Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation

Current Opinion in Lipidology

Volumn 9, Issue 2, 1998, Pages 137-140

  Osborne, Timothy F ^a   Rosenfeld, John M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL SURFACE RECEPTOR; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEMBRANE PROTEIN; REGULATOR PROTEIN; STEROL;

CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; METABOLIC REGULATION; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SHORT SURVEY; SIGNAL TRANSDUCTION;

CARRIER PROTEINS; CELL MEMBRANE; CELLS, CULTURED; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUTATION; NIEMANN-PICK DISEASES; PROTEINS; RECEPTORS, LDL; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 0031899024     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199804000-00010     Document Type: Short Survey

References (15)

1. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232:34-47.
2. Chin DJ, Gil G, Russell DW, Liscum L, Luskey KL, Basu SK, et al. Nucleotide sequence of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. Nature 1984; 308:613-617.
3. Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell 1985; 41:249-258.
4. Roitelman J, Olender EH, Bar-Nun S, Dun WAJ, Simoni RD. Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum J Biol Chem 1992; 117:959-973.
5. Kumagi H, Chun KT, Simoni RD. Molecular dissection of the role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Biol Chem 1995; 270:19107-19113.
6. Hua X, Nohturfft A, Goldstein JL, Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 1996; 87:415-426.
7. Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C. et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 1997; 277:228-231.
8. Nohturfft A, Hua X, Brown MS, Goldstein JL. Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proc Natl Acad Sci USA 1996; 93:13709-13714.
9. Sakai J, Nohturtf A, Cheng D, Ho YK, B MS, Goldstein JL. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. J Biol Chem 1997; 272:20213-20221.
10. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997; 89:331-340.
11. Osborne TF. Cholesterol homeostasis: Clipping out a slippery regulator. Curr Biol 1997: 7 (Suppl):R172-R174.
12. Porter JA, Young KE, Beachy PA. Cholesterol modification of hedgehog signaling proteins in animal development. Science 1996; 274:255-259.
13. Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ, Biochemical evidence that patched is the hedgehog receptor. Nature 1996; 384:176-179.
14. Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL. et al. The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehog. Nature 1996; 384:129-134.
15. Porter JA, Ekker SC, Park W-J, von Kessler DP, Young KE, Chen CH, et al. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 1996; 86:21-34.