T Cell Genetic Background Determines Maintenance of IL-2 Signaling: Effects on BALB/c and B10.D2 T Helper Cell Type 1 Phenotype Development

Journal of Immunology

Volumn 159, Issue 4, 1997, Pages 1767-1774

  Güler, Mehmet L ^a   Jacobson, Nils G ^a   Gubler, Ueli ^b   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GAMMA INTERFERON; IL12RB2 PROTEIN, MOUSE; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN RECEPTOR; MESSENGER RNA; STAT4 PROTEIN; STAT4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL CULTURE; GENETICS; METABOLISM; MOUSE; PHENOTYPE; PHOSPHORYLATION; PHYSIOLOGY; SPECIES DIFFERENCE; TH1 CELL;

ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; PHENOTYPE; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RNA, MESSENGER; SPECIES SPECIFICITY; STAT4 TRANSCRIPTION FACTOR; TH1 CELLS; TRANS-ACTIVATORS;

EID: 0031571196     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Mosmann, T. R., H. M. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
2. + T lymphocytes. Immunol. Today 9:268.
3. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead Io different functional properties. Annu. Rev. Immunol. 7:145.
4. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
5. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815.
6. Scott, P., and S. H. E. Kaufmann. 1991. The role of T-cell subsets and cytokines in the regulation of infection. Immunol. Today 12:346.
7. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived lymphokines. Annu. Rev. Immunol. 10:385.
8. Le Gros, G., S. Z. Ben-Sasson, R. A. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 und IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
9. Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
10. Swain, S. L., G. Huston, S. Tonkonogy, and A. D. Weinberg. 1991. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol. 147:2991.
11. Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89:6065.
12. + T cells through IL-12 produced by Listeria-induced macrophages [see comments]. Science 260:547.
13. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. J. Exp. Med. 171:115.
14. Maggi, E., P. Parronchi, R. Manetti, C. Simonelli, M.-P. Piccinni, F. S. Rugiu, M. De Carli, M. Ricci, and S. Romagnani. 1992. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 148:2142.
15. Manetti, R., P. Parronchi, M. G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
16. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
17. Sypek, J. P., C. L. Chung, S. E. H. Mayor, Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin-12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
18. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
19. Belosevic, M., D. S. Finbloom, P. H. Van der Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
20. Hsieh, C. S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181:713.
21. Howard, J. G. 1986. Immunological regulation and control of experimental leishmaniasis. Int. Rev. Exp. Pathol. 28:79.
22. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. J. Exp. Med. 169:59.
23. Scott, P., P. Natovitz, R. L. Coffman, E. Pearce, and A Sher. 1988. Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168:1675.
24. Locksley, R. M., and P. Scott. 1991. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. In Immunoparasitology Today. C. Ash and R. B Gallagher, eds. Elsevier Trends Journals, Amsterdam, U.K., pp. a58-a61.
25. + T cells. J. Immunol. 139:1303.
26. Sadick, M. D., R. M. Locksley, C. Tubbs, and H. V. Raff. 1986. Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro. J. Immunol. 136:655.
27. Shankar, A. H., and R. G. Titus. 1995. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J. Exp. Med. 181:845.
28. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin-12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
29. Scott, P. 1991. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:3149.
30. Bretscher, P. A., G. Wei, J. N. Menon, and H. Bielefeldt-Ohmann. 1992. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 257:539.
31. Titus, R. G., R. Ceredig, J.-C. Cerottini, and J. A. Louis. 1985. Therapeutic effect of anti-L3T4 monoclonal antibody GK 1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J. Immunol. 135:2018.
32. Howard, J. G., C. Hale, and F. Y. Liew. 1981. Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J. Exp. Med. 153:557.
33. Afonso, L. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
34. + T cells curing initiation of infection. J. Exp. Med. 179:447.
35. -. Eur. J. Immunol. 25:3298.
36. + Tcells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. Int. Immunol. 5:1119.
37. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor alpha are co-stimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
38. Guler, M. L., J. D. Gorham, C. S. Hsieh, A. J. Mac-key, R. G. Steen, W. F. Dietrich, and K. M. Murphy. 1996. Genetic susceptibility to leishmania: IL-12 responsiveness in TH1 cell development. Science 271:984.
39. Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C. Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002.
40. + TCR-lo thymocytes in vivo. Science 250: 1720.
41. Marrack, P., R. Shimonkevitz, C. Hannum, K. Haskins, and J. W. Kappler. 1983. The major histocompatibilily complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. J. Exp. Med. 158:1635.
42. + alpha beta-TCR transgenic T cells is macrophage dependent. Int. Immunol. 5:371.
43. Jacobson, N. G., S. J. Szabo, R. M. Weher-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (STAT)3 and STAT4. J. Exp. Med. 181:1755.
44. Szabo, S. J., N. G. Jacobson, A. S. Digne, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665.
45. Tokunaga, K., Y. Nakamura, K. Sakata, K. Fujimori, M. Ohkubo, K. Sawada, and S. Sakiyama. 1987. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res. 47:5616.
46. Yanagida, T., T. Kato, O. Igarashi, T. Inoue, and H. Nariuchi. 1994. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone. J. Immunol. 152:4919.
47. Chua, A. O., V. L. Wilkinson, D. H. Presky, and U. Gubler. 1995. Cloning and characterization of a mouse IL-12 receptor-beta component. J. Immunol. 155: 4286.
48. Szabo, S. J., A. S. Digne, U. Gubler, and K. M. Murphy. 1997. Regulation of the IL-12R beta2 subunit expression in developing Th1 and Th2 cells. J. Exp. Med. 185:817.
49. Wenner, C. A., M. L. Guler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J. Immunol. 156:1442.
50. Cleveland, M. G., J. D. Gorham, T. L. Murphy, E. Tuomanen, and K. M. Murphy. 1996. Lipoteichoic acid preparations of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect. Immun. 64:1906.
51. Wu, C. Y., R. R. Warrier, D. M. Carvajal, A. O. Chua, L. J. Minetti, R. Chizzonite, P. K. A. Mongini, A. S. Stern, U. Gubler, D. H. Presky, and M. K. Gately. 1996. Biological function and distribution of human interleukin-12 receptor beta chain. Eur. J. Immunol. 26:345.
52. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of Jak2 andTYK2: differentia] use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
53. Bacon, C. M., E. F. Petricoin III, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
54. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421.
55. Heinzel, F. P., R. M. Rerko, F. Hatam, and R. M. Locksley. 1993. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150:3924.
56. Behforouz, N. C., C. D. Wenger, and B. A. Mathison. 1986. Prophylactic treatment of BALB/c mice with cyclosporine A and its analog B-5-49 enhances resistance to Leishmania major. J. Immunol. 136:3067.
57. Gorham, J. D., M. L. Guler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Frederick, W. F. Dietrich, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1 T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93:12467.
58. Rogge, L., L. Barberismaino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825.