Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport

Journal of Lipid Research

Volumn 37, Issue 7, 1996, Pages 1556-1568

  Underwood, Kathryn W ^a   Andemariam, Biree ^a   McWilliams, Gail L ^a   Liscum, Laura ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cholesterol; hydrophobic amine; imipramine; low density lipoprotein; transport; U18666A

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; AMINE; CHOLESTEROL; GLYCOPROTEIN P; IMIPRAMINE; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL MEMBRANE; CHO CELL; CHOLESTEROL ESTERIFICATION; CHOLESTEROL TRANSPORT; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HYDROPHOBICITY; LIGAND BINDING; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANDROSTENES; ANIMALS; ANTICHOLESTEREMIC AGENTS; BINDING SITES; BIOLOGICAL TRANSPORT; CHO CELLS; CHOLESTEROL; CHOLESTEROL OXIDASE; CRICETINAE; ENDOPLASMIC RETICULUM; ESTERIFICATION; IMIPRAMINE; INTRACELLULAR MEMBRANES; LIPOPROTEINS, LDL; LIVER; LYSOSOMES; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 0029996993     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Lange, Y. 1991. Disposition of intracellular cholesterol in human fibroblasts. J. Lipid Res. 32: 329-339.
2. Warnock, D. E., C. Roberts, M. S. Lutz, W. A. Blackburn, W. W. Young, and J. U. Baenziger. 1993. Determination of plasma membrane lipid mass and composition in cultured Chinese hamster ovary cells using high gradient magnetic affinity chromatography. J. Biol. Chem. 268: 10145-10153.
3. DeGrella, R. F., and R. D. Simoni. 1982. Intracellular transport of cholesterol to the plasma membrane. J. Biol. Chem. 257: 14256-14262.
4. Lange, Y., F. Echevarria, and T. Steck. 1991. Movement of zymosterol, a precursor of cholesterol, among three membranes in human fibroblasts. J. Biol. Chem. 266: 21439-21443.
5. Johnson, W. J., G. K. Chacko, M. C. Philips, and G. H. Rothblat. 1990. The efflux of lysosomal cholesterol from cells. J. Biol. Chem. 265: 5546-5553.
6. Xu, X-X., and I. Tabas. 1991. Lipoproteins activate acylcoenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level. J. Biol. Chem. 266: 17040-17048.
7. Reinhart, M. P. 1990. Intracellular sterol trafficking. Experientia. 46: 599-611.
8. Pentchev, P. G., M. E. Comly, H. S. Kruth, M. T. Vanier, D. A. Wenger, S. Patel, and R. O. Brady. 1985. A defect in cholesterol esterification in Niemann-Pick disease (type C) patients. Proc. Natl. Acad. Sci. USA. 82: 8247-8251.
9. Liscum, L., and J. R. Faust. 1987. Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts. J. Biol. Chem. 262: 17002-17008.
10. Pentchev, P. G., M. E. Comly, H. S. Kruth, T. Tokoro, J. Butler, J. Sokol, M. Filling-Katz, J. M. Quirk, D. C. Marshall, S. Patel, M. T. Vanier, and R. O. Brady. 1987. Group C Niemann-Pick disease: faulty regulation of low-density lipoprotein uptake and cholesterol storage in cultured fibroblasts. FASEB J. 1: 40-45.
11. Liscum, L., R. M. Ruggiero, and J. R. Faust. 1989. The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick Type C fibroblasts. J. Cell Biol. 108: 1625-1636.
12. Cadigan, K. M., D. M. Spillane, and T-Y. Chang. 1990. Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking. J. Cell Biol. 110: 295-308.
13. Dahl, N. K., K. L. Reed, M. A. Daunais, J. R. Faust, and L. Liscum. 1992. Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of LDL-derived cholesterol. J. Biol. Chem. 267: 4889-4896.
14. Dahl, N. K., M. A. Daunais, and L. Liscum. 1994. A second complementation class of cholesterol transport mutants with a variant Niemann-Pick type C phenotype. J. Lipid Res. 35: 1839-1849.
