The taxonomy of developmental control in Caenorhabditis elegans

Science

Volumn 282, Issue 5396, 1998, Pages 2033-2041

  Ruvkun, Gary ^a   Hobert, Oliver ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CAENORHABDITIS ELEGANS; CELL DEATH; DEVELOPMENT; DROSOPHILA; GENE CONTROL; GENE FUNCTION; GENE MAPPING; GENETIC CONSERVATION; HOMEOBOX; HUMAN; MULTIGENE FAMILY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TAXONOMY; TRANSCRIPTION TERMINATION;

ANIMALS; CAENORHABDITIS ELEGANS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HELMINTH; GENES, HOMEOBOX; GENOME; HELMINTH PROTEINS; MULTIGENE FAMILY; PHYLOGENY; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS; INVERTEBRATA; METAZOA; VERTEBRATA;

EID: 0032509303     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5396.2033     Document Type: Review

References (3)

1. W. B. Wood, Ed., The Nematode C. elegans (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1988); D. L. Riddle et al., Eds., C. elegans II (Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, 1997).
2. W. B. Wood, Ed., The Nematode C. elegans (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1988); D. L. Riddle et al., Eds., C. elegans II (Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, 1997).
3. We classify gene superfamilies mainly based on phylogenetic analyses that are presented on the Web page www.sciencemag.org/feature/data/985556.shl. Routinely, searches were first performed using BLASTP on the Wormpep dataset posted on the C. elegans genome blast server www.sanger.ac.uk/projects/c_etegans/blast_ server.shtml (which at the time of this analysis was Wormpep 15 plus a number of unannotated sequences now included in Wormpep 16) and afterward confirmed using TBLASTN on the genomic sequence dataset on the C. elegans blast server. The probable ortholog of a C. elegans gene is the most closely related vertebrate or other invertebrate protein that by BLAST and/or dendrogram analysis (using the neighborjoining method on a distance matrix created with the Kimura protein distance algorithm) is significantly more closely related than the next most closely related member of the gene superfamily. General information about the datasets and annotations can be found at: http://www.sciencemag.org/feature/data/c-elegans.shl.