Regulation of the production of soluble IL-4 receptors in murine cutaneous leishmaniasis. The roles of IL-12 and IL-4

Journal of Leukocyte Biology

Volumn 66, Issue 3, 1999, Pages 481-488

  Fernandez Botran, Rafael ^b   Chilton, Paula M ^a   Hondowicz, Brian D ^a   Vetvickova, Jana ^c   Yan, Jun ^c   Jones III, Walter ^c   Scott, Phillip ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b University of Louisville School of Medicine   (United States)

^c NONE

Author keywords

Cytokine receptors; Immunoregulation; T helper cell subsets

Indexed keywords

ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; RECOMBINANT GAMMA INTERFERON;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOREGULATION; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

EID: 0032845460     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.3.481     Document Type: Article

References (55)

1. Paul, W. E. (1991) Interleukin-4: A prototypic immunoregulatory lymphokine. Blood 77, 1627-1652.
2. Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., Paul, W. E. (1989) Mast cell lines produce lymphokine in response to cross-linkage of Fc∈RI or to calcium ionophores. Nature 339, 64-67.
3. Vitetta, E. S., Fernandez-Botran, R., Myers, C. D., Sanders, V. M. (1989) Cellular interactions in the humoral immune response. Adv. Immunol. 45, 1-105.
4. Finkelmann, F. D., Katona, I. M., Urban Jr., J. F., Beckmann, M. P., Park, L. S., Schooley, K. A., Coffman, R. L., Mosmann, T. R., Paul, W. E. (1990) Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8, 303-333.
5. Swain, S. L., Weinberg, A. D., English, M., Huston, G. (1990) IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145, 3796-3806.
6. Abeshira-Amar, O., Gilbert, M., Joliy, M., Theze, J., Jankovic, D. L. (1992) IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J. Immunol. 148, 3820-3829.
7. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176, 1091-1098.
8. Maher, D. W., Davis, I., Boyd, A. W., Morstyn, G. (1991) Human interleukin-4: An immunomodulator with potential therapeutic applications. Prog. Growth Factor Res. 3, 43-56.
9. Russell, S. M., Keegan, A. D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedmann, M. C., Miyajima, A., Puri, R. K., Paul, W. E., Leonard, W. J. (1993) The interleukin-2 receptor γ chain is a functional component of the interleukin-4 receptor. Science 262, 1880-1883.
10. Kondo, M., Takeshita, T., Ishii, N., Nakamura, M., Watanabe, S., Arai, K., Sugamura, K. (1993) Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262, 1874-1877.
11. Callard, R. E., Matthews, D. J., Hibbert, L. (1996) IL-4 and IL-13 receptors: are they one and the same? Immunol. Today 17, 108-110.
12. Hilton, D. J., Zhang, J.-G., Metcalf, D., Alexander, W. S., Nicola, N. A., Wilson, T. A. (1996) Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93, 497-501.
13. Mosley, B., Beckmann, M. P., March, C. J., Idzerda, R. L, Gimpel, S. D., Vandenbos, T., Friend, D., Alpert, A., Anderson, J., Jackson, J., Wignall, J. M., Smith, C., Gallis, B., Sims, J. E., Urdal, D., Widmer, M. B., Cosman, D., Park, L. S. (1989) The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59, 335-348.
14. Fernandez-Botran, R., Vitetta, E. S. (1990) A soluble, high-affinity interleukin-4-binding protein is present in the biological fluids of mice. Proc. Natl. Acad. Sci. USA 87, 4202-4206.
15. Fanslow, W. C., Clifford, K., VandenBos, T., Teel, A., Armitage, R. J., Beckmann, M. P. (1990) A soluble form of the interleukin-4 receptor in biological fluids. Cytokine 2, 398-401.
16. Wrighton, N., Campbell, L. A., Harada, N., Miyajima, A., Lee, F. (1992) The murine interleukin-4 receptor gene: genomic structure, expression and potential for alternative splicing. Growth Factors 6, 103-118.
17. Maliszewski, C. R., Sato, T. A., Vandenbos, T., Waugh, S., Dower, S. K., Slack, J., Beckmann, M. P., Grabstein, K. H. (1990) Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-4 and IL-4 induced B cell activities in vitro. J. Immunol. 144, 3028-3033.
18. Fanslow, W. C., Clifford, K. N., Park, L. S., Rubin, A. S., Voice, R. F., Beckmann, M. P., Widmer, M. B. (1991) Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor. J. Immunol. 147, 535-540.
19. Sato, T. A., Widmer, M. B., Finkelman, F. D., Madani, H., Jacobs, C. A., Grabstein, K. H., Maliszewski, C. R. (1993) Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo. J. Immunol. 150, 2717-2723.
20. Renz, H., Bradley, K., Enssle, K., Loader, J. E., Larsen, G. L., Gelfand, E. W. (1996) Prevention of the development of immediate hyperresponsivity and airway hyper-responsiveness following in vivo treatment with soluble IL-4 receptor. Int. Arch. Allergy Immunol. 109, 167-176.
21. Gessner, A., Schroppel, K., Will, A., Enssle, K. H., Lauffer, L., Rollinghoff, M. (1994) Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous leishmaniasis. Infect. Immun. 62, 4112-4117.
22. Puccetti, P., Mencacci, A., Cenci, E., Spaccapelo, R., Mosci, P., Enssle, K. H., Romani, L., Bistoni, F. (1994) Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J. Infect. Dis. 169, 1325-1331.
23. Ma, Yuhe, Hurst, H. E., Fernandez-Botran, R. (1996) Soluble cytokine receptors as carrier proteins: the effects of soluble IL-4 receptors on the pharmacokinetics of murine IL-4. J. Pharmacol. Exp. Ther. 279, 340-350.
