The impact of genomics on novel antibacterial targets

Current Opinion in Drug Discovery and Development

Volumn 3, Issue 2, 2000, Pages 177-190

  Payne, David J ^a   Wallis, Nicola G ^a   Gentry, Daniel R ^a   Rosenberg, Martin ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antibacterial; Antibiotic; Biosynthesis; Fatty acid; Genomics; Peptidoglycan; tRNA synthetase; Two component signal transduction systems

Indexed keywords

2 AMINOCYCLOPENTANECARBOXYLIC ACID; AMINO ACID TRANSFER RNA LIGASE; ANTIINFECTIVE AGENT; BORRELIDIN; FURAN DERIVATIVE; GRANATICIN; INDOLE DERIVATIVE; OCHRATOXIN; PSEUDOMONIC ACID;

ANTIMICROBIAL ACTIVITY; BIOSYNTHESIS; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENOME; MICROORGANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033998632     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (86)

1. Martinis SA, Schimmel PAminoacyl tRNA synthetases: General features and relationships. In: Escherichia coli and Salmonella Molecular and Cell Biology (2nd Ed). Neidhardt FC, Curtiss R, Ingraham JL, Lin EC, Low KB, Magasanik B, Reznikoff W, Riley M, Shaechter M, Umbarger AE (Eds), ASM Press, Washington DC, USA (1996):887-901.
2. Ibba M, Soll DQuality control mechanisms during translation. Science (1999) 286:1893-1897.
3. Fuller AT, Mellows G, Woolford M, Banks GT, Barrow KD, Chain EBPseudomonic acid: An antibiotic produced by Pseudomonas fluorescens. Nature (1971) 234:416-417.
4. Konishi M, Nishio M, Saitoh K, Miyaki T, Oki T, Kawaguchi HCispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure. J Antibiot (1989) 42:1749-1755.
5. Konrad I, Roschenthaler RInhibition of phenylaianine tRNA synthetase from Bacillus subtilis by ochratoxin A. FEBS Lett (1977) 83:341 -347.
6. Ogilvie A, Wiebauer K, Kersten WInhibition of leucyltransfer ribonucleic acid synthetase in Bacillus subtilis by granaticin. Biochem J(1975) 152:511-515.
7. Paetz W, Mass GBiochemical and immunological characterization of threonyl-tRNA synthetase of two borrelidin-resistant mutants of Escherichia coll K12. Eur J Biochem (1973) 35:331-337.
8. Tanaka K, Tamaki M, Watanabe SEffect of furanomycin on the synthesis of Isoleucyl-tRNA. Biochem Biophys Acta (1969)195:244-245.
9. Werner RG, Thorpe LF, Reuter W, Nierhaus KHIndolmycin inhibits prokaryotic tryptophanyl-tRNA ligase. Eur J B/oc/7em(1976)68:1-3.
10. Hughes J, Mellows GInteraction of pseudomonlc acid A and Escherichia coll B isoleucyl-tRNA synthetase. Biochem J (1980) 191:209-219.
11. Brown JR, Doolittle WFGene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetases. J Mol Evol (W99) 49:485-495.
12. Stock JB, Ninfa AJ, Stock AMProtein phosphorylation and regulation of adaptive responses in bacteria. Microbiol Rev (1989)53:450-490.
13. Msadek TWhen the going gets tough: Survival strategies and environmental signaling networks in Bacillus subtilis. Trends Microbiol (1999) 7:201-207.
14. Miller JF, Mekalanos JJ, Falkow SCoordinate regulation and sensory transduction in the control of bacterial virulence. Science (1989) 243:916-922.
15. Novick RP, Projan SJ, Komblum J, Ross HF, Ji G, Kreiswirth B, Vandenesch F, Moghazeh SThe agr P2 operon: An autocatalytic sensory transduction system in Staphylococcus aureus. Mol Gen Genet (1995) 248:446-458.