15. Panini, S. R., R. C. Sexton, and H. Rudney. 1984. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis. Possible mediators of low density lipoprotein action. J. Biol. Chem. 259: 7767-7771.
16. Liscum, L., and J. R. Faust. 1989. The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J. Biol. Chem. 264: 11796-11806.
17. Harmala, A-S., M. I. Porn, P. Mattjus, and J. P. Slotte. 1994. Cholesterol transport from plasma membranes to intracellular membranes is inhibited by 3β-[2-(diethylamino)ethoxy]androst-5-en-17-one. Biochim. Biophys. Acta. 1211: 317-325.
18. Rodriguez-Lafrasse, C., R. Rousson, J. Bonnet, P. G. Pentchev, P. Louisot, and M. T. Vanier. 1990. Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease. Biochim. Biophys. Acta. 1043: 123-128.
19. Lange, Y. 1994. Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. J. Biol. Chem. 269: 3411-3414.
20. Field, F. J., E. Born, H. Chen, S. Murthy, and S. N. Mathur. 1995. Esterification of plasma membrane cholesterol and triacylglycerol-rich lipoprotein secretion in CaCo-2 cells: possible role of p-glycoprotein. J. Lipid Res. 36: 1533-1543.
21. Goldstein, J. L., S. K. Basu, and M. S. Brown. 1983. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98: 241-260.
22. Faust, J. R., J. L. Goldstein, and M. S. Brown. 1977. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells. J. Biol. Chem. 252: 4861-4871.
23. Slotte, J. P., G. Hedstrom, S. Rannstrom, and S. Ekman. 1989. Effects of sphingomyelin degradation on cell cholesterol oxidizability and steady-state distribution between the cell surface and the cell interior. Biochim. Biophys. Acta. 985: 90-96.
24. Slotte, J. P., and E. L. Bierman. 1988. Depletion of plasma membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts. Biochem. J. 250: 653-658.
25. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
26. Lange, Y., and B. V. Ramos. 1983. Analysis of the distribution of cholesterol in the intact cell. J. Biol. Chem. 258: 15130-15134.
27. Roff, C. F., E. Goldin, M. E. Comly, A. Cooney, A. Brown, M. T. Vanier, S. P. F. Miller, R. O. Brady, and P. G. Pentchev. 1991. Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport. Dev. Neurosci. 13: 315-320.
28. Fujiki, Y., A. L. Hubbard, S. Fowler, and P. B. Lazarow. 1982. Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum. J. Cell Biol. 93: 97-102.
29. Liscum, L. 1990. Pharmacological inhibition of the intracellular transport of low-density lipoprotein-derived cholesterol in Chinese hamster ovary cells. Biochim. Biophys. Acta. 1045: 40-48.
30. Liscum, L., and G. J. Collins. 1991. Characterization of Chinese hamster ovary cells that are resistant to 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibition of low density lipoprotein-derived cholesterol metabolism. J. Biol. Chem. 266: 16599-16606.
31. Butler, J. D., J. Blanchette-Mackie, E. Goldin, R. R. O'Neill, G. Carstea, C. F. Roff, M. C. Patterson, S. Patel, M. E. Comly, A. Cooney, M. T. Vanier, R. O. Brady, and P. G. Pentchev. 1992. Progesterone blocks cholesterol translocation from lysosomes. J. Biol. Chem. 267: 23797-23805.
32. Lange, Y., and T. L. Steck. 1994. Cholesterolhomeostasis. Modulation by amphiphiles. J. Biol. Chem. 269: 29371-29374.
33. Schissel, S. L., N. Beatini, X. Zha, F. R. Maxfield, and I. Tabas. 1995. Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells. Biochemistry. 34: 10463-10473.
34. s values for cytochrome P450 and other membrane bound receptors and enzymes. FEBS Lett. 67: 123-129.
35. Porn, M. I., and J. P. Slotte. 1995. Localization of cholesterol in sphingomyelinase-treated fibroblasts. Biochem. J. 308: 269-274.