The Mechanism of in Vitro T Helper Cell Type 1 to T Helper Cell Type 2 Switching in Highly Polarized Leishmania major-Specific T Cell Populations

Journal of Immunology

Volumn 158, Issue 4, 1997, Pages 1559-1564

  Mocci, Simonetta ^a   Coffman, Robert L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INTERLEUKIN 4; L SELECTIN; PARASITE ANTIGEN;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL MOTION; CELL POLARITY; CYTOLOGY; FEMALE; IMMUNOLOGY; LEISHMANIA MAJOR; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; SKIN LEISHMANIASIS; STEM CELL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; THYMUS;

ANIMALS; ANTIGENS, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CELL POLARITY; CELLS, CULTURED; EPITOPES; FEMALE; INTERLEUKIN-4; L-SELECTIN; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; STEM CELLS; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS; THYMUS GLAND;

EID: 0031568540     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. + T-cell subsets: regulation of differentiation and function. Res. Immunol. 142:7.
2. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
3. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of Interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
4. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
5. Scott, P. 1991. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:3149.
6. Belosevic, M., D. S. Finbloom, P. H. Van Der Meide, M. V. Slayeter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
7. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T cell-dependent. Interferon γ-independent mechanism. J. Exp. Med. 171:115.
8. Sypek, J. P., C. L. Chung, S. E. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
9. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
10. Mocci, S., and R. L. Coffman. 1995. Induction of a Th2 population rom a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 154:3779.
11. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
12. Spenshaw, P., E. E. Murphy, N. A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182: 1357.
13. Gallantin, W. M., I. L. Weissman, and E. C. Butcher. 1983 A cell surface molecule involved in organ-specific homing of lymphocytes. Nature 304:30.
14. + memory T cells from the spleen lack MEL-14, the lymph node homing receptor. J. Immunol. 148:324.
15. + T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176:1431.
16. Mackay, C. R., W. L. Marston, and L. Dudler. 1990. Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 171:801.
17. + T cell populations that produce different cytokines. Eur. J. Immunol. 19: 617.
18. Dianzani, U., M. Luqman, J. Rojo, J. Yagi, J. Baron, A. Woods, C. A. J. Janeway, and K. Bottomly. 1990. Molecular associations on the T cell surface correlate with immunological memory. Eur. J. Immunol. 20:2249.
19. Budd, R. C. J.-C. Cerottini, C. Horvath, C. Bron, T. Pedrazzini, R. C. Howe, and H. R. MacDonald. 1987. Distinction of virgin and memory T lymphocytes: stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J. Immunol. 138:3120.
20. Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183:901.
21. + effector T cells in vivo: immunization results in a transient population of Mel-14-, CD45RB-helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4 and interferon-γ. J. Exp. Med. 174:547.
22. + T cell subsets: lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro. J. Immunol. 144:1788.
23. Maggi, E., P. Parronchi, R. Manetti, C. Simonelli, M. P. Piccinni, F. S. Rugiu, M. De Carli, M. Ricci, and S. Romagnani. 1992. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 148:2142.
24. + T cells, analyzed at the single-cell level. J. Exp. Med. 184:1.
25. Perez, V. L., J. A. Lederer, A. H. Lichtman, and A. K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869.
26. Swain, S. L. 1994. Generation and in vivo persistence of polarized ThI and Th2 memory cells. Immunity 1:543.
27. Croft, M., and S. L. Swain. 1995. Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J. Imnumol. 154:4269.
28. Tough, D. F., and J. Sprent. 1994. Turnover of naive-and memory-phenotype T cells. J. Exp. Med. 179:1127.
29. Hayden, K. A., D. F. Tough, and S. R. Webb. 1996. In vivo response of mature T cells to Misa antigens: long-term progeny of dividing cells include cells with a naive phenotype. J. Immunol. 156:48.
30. Mobley, J. L., S. M. Rigby, and M. O. Dailey. 1994. Regulation of adhesion molecule expression by CD8 T cells in vivo. II. Expression of L-selectin (CD62L) by memory cytolytic T cells responding to minor histocompatibility antigens. J. Immunol. 153:5443.
31. + memory T cells. J. Immunol. 154:5870.
32. Holaday, B. J., M. D. Sadick, Z. E. Wang, S. L. Reiner, F. P. Heinzel, T. G. Parslow, and R. M. Locksley. 1991. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1-and Th2-like cell lines. J. Immunol. 147:1653.