Dissecting the VanRS signal transduction pathway with specific inhibitors

Journal of Bacteriology

Volumn 181, Issue 2, 1999, Pages 627-631

  Ulijasz, Andrew T ^a   Weisblum, Bernard ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; EFFECTOR CELL; ENTEROCOCCUS FAECIUM; ENZYME RECONSTITUTION; GENE CLUSTER; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ENTEROCOCCUS FAECIUM; POSIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0032943588     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.2.627-631.1999     Document Type: Article

References (17)

1. Arthur, M., C. Molinas, and P. Courvalin. 1992. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 174:2582-2591.
2. Barrett, J. F., R. M. Goldschmidt, L. E. Lawrence, B. Foleno, R. Chen, J. P. Demers, S. Johnson, R. Kanojia, J. Fernandez, J. Bernstein, L. Licata, A. Donetz, S. Huang, D. J. Hlasta, M. J. Macielag, K. Ohemeng, R. Frechette, M. B. Frosco, D. H. Klaubert, J. M. Whiteley, L. Wang, and J. A. Hoch. 1998. Antibacterial agents that inhibit two-component signal transduction systems. Proc. Natl. Acad. Sci. USA 95:5317-5322.
3. Barrett, J. F., and J. A. Hoch. 1998. Two-component signal transduction as a target for microbial anti-infective therapy. Antimicrob. Agents Chemother. 42:1529-1536.
4. Fisher, S. L., S.-K. Kim, B. L. Wanner, and C. T. Walsh. 1996. Kinetic comparison of the specificity of the vancomycin resistance kinase VanS for two response regulators, VanR amd PhoB. Biochemistry 35:4732-4740.
5. Haldimann. A., S. L. Fisher, L. L. Daniels, C. T. Walsh, and B. L. Wanner. 1997. Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12. J. Bacteriol. 179:5903-5913.
6. Holman, T. R., Z. Wu, B. L. Wanner, and C. T. Walsh. 1994. Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium. Biochemistry 33:4625-4631.
7. Igo, M. M., A. J. Ninfa, J. B. Stock, and T. J. Silhavy. 1989. Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor. Genes Dev. 3:1725-1734.
8. Jung, K., B. Tjaden, and K. Altendorf. 1997. Purification, reconstitution, and characterization of KdpD, the turgor sensor of Escherichia coli. J. Biol. Chem. 272:10847-10852.
9. Kovalic, D., R. B. Giannattasio, H. J. Jin, and B. Weisblum. 1994. 23S rRNA domain V, a fragment that can be specifically methylated in vitro by the ErmSF (TIrA) methyltransferase. J. Bacteriol. 176:6992-6998.
10. Mizuno, T. 1998. His-Asp phosphotransfer signal transduction. J. Biochem. 123:555-563.
11. Rampersaud, A., R. Utsumi, J. Delgado, S. A. Forst, and M. Inouye. 1991. Ca2(+)-enhanced phosphorylation of a chimeric protein kinase involved with bacterial signal transduction. J. Biol. Chem. 266:7633-7637.
12. Roychoudhury, S., N. A. Zielinski, A. J. Ninfa, N. E. Allen, L. N. Jungheim, T. I. Nicas, and A. M. Chakrabarty. 1993. Inhibitors of two-component signal transduction systems: inhibition of alginate gene activation in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 90:965-969.
13. Studier, F. W., A. H. Rosenberg, J. J. Dunn, and J. W. Dubendorff. 1990. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185:60-89.
14. Tokishita, S., A. Kojima, H. Aiba, and T. Mizuno. 1991. Transmembrane signal transduction and osmoregulation in Escherichia coli. Functional significance of the periplasmic domain of the membrane-located protein kinase, EnvZ. J. Biol. Chem. 266:6780-6785.
15. Ulijasz, A. T., A. Grenader, and B. Weisblum. 1996. A vancomycin-inducible LacZ reporter system in Bacillus subtilis: induction by antibiotics that affect cell wall synthesis. J. Bacteriol. 178:6305-6309.
16. Wanner, B. L. 1992. Is cross regulation by phosphorylation of two-component response regulator proteins important in bacteria? J. Bacteriol. 174: 2053-2058.
17. Wright, G. D., T. R. Holman, and C. T. Walsh. 1993. Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry 32:5057-5063.