메뉴 건너뛰기




Volumn 10, Issue 2, 2000, Pages 249-259

Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P53;

EID: 0034079777     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2000.tb00258.x     Document Type: Article
Times cited : (145)

References (54)
  • 1
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • Baswlga J, Norton L, Albanell J, Kim YM, Mendelsohn J (1998) Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 58: 2825-2831
    • (1998) Cancer Res , vol.58 , pp. 2825-2831
    • Baswlga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.M.4    Mendelsohn, J.5
  • 2
    • 0030778862 scopus 로고    scopus 로고
    • Amplification and overexpression of MDM2 in primary (de novo) glioblastomas
    • Biernat W, Kleihues P, Yonekawa Y, Ohgaki H (1997) Amplification and overexpression of MDM2 in primary (de novo) glioblastomas. J Neuropathol Exp Neurol 56: 180-185
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 180-185
    • Biernat, W.1    Kleihues, P.2    Yonekawa, Y.3    Ohgaki, H.4
  • 3
    • 0030881477 scopus 로고    scopus 로고
    • Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas
    • Biernat W, Tohma Y, Yonekawa Y, Kleihues P, Ohgaki H (1997) Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol 94: 303-309
    • (1997) Acta Neuropathol , vol.94 , pp. 303-309
    • Biernat, W.1    Tohma, Y.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 5
    • 0031906358 scopus 로고    scopus 로고
    • Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas
    • Burns KL, Ueki K, Jhung SL, Koh J, Louis DN (1998) Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas. J Neuropathol Exp Neurol 57: 122-130
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 122-130
    • Burns, K.L.1    Ueki, K.2    Jhung, S.L.3    Koh, J.4    Louis, D.N.5
  • 11
    • 0026517069 scopus 로고
    • p53 mutations in human malignant gliomas: Comparison of loss of heterozygosity with mutation frequency
    • Frankel RH, Bayona W, Koslow M, Newcomb EW (1992) p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. Cancer Res 52: 1427-1433
    • (1992) Cancer Res , vol.52 , pp. 1427-1433
    • Frankel, R.H.1    Bayona, W.2    Koslow, M.3    Newcomb, E.W.4
  • 12
    • 0032893878 scopus 로고    scopus 로고
    • Regulation of the p53 protein by the MDM2 oncoprotein-thirty-eighth G.H.A. Clowes memorial award lecture
    • Freedman D, Levine AJ (1999) Regulation of the p53 protein by the MDM2 oncoprotein-Thirty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 59: 1-7
    • (1999) Cancer Res , vol.59 , pp. 1-7
    • Freedman, D.1    Levine, A.J.2
  • 13
    • 0026547577 scopus 로고
    • p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression
    • Fults D, Brockmeyer D, Tullous MW, Pedone CA, Cawthon RM (1992) p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Res 52: 674-679
    • (1992) Cancer Res , vol.52 , pp. 674-679
    • Fults, D.1    Brockmeyer, D.2    Tullous, M.W.3    Pedone, C.A.4    Cawthon, R.M.5
  • 14
    • 0031740916 scopus 로고    scopus 로고
    • Alterations of the p16-Rb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: Relationship with p53 and MDM2 protein expression
    • Gorgoulis VG, Zacharatos P, Kotsinas A, Liloglou T, Kyroudi A, Veslemes M, Rassidakis A, Halazonetis, Field JK, Kittas C (1998) Alterations of the p16-Rb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: Relationship with p53 and MDM2 protein expression. Am J Pathol 153: 1749-1765
    • (1998) Am J Pathol , vol.153 , pp. 1749-1765
    • Gorgoulis, V.G.1    Zacharatos, P.2    Kotsinas, A.3    Liloglou, T.4    Kyroudi, A.5    Veslemes, M.6    Rassidakis, A.7    Field, J.K.8    Kittas, C.9
  • 15
    • 0030797470 scopus 로고    scopus 로고
    • Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme
    • Hayashi Y, Ueki K, Waha A, Wiestler OD, Louis DN, von Deimling A (1997) Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol 7: 871-875
    • (1997) Brain Pathol , vol.7 , pp. 871-875
    • Hayashi, Y.1    Ueki, K.2    Waha, A.3    Wiestler, O.D.4    Louis, D.N.5    Von Deimling, A.6
  • 18
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA, Bradley A (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 22
    • 0028087884 scopus 로고
    • Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors
    • Lang FF, Miller DC, Koslow M, Newcomb EW (1994) Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 81: 427-436
    • (1994) J Neurosurg , vol.81 , pp. 427-436
    • Lang, F.F.1    Miller, D.C.2    Koslow, M.3    Newcomb, E.W.4
  • 23
    • 0028107586 scopus 로고
    • High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas
    • Lang FF, Miller DC, Pisharody S, Koslow M, Newcomb, EW (1994) High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. Oncogene 9: 949-954
    • (1994) Oncogene , vol.9 , pp. 949-954
    • Lang, F.F.1    Miller, D.C.2    Pisharody, S.3    Koslow, M.4    Newcomb, E.W.5
  • 24
    • 0028240974 scopus 로고
    • The lack of a role for p53 in astocytomas in pediatric patients
    • Litofsky NS, Hinton D, Raffel C (1994) The lack of a role for p53 in astocytomas in pediatric patients. Neurosurgery 34: 967-973