16. Mutoh N, Simon MlNucleotide sequence corresponding to five chemotaxis genes in Escherichia coll. J Bacteriol (1986) 165:161-166.
17. Arthur M, Molinas C, Courvalin PThe VanS-VanR twocomponent regulatory system controls synthesis of depsipeptide peptidoglycan precursors In Enterococcus faecium BM4147. J Bacteriol tf 992) 174:2582-2591.
18. Barrett JF, Goldschmidt RM, Lawrence LE, Foleno B, Chen R, Demers JP, Johnson S, Kanojia R, Femandez J, Bernstein J, Licata L, Donetz A, Huang S, Hlasta DJ, Macielag MJ, Ohemeng K, Frechette R, Frosco MB, Klaubert DH, Whiteley JM, Wang L, Hoch JAAntibacterial agents that inhibit twocomponent signal transduction systems. Proc Natl Acad Sci USA (1998) 95:5317-5322.
19. Macielag MJ, Demers JP, Fraga-Spano SA, Hlasta DJ, Johnson SG, Kanojia RM, Russell RK, Sui Z, Weidner-Wells MA, Werblood H, Foleno BD, Goldschmidt RM, Loelotf MJ, Webb GC, Barrett JFSubstituted salicylanilides as inhibitors of two-component regulatory systems In bacteria. J Med Chem (1998) 41:2939-2945.
20. Hilliard JJ, Goldschmidt RM, Licata L, Baum EZ, Bush KMultiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems. Antimicrob Agents Chemother (1999) 43:1693-1699.
21. Roychoudhury S, Zielinski NA, Ninfa AJ, Allen NE, Jungheim LN, Nicas Tl, Chakrabarty AMInhibitors of two-component signal transduction systems: Inhibition of alginate gene activation in Pseudomonas aeruginosa. Proc Natl Acad Sci USA (1993) 90:965-969.
22. Ulijasz AT, Weisblum BDissecting the VanRS signal transduction pathway with specific inhibitors. J Bacteriol (1999)181:627-631.
23. Fabret C, Feher VA, Hoch JATwo-component signal transduction In Bacillus subtilis: How one organism sees its world. J Bacteriol (1999) 181:1975-1983.
24. Mizuno TCompilation of all genes encoding twocomponent phosphotransfer signal transducers in the genome of Escherichia coll. DNA Res (1997) 4:161-168.
25. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kertavage AR, Bull CJ, Tomb J-F, Dougherty BA, Merrick JM, McKenney K, Sutton G, FitzHugh W, Fields C, Gocayne JD, Scott J, Shirley R, Liu L-l, Venter JCWhole-genome random sequencing and assembly of Haemophilus influenzas Rd. Science (1995) 269:496-521.
26. Tomb J-F, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JCThe complete genome sequence of the gastric pathogen Helicobacter pylori. Nature (1997) 388:539-547.
27. Lange R, Wagner C, de Saizieu A, Flint N, Molnos J, Stieger M, Caspers P, Kamber M, Keck W, Amrein KEDomain organization and molecular characterization of 13 twocomponent systems identified by genome sequencing of Streptococcus pneumonlae. Gene (1999) 237:223-234.
28. Throup JP, Koretke KK, Bryant AP, Ingraham KA, Chalker AF, Ge Y, Marra A, Wallis NG, Brown JR, Holmes DJ, Rosenberg M, Bumham MKA genomic analysis of two-component signal transduction in Streptococcus pneumonlae. Mol Microbiol (2000) 35:566-576.
29. Martin PK, Li T, Sun D, Biek DP, Schmid MBRole in cell permeability of an essential two-component system in Staphylococcus aureus. J Bacteriol (1999) 181:3666-3673.
30. Fabret C, Hoch JAA two-component signal transduction system essential for growth of Bacillus subtilis: Implications for anti-infective therapy. J Bacteriol (1998) 180:6375-6383.
31. Bugg TD, Walsh CTIntracellular steps of bacterial cell wall peptidoglycan biosynthesis: Enzymology, antibiotics and antibiotic resistance. Nature Prod Rep (1992) 9:199-215.
