Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 7063-7070

  Spielman, Julie ^a   Lee, Richard K ^a   Podack, Eckhard R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; PERFORIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; IMMUNE RESPONSE; LIGAND BINDING; MACROPHAGE ACTIVATION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TARGET CELL; TISSUE INJURY;

ANIMALS; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASES; CARRAGEENAN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; ENDOMETRITIS; FAS LIGAND PROTEIN; FEEDBACK; FEMALE; INFERTILITY, FEMALE; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; PANCREAS; PANCREATITIS; PORE FORMING CYTOTOXIC PROTEINS; PREGNANCY; SALPINGITIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED; UTERUS;

EID: 0032534572     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Millard, P. J., M. P. Henkart, C. W. Reynolds, and P. A. Henkart. 1984. Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors. J. Immunol. 132:3197.
2. Podack, E. R., and P. J. Konigsberg. 1984. Cytolytic T cell granules: isolation, structural, biochemical, and functional characterization. J. Exp. Med. 160:695.
3. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195.
4. + cytotoxic T lymphocyte-mediated lysis. J. Immunol. 150:4303.
5. Ruddle, N. H., M. B. Powell, and B. S. Conta. 1983. Lymphotoxin, a biologically relevant model lymphokine. Lymphokine Res. 2:23.
6. Takahashi, T., M. Tanaka, C. I. Brannan, N. A. Jenkins, N. G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969.
7. Watanabe, F. R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in fas antigen that mediates apoptosis. Nature 356:314.
8. + cells and autoimmunity. J. Immunol. 153:5855.
9. Podack, E. R. 1995. Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways. Curr. Opin. Immunol. 7:11.
10. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
11. Lowin, B., F. Beermann, A. Schmidt, and J. Tschopp. 1994. A null mutation in the perform gene impairs cytolytic T lymphocyte-and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA 91:11571.
12. Walsh, C. M., M. Matloubian, C. C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. Huang, J. D. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA 91:10854.
13. Van den Broek, M. E., D. Kagi, F. Ossendorp, R. Toes, S. Vamvakas, W. K. Lutz, C. J. Melief, R. M. Zinkernagel, and H. Hengartner. 1996. Decreased tumor surveillance in perforin-deficient mice. J. Exp. Med. 184:1781.
14. Elkon, K. B., and A. Marshak-Rothstein. 1996. B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men. Curr: Opin. Immunol. 8:852.
15. Nagata, S. 1996. Apoptosis: telling cells their time is up. Curr. Biol. 6:1241.
16. Lenardo, M. J. 1996. Fas and the art of lymphocyte maintenance. J. Exp. Med. 183:721.
17. Depraetere, V., and P. Golstein. 1997. Fas and other cell death signaling pathways. Semin. Immunol. 9:93.
18. Bjorck, P., J. Banchereau, and L. Flores-Romo. 1997. CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells. Int. Immunol. 9:365.
19. + lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway. Proc. Natl. Acad. Sci. USA 92:11225.
20. Taniguchi, Y., M. R. Ito, S. Mori, S. Yonehara, and M. Nose. 1996. Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis. Clin. Exp. Immunol. 106:26.
21. + T lymphocyte clones. J. Immunol. 158:5612.
22. + T cells via Fas/Fas ligand-mediated apoptosis. J. Immunol. 158:1503.
23. + T cells. J. Immunol. 159:2091.
24. + T cells. J. Immunol. 148: 3354.
25. + human CTL clones induced by candidate AIDS vaccines. J. Immunol. 153:2787.
26. Barany, F. 1991. Genetic disease detection and DNA amplification using cloned thermostable ligase. Proc. Natl. Acad. Sci. USA 88:189.
27. Lee, R. K., J. Spielman, D. Y. Zhao, K. J. Olsen, and E. R. Podack. 1996. Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells. J. Immunol. 157:1919.
28. + T cells responding to a bacterial superantigen. J. Immunol. 154:4302.
29. Calderon, C., Z. H. Huang, D. A. Gage, E. M. Sotomayor, and D. M. Lopez. 1994. Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine. J. Exp. Med. 180:945.
30. Renno, T., M. Hahne, J. Tschopp, and H. R. MacDonald. 1996. Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and up-regulate Fas and Fas ligand. J. Exp. Med. 183:431.
31. Weintraub, J. P., R. A. Eisenberg, and P. L. Cohen. 1997. Up-regulation of Fas and the costimulatory molecules B7-1 and B7-2 on peripheral lymphocytes in autoimmune B6/gld mice. J. Immunol. 159:4117.
32. Peng, S. L., J. Moslehi, M. E. Robert, and J. Craft. 1998. Perforin protects against autoimmunity in lupus-prone mice. J. Immunol. 160:652.
33. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
34. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270:985.
35. Wiley, S. R., K. Schooley, P. S. Smolak, W. S. Din, C. P. Huang, J. K. Nicholl, G. R. Sutherland, T. D. Smith, C. Rauch, C. A. Smith et al. 1995. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673.
36. Walczak, H., M. A. Degli-Esposti, R. S. Johnson, P. J. Smolak, J. Y. Waugh, N. Boiani, M. S. Timour, M. J. Gerhart, K. A. Schooley, C. A. Smith, R. G. Goodwin, and C. T. Rauch. 1997. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16:5386.
37. Schneider, P., M. Thome, K. Burns, J. L. Bodmer, K. Hofmann, T. Kataoka, N. Holler, and J. Tschopp. 1997. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity 7:831.
38. Chaudhary, P. M., M. Eby, A. Jasmin, A. Bookwalter, J. Murray, and L. Hood. 1997. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway. Immunity 7:821.
39. Degli-Esposti, M. A., P. J. Smolak, H. Walczak, J. Waugh, C. P. Huang, R. F. DuBose, R. G. Goodwin, and C. A. Smith. 1997. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J. Exp. Med. 186:1165.
40. MacFarlane, M., M. Ahmad, S. M. Srinivasula, T. Fernandes-Alnemri, G. M. Cohen, and E. S. Alnemri. 1997. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 272:25417.
41. Marsters, S. A., J. P. Sheridan, R. M. Pitti, J. Brush, A. Goddard, and A. Ashkenazi. 1998. Identification of a ligand for the death-domain-containing receptor Apo3. Curr. Biol. 8:525.
42. Chicheportiche, Y., P. R. Bourdon, H. Xu, Y. M. Hsu, H. Scott, C. Hession, I. Garcia, and J. L. Browning. 1997. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 272:32401.
43. Kitson, J., T. Raven, Y. P. Jiang, D. V. Goeddel, K. M. Giles, K. T. Pun, C. J. Grinham, R. Brown, and S. N. Farrow. 1996. A death-domain-containing receptor that mediates apoptosis. Nature 384:372.
44. Bodmer, J. L., K. Burns, P. Schneider, K. Hofmann, V. Steiner, M. Thome, T. Bornand, M. Hahne, M. Schroter, K. Becker, A. Wilson, L. E. French, J. L. Browning, H. R. MacDonald, and J. Tschopp. 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity 6:79.
45. Chinnaiyan, A. M., K. O'Rourke, G. L. Yu, R. H. Lyons, M. Garg, D. R. Duan, L. Xing, R. Gentz, J. Ni, and V. M. Dixit. 1996. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274: 990.
46. Braun, M. Y., B. Lowin, L. French, H. Acha-Orbea, and J. Tschopp. 1996. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J. Exp. Med. 183:657.