메뉴 건너뛰기




Volumn 56, Issue 2, 1997, Pages 180-185

Amplification and overexpression of MDM2 in primary (de novo) glioblastomas

Author keywords

Amplification; MDM2; Overexpression; Primary glioblastoma; Secondary glioblastoma

Indexed keywords

PROTEIN P53;

EID: 0030778862     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199702000-00009     Document Type: Article
Times cited : (159)

References (40)
  • 2
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
    • Watanabe K, Tachibana O, Sato K, Yonekawa Y, Kleihues P, Ohgaki H. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996;6:217-24
    • (1996) Brain Pathol , vol.6 , pp. 217-224
    • Watanabe, K.1    Tachibana, O.2    Sato, K.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 3
    • 0028882666 scopus 로고
    • Genetic alterations associated with the evolution and progression of astrocytic brain tumours
    • Ohgaki H, Schauble B, zur Hausen A, von Ammon K, Kleihues P. Genetic alterations associated with the evolution and progression of astrocytic brain tumours. Virchows Arch 1995;427:113-18
    • (1995) Virchows Arch , vol.427 , pp. 113-118
    • Ohgaki, H.1    Schauble, B.2    Zur Hausen, A.3    Von Ammon, K.4    Kleihues, P.5
  • 4
    • 0026772431 scopus 로고
    • Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
    • Hermanson M, Funa K, Hartman M, et al. Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res 1992;52:3213-19
    • (1992) Cancer Res , vol.52 , pp. 3213-3219
    • Hermanson, M.1    Funa, K.2    Hartman, M.3
  • 5
    • 9044248587 scopus 로고    scopus 로고
    • Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas
    • Hermanson M, Funa K, Koopmann J, et al. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas. Cancer Res 1996;56:164-71
    • (1996) Cancer Res , vol.56 , pp. 164-171
    • Hermanson, M.1    Funa, K.2    Koopmann, J.3
  • 6
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 1996;56:150-53
    • (1996) Cancer Res , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3    Efird, J.T.4    Von Deimling, A.5    Louis, D.N.6
  • 8
    • 0028087884 scopus 로고
    • Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors
    • Lang FF, Miller DC, Koslow M, Newcomb EW Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg 1994;81:427-36
    • (1994) J Neurosurg , vol.81 , pp. 427-436
    • Lang, F.F.1    Miller, D.C.2    Koslow, M.3    Newcomb, E.W.4
  • 9
    • 0029094065 scopus 로고
    • A tiger behind many doors: Multiple genetic pathways to maligant glioma
    • Louis DN, Gusella JF. A tiger behind many doors: Multiple genetic pathways to maligant glioma. TIG 1995;11:412-15
    • (1995) TIG , vol.11 , pp. 412-415
    • Louis, D.N.1    Gusella, J.F.2
  • 10
  • 11
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 12
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993;53:2736-39
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 13
    • 0027978368 scopus 로고
    • Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2
    • Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins VP. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res 1994;54:4299-4303
    • (1994) Cancer Res , vol.54 , pp. 4299-4303
    • Reifenberger, G.1    Reifenberger, J.2    Ichimura, K.3    Meltzer, P.S.4    Collins, V.P.5
  • 14
    • 0026580876 scopus 로고
    • Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene
    • Brustle O, Ohgaki H, Schmitt HP, Walter GF, Ostertag H, Kleihues P. Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene. Cancer 1992;69:2385-92
    • (1992) Cancer , vol.69 , pp. 2385-2392
    • Brustle, O.1    Ohgaki, H.2    Schmitt, H.P.3    Walter, G.F.4    Ostertag, H.5    Kleihues, P.6
  • 15
    • 0028832159 scopus 로고
    • Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue
    • Hunter SB, Abbott K, Varma VA, Olson JJ, Barnett DW, James CD. Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue. J Neuropathol Exp Neurol 1995;54:57-64
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 57-64
    • Hunter, S.B.1    Abbott, K.2    Varma, V.A.3    Olson, J.J.4    Barnett, D.W.5    James, C.D.6
  • 16
    • 0027285132 scopus 로고
    • The p53 tumor suppressor protein: Meeting review
    • Prives C, Manfredi JJ. The p53 tumor suppressor protein: Meeting review. Genes Dev 1993;7:529-34
    • (1993) Genes Dev , vol.7 , pp. 529-534
    • Prives, C.1    Manfredi, J.J.2
  • 18
    • 0028899283 scopus 로고
    • Biochemical properties and biological effects of p53
    • Haffner R, Oren M. Biochemical properties and biological effects of p53. Curr Opin Genet Dev 1995;5:84-90
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 84-90
    • Haffner, R.1    Oren, M.2
  • 21
    • 0027244853 scopus 로고
    • The p53-MDM-2 autoregulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-MDM-2 autoregulatory feedback loop. Genes Dev 1993;7:1126-32
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 22
    • 0028049474 scopus 로고
    • Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
    • Barak Y, Gottlieb E, Juven Gershon T, Oren M. Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential. Genes Dev 1994;8:1739-49
    • (1994) Genes Dev , vol.8 , pp. 1739-1749
    • Barak, Y.1    Gottlieb, E.2    Juven Gershon, T.3    Oren, M.4
  • 23
    • 0027501841 scopus 로고
    • Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