24. Chilton, P. M., Fernandez-Botran, R. (1993) Production of soluble IL-4 receptors by murine spleen cells is regulated by T cell activation and IL-4. J. Immunol. 151, 5907-5917.
25. Fernandez-Botran, R., Wynn, T. A., Hieny, S., Caspar, P., Chilton, P. M., Sher, A. (1995) Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis. Eur. J. Immunol. 25, 649-656.
26. Fernandez-Botran, R., Chilton, P. M., Ma, Y., Windsor, J. L., Street, N. E. (1997) The production of soluble interleukin 4 receptors is preferentially regulated by the murine Th2 cell subset. Cytokine 9, 166-177.
27. + T cells. Annu. Rev. Immunol. 12, 635-673.
28. + T cell responses: The alternative approaches. Annu. Rev. Immunol. 15, 297-322.
29. Reiner, S. L., Locksley, R. M. (1995) The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13, 151-177.
30. Kuhn, R., Rajewsky, K., Müller, W. (1991) Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
31. Beckmann, M. P., Schooley, K. A., Gallis, B., Vandenbos, T., Friend, D., Alpert, A. R., Raunio, R., Prickett, K. S., Parker, P. E., Park, L. S. (1990) Monoclonal antibodies block murine IL-4-receptor function. J. Immunol. 144, 4212-4217.
32. Wysocka, M., Kubin, M., Vieira, L., Ozmen, L., Garotta, G., Scott, P., Trinchieri, G. (1995) Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25, 672-676.
33. Ohara, J., Paul, W. E. (1985) Production of a monoclonal antibody to and molecular characterization of B cell stimulatory factor-1. Nature 315, 333-336.
34. Leo, O., Foo, M., Sachs, D., Samelson, L., Bluestone, J. (1987) Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84, 1374-1378.
35. Spitalny, G., Havell, E. (1984) Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced anti-viral and macrophage tumoricidal activities. J. Exp. Med. 159, 1560-1565.
36. Cherwinski, H. M., Schumacher, J. H., Brown, K. D., Mosmann, T. R. (1987) Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166, 1229-1244.
37. Hondowicz, B. D., Scharton-Kersten, T. M., Jones, D. E., Scott, P. (1997) Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response. J. Immunol. 159, 5024-5031.
38. Detolla, L. J., Scott, P. A., Farrell, J. P. (1981) Single gene control of resistance to cutaneous leishmaniasis in mice. Immunogenet. 14, 29-39.
39. Mock, B., Blackwell, J., Hilgers, J., Potter, M., Nacy, C. (1983) Genetic control of Leishmania major infection in congenic, recombinant inbred and F2 populations of mice. Eur. J. Immunogenet. 20, 335-348.
40. Blackwell, J. M., Hale, C., Roberts, M. B., Ulczak, O. M., Liew, F. W., Howard, J. G. (1985) An H-11-linked gene has a parallel effect on L. major and L. donovani infections in mice. Immunogenet. 21, 385-395.
41. Locksley, R. M., Heinzel, F. P., Sadick, M. D., Holaday, B. J., Gardner, K. D. (1987) Murine cutaneous Leishmaniasis. Susceptibility correlates with differential expansion of helper T cell subsets. Ann. Inst. Pasteur/ Immunol. 138, 744-749.
42. Scott, P., Natovitz, P., Coffman, R. L., Pearce, E., Sher, A. (1988) Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168, 1675-1684.
43. Holaday, B. J., Sadick, M. D., Wang, Z.-E., Reiner, S. L., Heinzel, F. P., Parslow, T. G., Locksley, R. M. (1991) Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J. Immunol. 147, 1653-1658.
44. Morris, L., Troutt, A. B., Mcleod, K. S., Kelso, A., Handman, E., Aebischer, T. (1993) Interleukin 4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis. Infect. Immun. 61, 3459-3465.
45. Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G., Scott, P. (1994) The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263, 235-237.
46. Manetti, R., Parronchi, P., Giudizi, M. G., Piccini, M.-P., Maggi, E., Trinchieri, G., Romagnani, S. (1993) Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177, 1199-1204.
47. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E., Gately, M. K. (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177, 1505-1509.
48. Sypek, J. P., Chung, C. L., Major, S. E. H., Subramanyam, J. M., Goldman, S. J., Sieburth, D. S., Wolf, S. F., Schaub, R. G. (1993) Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective Th1 immune response. J. Exp. Med. 177, 1797-1802.
49. +) T cells. Eur. J. Immunol. 24, 343-347.
50. Scharton-Kesten, T., Afonso, L. C. C., Wysocka, M., Trinchieri, G., Scott, P. (1995) IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154, 5320-5330.
51. Heinzel, F. P., Rerko, R. M., Ahmed, F., Pearlman, E. (1995) Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice. J. Immunol. 155, 730-739.
52. Nabors, G. S., Afonso, L. C. C., Farrell, J. P., Scott, P. (1995) Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin-12 and pentostam. Proc. Natl. Acad. Sci. USA 92, 3142-3146.
53. Chilton, P. M., Fernandez-Botran, R. (1997) Regulation of the expression of the soluble and membrane forms of the murine IL-4 receptor. Cell. Immunol. 180, 104-115.
54. Pearce, E. J., Cheever, A., Leonard, S., Covalesky, M., Fernandez-Botran, R., Kohler, G., Kopf, M. (1996) Schistosomiasis mansoni in IL-4-deficient mice. Int. Immunol. 8, 435-444.
55. Blum, H., Wolf, M., Enssle, K., Rollinghoff, M., Gessner, A. (1996) Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. J. Immunol. 157, 1846-1853.