoma: correlation with clinical and biological variables. J Clin Pathol 45: 416-419
18. Liotta LA, Kleinerman J, Saidel GM (1974) Quantitative relationship of intravascular tumor cells, tumor vessels, and pulmonary metastasis following tumor implantation. Cancer Res 34: 997-1004
19. Liotta LA, Kleinerman J, Saidel GM (1976) The significance of hematogenous tumor cell clumps in the metastatic process. Cancer REs 36: 889-894
20. Miliaras D, Kamas A, Kalekou H (1995) Angiogenesis in invasive breast carcinoma: is it associated with parameters of prognostic significance? Histopathology 26: 165-169
21. O'Reilly MS, Holmgren L, Sshing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J (1994) Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328
22. Schmitt FC, Ferreira MP (1995) MIB-1 is a suitable marker of proliferative activity in formalin-fixed, paraffin-embedded sections of breast cancer. Int J Surg Pathol 2: 287-294
23. Toi M, Kashitani J, Tominaga T (1993) Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int J Cancer 55: 371-374
24. Toi N, Inada K, Suzuki H, Tominaga T (1995) Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Rest Treat 36: 193-204
25. Van Hoef MEHM, Knox WF, Dhesi SS, Howell A, Shor AM (1993) Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer. Eur J Cancer 29A: 1141-1145
26. Vartanian RK, Weidner N (1994) Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. Am J Pathol 144: 1188-1194
27. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G (1992) Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887
28. Weidner N, Semple JP, Welche WR, Folkman J (1991) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. J Engl J Med 324: 1-8
29. Weidner N (1993) Tumor angiogenesis: review of current applications in tumor prognostication. Semin Diagn Pathol 10:302-313
30. World Health Organization Histological typing of breast tumors (1981), 2nd edition. WHO, Geneva
31. Wright C, Angus B, Nicholson S, Sainsbury JRC, Cairns J, Gullick WJ, Kelly P, Harris AL, Wilson Horne CH (1989) Expression of c-erbB-2 concoprotein: a prognostic indicator in human breast cancer. Cancer Res 49: 2087-2090