Epidermal stem cells: Markers, patterning and the control of stem cell fate

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 353, Issue 1370, 1998, Pages 831-837

  Watt, Fiona M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

C Myc; Cadherins; Epidermis; Integrins; Keratinocytes; Stem cells

Indexed keywords

DISPERSAL; DOMINANCE; REPRODUCTION; RODENT; SOCIAL INTERACTION;

ANIMALIA; MUS; MUS MUSCULUS DOMESTICUS; MUSCULUS; RODENTIA;

EID: 0032577990     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1998.0247     Document Type: Article

References (52)

1. Aberle, H., Schwartz, H. & Kemler, R. 1996 Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell. Biochem. 61, 514-523.
2. Adams, J. C. & Watt, F. M. 1989 Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature 340, 307-309.
3. 1 integrin loss from the cell surface. Cell 63, 425-435.
4. 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J. Cell Biol. 115, 829-841.
5. A1-Bawari, S. E. & Potten, C. S. 1976 Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. Int. J. Radiat. Biol. 30, 201-216.
6. Amati, B. & Land, H. 1994 Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr. Opin. Genet. Dev. 4, 102-108.
7. Barrandon, Y. & Green, H. 1987 Three clonal types of keratinocyte with different capacities for multiplication. Proc. Natn. Acad. Sci. USA 84, 2302-2306.
8. Earth, A. I. M., Nathke, I. S. & Nelson, W. J. 1997 Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr. Opin. Cell Biol. 9, 683-690.
9. Compton, C. C., Gill, J. M., Bradford, D. A., Regauer, S., Gallico, G. G. & O'Connor, N. E. 1989 Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting: a light, electron microscopic and immunohistochemical study. Lab. Infest. 60, 600-612.
10. Cotsarelis, G., Cheng, S.-Z., Dong, G., Sun, T.-T. & Lavker, R. M. 1989 Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57, 201-209.
11. Cotsarelis, G., Sun, T.-T. & Lavker, R. M. 1990 Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61, 1329-1337.
12. DePinho, R. A., Schreiber-Agus, N. & Alt, F. W. 1991 Myc family oncogenes in the development of normal and neoplastic cells. Adv. Cancer Res. 57, 1-46.
13. Dover, R. & Potten, G. S. 1983 Cell cycle kinetics of cultured human epidermal keratinocytes. J. Invest. Dermatol. 80, 423-429.
14. Gallico, G. G. III, O'Connor, N. E., Compton, C. C., Kehinde, O. & Green, H. 1984 Permanent coverage of large skin wounds with autologous cultured epithelium. N. Engl. J. Med. 311, 448-451.
15. Gandarillas, A. & Watt, F. M. 1995 Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes. Oncogene 11, 1403-1407.
16. Gandarillas, A. & Watt, F. M. 1997 c-Myc promotes differentiation of human epidermal stem cells. Genes Devt 11, 2869-2882.
17. Green, H. & Barrandon, Y. 1988 Cultured epidermal cells and their use in the generation of epidermis. News Physiol. Sci. 3, 53-56.
18. Gumbiner, B. M. 1995 Signal transduction by β-catenin. Curr. Opin. Cell Biol. 7, 634-640.
19. Hall, P. A. & Watt, F. M. 1989 Stem cells: the generation and maintenance of cellular diversity. Development 106, 619-633.
20. Harrington, E. A., Fanidi, A. & Evan, G. I. 1994 Oncogenes and cell death. Curr. Opin. Genet. Dev. 4, 120-129.
21. Hodivala, K. J. & Watt, F. M. 1994 Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J. Cell Biol. 124, 589-600.
22. 1 integrin levels during keratinocyte terminal differentiation. J. Cell Biol. 128, 1209-1219.
23. Hurlin, P. J., Foley, K. P., Ayer, D. E., Eisenman, R. N., Hanahan, D. & Arbeit, J. M. 1995a Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. Oncogene 11, 2487-2501.
24. Hurlin, P. J., Quéva, C., Koskinen, P. J., Steingrímsson, E., Ayer, D. E., Copeland, N. G., Jenkins, N. A. & Eisenman, R. N. 1995b Mad 3 and Mad 4: novel Max-interacting transcriptional repressors that surpress c-Myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14, 5646-5659.