    • (1994) Neurosurgery , vol.34 , pp. 967-973
    • Litofsky, N.S.1    Hinton, D.2    Raffel, C.3
  • 25
    • 0027261003 scopus 로고
    • Molecular genetics of pediatric brain stem gliomas. Application of pcr techniques to small and archival brain tumor specimens
    • Louis DN, Rubio M-P, Correa KM, Gusella JF, von Deimling A (1993) Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens. J Neuropathol Exp Neurol 52: 507-515
    • (1993) J Neuropathol Exp Neurol , vol.52 , pp. 507-515
    • Louis, D.N.1    Rubio, M.-P.2    Correa, K.M.3    Gusella, J.F.4    Von Deimling, A.5
  • 27
    • 0030946460 scopus 로고    scopus 로고
    • A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors
    • Moscatello DK, Ramirez G, Wong AJ (1997) A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors. Cancer Res 57: 1419-1424
    • (1997) Cancer Res , vol.57 , pp. 1419-1424
    • Moscatello, D.K.1    Ramirez, G.2    Wong, A.J.3
  • 28
    • 0031679407 scopus 로고    scopus 로고
    • Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes
    • Newcomb EW, Cohen C, Lee SR, Bhalla SK, Bloom J, Hayes RL, Miller DC (1998) Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. Brain Pathol 8: 655-667
    • (1998) Brain Pathol , vol.8 , pp. 655-667
    • Newcomb, E.W.1    Cohen, C.2    Lee, S.R.3    Bhalla, S.K.4    Bloom, J.5    Hayes, R.L.6    Miller, D.C.7
  • 29
    • 0027313366 scopus 로고
    • A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme
    • Newcomb EW, Madonia WJ, Pisharody S, Lang FF, Koslow M, Miller DC (1993) A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme. Brain Pathol 3: 229-235
    • (1993) Brain Pathol , vol.3 , pp. 229-235
    • Newcomb, E.W.1    Madonia, W.J.2    Pisharody, S.3    Lang, F.F.4    Koslow, M.5    Miller, D.C.6
  • 31
    • 0033118889 scopus 로고    scopus 로고
    • Inhibitory effects of combinations of HER-1/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
    • Pegram M, Hsu S, Lewis G, Pietras R, Beryt M, Sliwkowski M, Coombs D, Baly D, Kabbinavar F, Slamon D (1999) Inhibitory effects of combinations of HER-1/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18: 2241-2251
    • (1999) Oncogene , vol.18 , pp. 2241-2251
    • Pegram, M.1    Hsu, S.2    Lewis, G.3    Pietras, R.4    Beryt, M.5    Sliwkowski, M.6    Coombs, D.7    Baly, D.8    Kabbinavar, F.9    Slamon, D.10
  • 34
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle DE, Zindy F, Ashmun RA, Sherr CJ (1995) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993-1000
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 36
    • 0030909375 scopus 로고    scopus 로고
    • A correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4 genes in astrocytomas
    • Rao LS, Miller DC, Newcomb EW (1997) A correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4 genes in astrocytomas. Diag Mol Pathol 6: 15-122
    • (1997) Diag Mol Pathol , vol.6 , pp. 15-122
    • Rao, L.S.1    Miller, D.C.2    Newcomb, E.W.3
  • 38
    • 0027196974 scopus 로고
    • Amplification and overexpression of MDM2 gene in a subset of human ma ignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP (1993) Amplification and overexpression of MDM2 gene in a subset of human ma ignant gliomas without p53 mutations. Cancer Res 53: 2736-2739
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 40
    • 0030890851 scopus 로고    scopus 로고
    • A rapid and nonisotopic method for screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors
    • Soong R, lacopetta BJ (1997) A rapid and nonisotopic method for screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors. Mod Pathol 10: 252-258
    • (1997) Mod Pathol , vol.10 , pp. 252-258
    • Soong, R.1    Lacopetta, B.J.2
  • 45
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN (1996) CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56: 150-153
    • (1996) Cancer Res , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3    Efird, J.T.4    Von Deimling, A.5    Louis, D.N.6
  • 49
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
    • Watanabe K, Tachibana O, Sato K, Yonekawa Y, Kleihues P, Ohgaki H (1997) Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 6: 217-224
    • (1997) Brain Pathol , vol.6 , pp. 217-224
    • Watanabe, K.1    Tachibana, O.2    Sato, K.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 51
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang X-D, Jia X-C, Corvalan RF, Wang P, Davis CG, Jakobovits A (1999) Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res 59: 1236-1243
    • (1999) Cancer Res , vol.59 , pp. 1236-1243
    • Yang, X.-D.1    Jia, X.-C.2    Corvalan, R.F.3    Wang, P.4    Davis, C.G.5    Jakobovits, A.6
  • 52
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92: 725-734
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 54
    • 0004232308 scopus 로고
    • Prentice-Hall, Inc., Englewood Cliffs, NJ
    • Zar, JH (1984) Biostatistical Analysis. Prentice-Hall, Inc., Englewood Cliffs, NJ
    • (1984) Biostatistical Analysis
    • Zar, J.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.