32. Benson TE, Marquardt JL, Marquardt AC, Etzkom FA, Walsh CTOverexpression, purification, and mechanistic study of UDP/V-acetylenolpyruvylglucosamine reductase. Biochemistry (1993)32:2024-2030.
33. Liger D, Masson A, Blanot D, van Heijenoort J, Parquet COver-production, purification and properties of the uridinediphosphate-/V-acetylmuramate:L-alanine ligase from Escherichia coll EurJBiochem (1995) 230:80-87.
34. Brown ED, Vivas El, Walsh CT, Kolter RMurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coll. J Bacteriol (1995) 177:4194-4197.
35. Rowland SL, Errington J, Wake RGThe Bacillus subtilis cell-division 135-137 degrees region contains an essential orf with significant similarity to murB and a dispensable sfapgene. Gene (1995) 164:113-116.
36. Tanner ME, Vaganay S, van Heijenoort J, Blanot DPhosphinate inhibitors of the D-glutamic acid-adding enzyme of peptidoglycan biosynthesis. J Org Chem (1996) 61:1756-1760.
37. Gegnas LD, Waddell ST, Chabin RM, Reddy S, Wong KKInhibitors of the bacterial cell wall biosynthesis enzyme MurD. Bioorg Med Chem Lett (1998) 8:1643-1648.
38. Massidda O, Andertuzzi D, Friedii L, Feger GUnconventional organization of the division and cell wall gene cluster of Streptococcus pneumoniae. Microbiology (1998) 144:3069-3078.
39. Lowe AM, Deresiewicz RLCloning and sequencing of Staphylococcus aureus murC, a gene essential for cell wall biosynthesis. DMA Sequence (1999) 1:19-23.
40. El-Sherbeini M, Geissler WM, Pittman J, Yuan X, Wong KK, Pompliano DLCloning and expression of Staphylococcus aureus and Streptococcus pyogenes murD genes encoding uridine diphosphate W-acetylmuramoyl-L-alanine:D-glutamate ligases. Gene (1998) 210:117-125.
41. Wong KK, Kuo DW, Chabin RM, Foumier C, Gegnas LD, Waddell ST, Marsilio F, Letting B, Pompliano DLEngineering a cell-free murein biosynthetic pathway: Combinatorial enzymology in drug discovery. J Am Chem Soc (1998) 120:13527-13528.
42. Men H, Park P, Ge M, Walker SSubstrate synthesis and activity assay for MurG. JAm Chem Soc (1998) 120:2484-2485.
43. Magnuson K, Jackowski S, Rock CO, Cronan JERegulation of fatty acid biosynthesis in Escherichia coli. Microbiol Rev (1993)57:522-542.
44. Omura SCerulenin. Methods Enzymol (1981 ) 72:520-532.
45. Miyakawa S, Suzuki K, Noto T, Harada Y, Okazaki HThiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice. J Antibiot (1982) 35:411-419.
46. Tumowsky F, Fuchs K, Jeschek C, Hogenauer G: envM Genes of Salmonella typhimurium and Escherichia coll. J Bacterio/(1989) 171:6555-6565.
47. Heath RJ, Rock COEnoyi-acyl carrier protein reductase (fabl) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coll. J Biol Chem (1995) 270:26538-26542.
48. Baldock C, Ratferty JB, Sedelnikova SE, Baker PJ, Stuitje AR, Slabas AR, Hawkes TR, Rice DWA mechanism of drug action revealed by structural studies of enoyl reductase. Science (1996) 274:2107-2110.
49. McMurry LM, Oethinger M, Levy SBTriclosan targets lipid synthesis. Nature (1998) 394:531-532.
50. Heath RJ, Yu YT, Shapiro MA, Oison E, Rock COBroad spectrum antimicrobial biocides target the Fabl component of fatty acid synthesis. J Biol Chem (1998) 273:30316-30320.