    • Juven T, Barak Y, Zauberman A, George DL, Oren M. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 1993;8:3411-16
    • (1993) Oncogene , vol.8 , pp. 3411-3416
    • Juven, T.1    Barak, Y.2    Zauberman, A.3    George, D.L.4    Oren, M.5
  • 24
    • 0029131447 scopus 로고
    • A functional p53-responsive intronic promoter is contained within the human mdm2 gene
    • Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res 1995;23:2584-92
    • (1995) Nucleic Acids Res , vol.23 , pp. 2584-2592
    • Zauberman, A.1    Flusberg, D.2    Haupt, Y.3    Barak, Y.4    Oren, M.5
  • 25
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J 1993;12:461-68
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 26
    • 0026523614 scopus 로고
    • Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest
    • Barak Y, Oren M. Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J 1992;11:2115-21
    • (1992) EMBO J , vol.11 , pp. 2115-2121
    • Barak, Y.1    Oren, M.2
  • 27
    • 0027673764 scopus 로고
    • The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
    • Picksley SM, Lane DP. The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53? Bioessays 1993;15:689-90
    • (1993) Bioessays , vol.15 , pp. 689-690
    • Picksley, S.M.1    Lane, D.P.2
  • 28
    • 0027179604 scopus 로고
    • Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
    • Olson DC, Marechal V, Momand J, Chen J, Romocki C, Levine AJ. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene 1993;8:2353-60
    • (1993) Oncogene , vol.8 , pp. 2353-2360
    • Olson, D.C.1    Marechal, V.2    Momand, J.3    Chen, J.4    Romocki, C.5    Levine, A.J.6
  • 29
    • 0027232042 scopus 로고
    • p53 Mutation and MDM2 amplification in human soft tissue sarcomas
    • Leach FS, Tokino T, Meltzer P, et al. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993;53:2231-34
    • (1993) Cancer Res , vol.53 , pp. 2231-2234
    • Leach, F.S.1    Tokino, T.2    Meltzer, P.3
  • 30
    • 0028841834 scopus 로고    scopus 로고
    • MDM2 gene amplification in bone and soft-tissue tumors: Association with tumor progression in differentiated adiposetissue tumors
    • Nakayama T, Toguchida J, Wadayama B, Kanoe H, Kotoura Y, Sasaki MS. MDM2 gene amplification in bone and soft-tissue tumors: Association with tumor progression in differentiated adiposetissue tumors. Int J Cancer 1996;64:342-46
    • (1996) Int J Cancer , vol.64 , pp. 342-346
    • Nakayama, T.1    Toguchida, J.2    Wadayama, B.3    Kanoe, H.4    Kotoura, Y.5    Sasaki, M.S.6
  • 31
    • 0028098165 scopus 로고
    • Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
    • Cordon Cardo C, Latres E, Drobnjak M, et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994;54:794-99
    • (1994) Cancer Res , vol.54 , pp. 794-799
    • Cordon Cardo, C.1    Latres, E.2    Drobnjak, M.3
  • 33
    • 0028983308 scopus 로고
    • mdm2 gene alterations and mdm2 protein expression in breast carcinomas
    • Marchetti A, Buttitta F, Girlando S, et al. mdm2 gene alterations and mdm2 protein expression in breast carcinomas. J Pathol 1995;175:31-38
    • (1995) J Pathol , vol.175 , pp. 31-38
    • Marchetti, A.1    Buttitta, F.2    Girlando, S.3
  • 34
    • 0029020147 scopus 로고
    • Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
    • McCann AH, Kirley A, Carney DN, et al. Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br J Cancer 1995;71:981-85
    • (1995) Br J Cancer , vol.71 , pp. 981-985
    • McCann, A.H.1    Kirley, A.2    Carney, D.N.3
  • 35
    • 0028129547 scopus 로고
    • Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification
    • Habuchi T, Kinoshita H, Yamada H, et al. Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification. J Natl Cancer Inst 1994;86:1331-35
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1331-1335
    • Habuchi, T.1    Kinoshita, H.2    Yamada, H.3
  • 36
    • 0028023524 scopus 로고
    • Altered patterns of MDM2 and TP53 expression in human bladder cancer
    • Lianes P, Orlow I, Zhang ZF, et al. Altered patterns of MDM2 and TP53 expression in human bladder cancer. J Natl Cancer Inst 1994;86:1325-30
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1325-1330
    • Lianes, P.1    Orlow, I.2    Zhang, Z.F.3
  • 37
    • 0029054396 scopus 로고
    • mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations
    • Marchetti A, Buttitta F, Pellegrini S, et al. mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol 1995;4:93-97
    • (1995) Diagn Mol Pathol , vol.4 , pp. 93-97
    • Marchetti, A.1    Buttitta, F.2    Pellegrini, S.3
  • 38
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
    • Landers JE, Haines DS, Strauss JF, George DL. Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 1994;9:2745-50
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Strauss, J.F.3    George, D.L.4
  • 39
    • 0029028354 scopus 로고
    • Interaction between the retinoblastoma protein and the oncoprotein MDM2
    • Xiao ZX, Chen J, Levine AJ, et al. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 1995;375:694-98
    • (1995) Nature , vol.375 , pp. 694-698
    • Xiao, Z.X.1    Chen, J.2    Levine, A.J.3
  • 40
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 1996;15:1596-1606
    • (1996) EMBO J , vol.15 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.