25. Jonason, A. S., Kunala, S., Price, G. J., Restifo, R. J., Spinelli, H. M., Persing, J. A., Leffell, D. J., Tarone, R. E. & Brash, D. E. 1996 Frequent clones of p53-mutated keratinocytes in normal human skin. Proc. Natn. Acad. Sci. USA 93, 14 025-14 029.
26. Jones, P. H. 1997 Epithelial stem cells. BioEssays 19, 683-690.
27. Jones, P. H. & Watt, F. M. 1993 Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73, 713-724.
28. Jones, P. H., Harper, S. & Watt, F. M. 1995 Stem cell patterning and fate in human epidermis. Cell 80, 83-93.
29. 1 integrin subunit. Oncogene 11, 2599-2607.
30. 1. Oncogene 14, 1341-1350.
31. Karccla, P. L.Timpl, R. & Watt, F. M. 1994 Adhesion of human epidermal kertinocytes to laminin. Cell Adhesion Commun. 2, 309-318.
32. Lajtha, L. G. 1979 Stem cell concepts. Differentiation 14, 23-34.
33. Lane, E. B., Wilson, C. A., Hughes, B. R. &' Leigh, I. M. 1991 Stem cells in hair follicles: cytoskeletal studies. Ann. NY Acad. Sci. 642, 197-213.
34. Lavker, R. M. & Sun, T. T. 1982 Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations. Science 215, 1239-1241.
35. Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G. & Evan, G. I. 1995 A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucl. Acids Res. 23, 1686-1690.
36. Miller, S. J., Burke, E. M., Rader, M. D., Coulombe, P. A. & Lavker, R. M. 1998 Re-epithelialization of porcine skin by the sweat apparatus. J. Incest. Dermatol. 110, 13-19.
37. Moles, J.-P. & Watt, F. M. 1997 The epidermal stem cell compartment: variation in expression levels of E-cadherin and catenins within the basal layer of human epidermis. J. Histochem. Cytochem. 45, 867-874.
38. Morris, R. J. & Potten, C. S. 1994 Slowly cycling (label-retaining) epidermal cells behave like clonogenic stem cells in vitro. Cell Proliferation 27, 279-289.
39. Penneys, N. S., Fulton, E. Jr, Weinstein, G. D. & Frost, P. 1970 Location of proliferating cells in human epidermis. Arch. Derm. 101, 323-327.
40. Potten, C. S. 1974 The epidermal proliferative unit: the possible role of the central basal cell. Cell Tissue Kinet. 7, 77-88.
41. Potten, C. S. 1981 Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation. Int. Rev. Cytol. 69, 271-318.
42. Potten, C. S. & Hendry, J. H. 1973 Clonogenic cells and stem cells in the epidermis. Int. J. Radial. Biol. 24, 537-540.
43. Potten, C. S. & Morris, R. J. 1988 Epithelial stem cells in vivo. J. Cell Sci. 10 (Suppl.), 45-62.
44. Reynolds, A. J, & Jahoda, C. 1992 Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development 115, 587-593.
45. Rochat, A., Kobayashi, K. & Barrandon, Y. 1994 Location of stem cells of human hair follicles by clonal analysis. Cell 76, 1063-1073.
46. Schofield, R. 1978 The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4, 7-25.
47. 3H]thymidine incorporation and immunoperoxidase staining of 67K polypeptide. Dr. J. Dermatol. 108, 433-439.
48. Watt, F. M. & Hertle, M. D. 1994 Keratinocyte integrins. In The keratinocyte handbook (ed. I. M. Leigh, E. B. Lane & F. M. Watt), pp. 153-164. Cambridge University Press.
49. Watt, F. M., Kubler, M.-D., Hotchin, N. A., Nicholson, L. J. & Adams, J. C. 1993 Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions, J. Cell Sci. 106, 175-182.
50. Withers, H. R. 1967 Recovery and repopulation in vivo by mouse skin epithelial cells during fractionated irradiation. Radiat. Res. 32, 227-239.
51. Yang, J.-S., Lavker, R. M. & Sun, T.-T. 1993 Upper human hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential. J. Invest. Dermatol. 101, 652-659.
52. Zhu, A. J. & Watt, F. M. 1996 Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J. Cell Sci. 109, 3013-3023.