51. Lin AH, McCroskey MC, Choi G, Curry KA, Marotti KRThe cloning, expression, purification and characterization of the S aureus malonyl coenzyme A-Acyl carrier protein transacylase. 99th American Society of Microbiology General Meeting, Chicago, IL, USA (1999):K-119.
52. Kutchma AJ, Hoang TT, Schweizer HPCharacterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: Purification of acyl carrier protein (ACP) and malonyl-coenzyme A: ACP transacylase (Fab D). J Bacteriol (1999)181:5498-5504.
53. Hoang TT, Schweizer HPCharacterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (Fabl): A target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis. J Bacteriol (1999) 181:5489-5497.
54. Payne DJ, DeWolf WE, Gentry DG, Kauender H, Pearce KH, Pearson SCIdentification and characterization of the S aureus Fab I (enoyl-ACP reductase). 99th American Society of Microbiology General Meeting, Chicago, IL, USA (1999):K-131.
55. Ward WH, Holdgate GA, Rowsell S, McLean EG, Paupit RA, Clayton E, Nichols WW, Colls JG, Minshull CA, Jude DA, Mistry A, Timms D, Gamble R, Hales NJ, Britton CJ, Taylor IWKinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan. Biochemistry (1999) 38:12514-12525.
56. Qiu X, Janson CA, Court Rl, Smyth MG, Payne DJ, Abdel-Meguid SSMolecular basis of triclosan activity involves a flipping loop in the active she. Protein Sci (1999) 8:2529-2532.
57. Heath RJ, Rubin JR, Holland DR, Zhang E, Snow ME, Rock COMechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem (1999) 274:11110-11114.
58. Levy CW, Roujeinikova A, Sedelnikova S, Baker PJ, Stuitje AR, Slabas AR, Rice DW, Rafferty JBMolecular basis of triclosan activity. Nature (1999) 398:383-384.
59. Moche M, Schneider G, Edwards P, Dehesh K, Lindqvist YStructure of the complex between the antibiotic cerulenin and its target, -ketoacyl-acyl carrier protein synthase. J Biol Chem (1999) 274:6031-6034.
60. Moral CH, Del Castillo EF, Fierro PL, Cortes AV, Castillo JA, Soriano AC, Salazar MS, Peralta BR, Carrasco GNMolecular characterization of the Aeromonas hydrophile aroA gene and potential use of an auxotrophic aroA mutant as a live attenuated vaccine. Infect Immun (1988) 66:1813-1821.
61. Coma! L, Sen LC, Stalker DMAn altered aroA gene product confers resistance to the herbicide glyphosate. Science (1983)221:370-371.
62. Davies GM, Barrett-Bee KJ, Jude DA, Lehan M, Nichols WW, Pinder PE, Thain JL, Watkins WJ, Wilson RG: (6S)-6-fluorcshlkimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway. Antimicrob Agents Chemother(W94) 38:403-406.
63. Bomemann S, Ramjee MK, Balasubramanian S, Abell C, Coggins JR, Lowe DJ, Thomeley RNEscherichla coli chorismate synthase catalyzes the conversion of (6S)-6fluoro-S-enolpyruvylshikimate-3-phosphate to 6fluorochorismate. J Biol Chem (1995) 270:22811-22815.
64. Ewart CD, Jude DA, Thain JL, Nichols WWFrequency and mechanism of resistance to antibacterial action of ZM 240401, (6S)-6-fluoro-shikimic acid. Antimicrob Agents Chemother(1Q9S) 39:87-93.
65. Du W, Wallis NG. Mazzulla MJ, Chalker AF, Zhang L, Uu W-S, Kallender H, Payne DJ: Characterization of Streptococcus pneumonlae 5-enolpyruvylshikimate-3-phosphate synthase and its activation by monovalent cations. Eur J Biochem (1999)266:1-7.
66. SMITHKLINE BEECHAM PLC (Hodgson JE, Walüs NGTCSTS polynucleotides. US-05854020 (1998).
67. SMITHKLINE BEECHAM PLC (Wallis NG, Hodgson JETwo-component signal transduction response regulator polypeptides from Staphylococcus aureus. WO-09723504 (1997).
68. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Wallis NG, Shilling LK, Warren RLHistidine kinase from Staphylococcus aureus. EP-00857787 (1998).
69. SMITHKUNE BEECHAM CORP/SMITHKUNE BEECHAM PLC (Wallis NG, Shilling LK, Wang M, Jaworski DD, Ingraham KA, Ray J, Chalker AF, Holmes DJ, Zalacain M, Brown JR, Biswas SMurB gene from Streptococcus pneumoniae. EP-00911403 (1999).
70. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Fueyo JL, Lonetto MA, Wallis NGMurD from Streptococcus pneumoniae. EP-00906956 (1999).
71. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Wallis NGMurE gene encoding uridine-diphosphate-Wacetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase of Streptococcus pneumoniae. EP-00908518 (1999).
72. ELI LILLY AND COMPANY (Hoskins JA, Skatrud PL, Peery RB)Biosynthetic gene murG from Streptococcus pneumoniae. EP-00843012(1998).
73. SMITHKUNE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Wallis NG, Fedon JC, Palmer LM, Shilling LKMurB gene from Staphylococcus aureus. EP-00899335 (1999).
74. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Wallis NG, Bumham MKR)MurC gene of Staphylococcus aureus coding for UDP-W-acetylmuramate:L-alanine ligase EP00889123(1999).
75. SMITHKLINE BEECHAM CORP (Wallis NG)MurF polynucleotides and polypeptides from Staphylococcus. EP-00905247(1999).
76. SMITHKLINE BEECHAM CORP (Debouck C, Gentry DR, Lonsdale JT, Mooney JL, Payne DJ, Pearson SC, Shilling LK, Van Aller G, Wang M, Zhong YYFabH from Stephylococcus aureus. EP-00916730 (1999).
77. SMITHKLINE BEECHAM CORP (Lonsdale J, Payne DJ, Pearson SC, Milner PHStaphylococcal Fab I enoyl-ACP reductase. EP-00826774(1998).
78. SMITHKLINE BEECHAM CORP (Gentry DR, Lonsdale JT, Payne DJ, Pearson SCStaphylococcus FabD (malonylCoA:ACP transacylase) protein. EP-00843016 (1998).
79. SMITHKLINE BEECHAM CORP (Gentry DR, Lonsdale JT, Payne DJ, Pearson SC, Van Aller GNovel FabD. WO-09822133 (1998).
80. SMITHKLINE BEECHAM CORP (Gentry DR, Lonsdale JT, Payne DJ, Pearson SCNovel FabH. WO-09817779 (1998).
81. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Black MT, Bumham MK, Hodgson JE, Knowles DJ, Nicholas RO, Pratt JM, Reichard RW, Rosenberg M, Ward JM, Lonetto MA, Warren PV, Payne DJ, Brown JRNovel 3-dehydroqulnate synthase. EP-00832978 (1998).
82. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Brown JR, Bumham MK, Payne DJ, Traini CM, Wang M): aroE shikmate 5 dehydrogenase from Staphylococcus aureus. EP-00861895 (1998).
83. SMITHKLINE BEECHAM (Burhham MKStreptococcus pneumoniae aroE polypeptides and polynucleotldes. EP-00854188(1998).
84. SMITHKLINE BEECHAM CORP/SMITHKLINE BEECHAM PLC (Payne DJ, Chalker A, Brown J): 3-Dehydroquinate synthase (aroB). EP-00874053 (1998).
85. SMITHKLINE BEECHAM CORP (Payne DJ, Chalker AF, Brown JR, Ingraham KA, Holmes DJ, Marra A, Bryant A, Zalacain M, Biswas SChorismate synthase. EP-00913480 (1999).
86. SMITHKLINE BEECHAM CORP (Brown JR, Chalker AF, Payne DJ, Shilling LK, Traini CMAroA. US-05883239 (1999).