A mechanism of drug action revealed by structural studies of Enoyl reductase

Science

Volumn 274, Issue 5295, 1996, Pages 2107-2110

  Baldock, Clair ^a   Rafferty, John B ^a   Sedelnikova, Svetlana E ^a   Baker, Patrick J ^a   Stuitje, Antoine R ^b   Slabas, Antoni R ^c   Hawkes, Timothy R ^d   Rice, David W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c DURHAM UNIVERSITY   (United Kingdom)

^d JEALOTT S HILL RESEARCH STATION   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISONIAZID; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; COVALENT BOND; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE TARGETING; GENETIC LINKAGE; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BINDING SITES; BORON COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHETASE COMPLEX; HYDROGEN BONDING; MODELS, MOLECULAR; NAD; OXIDOREDUCTASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

ANIMALIA; ESCHERICHIA; ESCHERICHIA COLI;

EID: 0030452311     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5295.2107     Document Type: Article

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33. We thank the support staff at the Synchrotron Radiation Source at Daresbury Laboratory for assistance with station alignment. Supported by grants from the UK Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (D.W.R. and A.R.S.). C.B. is funded by a Zeneca Agrochemicals - supported CASE award. J.B.R. is a BBSRC David Phillips Research Fellow. The Krebs Institute is a designated BBSRC Biomolecular Science Centre.