Congo red inhibits proteoglycan and serum amyloid P binding to amyloid β fibrils

Journal of Neurochemistry

Volumn 70, Issue 1, 1998, Pages 292-298

  Gupta Bansal, Rekha ^a   Brunden, Kurt R ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Alzheimer's disease; Amyloid ; Congo red; Proteoglycan; Serum amyloid P

Indexed keywords

AMYLOID BETA PROTEIN; CONGO RED; PROTEOGLYCAN; SERUM AMYLOID P;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SENILE PLAQUE;

ANIMALIA;

EID: 0031973005     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70010292.x     Document Type: Article

References (40)

1. Ard M. D., Cole G. M., Wei J., Mehrle A. P., and Fratkin J. D. (1996) Scavenging of Alzheimer's amyloid β-protein by microglia in culture. J. Neurosci. Res. 43, 190-202.
2. Botto M., Hawkins P. N., Bickerstaff M. C. M., Herbert J., Bygrave A. E., McBride A., Hutchinson W. L., Tennent G. A., Walport M. J., and Pepys M. B. (1997) Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene. Nat. Med. 3, 855-859.
3. Brunden K. R., Richter-Cook N. J., Chaturvedi N., and Frederickson R. C. A. (1993) pH-dependent binding of synthetic β-amyloid peptides to glycosaminoglycans. J. Neurochem. 61, 2147-2154.
4. Buee L., Ding W., Anderson J. P., Narindrasorasak S., Kisilevsky R., Boyle N. J., Robakis N., Delacourte A., Greenberg B., and Fillit H. M. (1993) Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide. Brain Res. 627, 199-204.
5. Burgevin M.-C., Passat M., Daniel N., Capet M., and Doble A. (1994) Congo red protects against toxicity of β-amyloid peptides on rat hippocampal neurones. Neuroreport 5, 2429-2432.
6. Cai X.-D., Golde T. E., and Younkin S. G. (1993) Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259, 514-516.
7. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A. Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., and Selkoe D. J. (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360, 672-674.
8. Citron M., Diehl T. S., Gordon G., Biere A. L., Seubert P., and Selkoe D. J. (1996) Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities. Proc. Natl. Acad. Sci. USA 93, 13170-13175.
9. DeWitt D. A., Silver J., Canning D. R., and Perry G. (1993) Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease. Exp. Neurol. 121, 149-152.
10. Duff K., Eckman C., Zehr C., Yu X., Prada C.-M., Perez-Tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M. N., Holcomb L., Refolo L., Zenk B., Hardy J., and Younkin S. (1996) Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
11. Glenner G. G. and Wong C. W. (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 120, 885-890.
12. Goldgaber D., Lerman M. I., McBride O. W., Saffiotti U., and Gajdusek D. C. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
13. Gravino S. A., Ho L., Eckman C. B., Long K. E., Otvos L. J., Younkin L. H., Suzuki N., and Younkin S. G. (1995) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. J. Biol. Chem. 270, 254-259.
14. Gupta-Bansal R., Frederickson R. C. A., and Brunden K. R. (1995) Proteoglycan-mediated inhibition of Aβ proteolysis: a potential cause of senile plaque accumulation. J. Biol. Chem. 270, 18666-18671.
15. ++-dependent binding of human serum amyloid P component to Alzheimer's β-amyloid peptide. J. Biol. Chem. 270, 10392-10394.
16. Hascall V. C. and Kimura J. (1982) Proteoglycans: isolation and characterization. Methods Enzymol. 82, 769-800.
17. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K., and Muller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
18. Kinoshita C. M., Gewurz A. T., Siegel J. N., Ying S.-C., Hugli T. E., Coe J. E., Gupta R. K., Huchman R., and Gewurz H. (1992) A protease-sensitive site in the proposed Ca(2+(-binding region of human serum amyloid P component and other pentraxins. Protein Sci. 1, 700-709.
19. Klunk W. E., Pettegrew J. W., and Abraham D. J. (1989) Quantitative evaluation of Congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. J. Histochem. Cytochem. 37, 1273-1281.
20. Klunk W. E., Debnath M. L., and Pettegrew J. W. (1994) Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease. Neurobiol. Aging 15, 691-698.
21. LeVine H. (1993) Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci. 2, 404-410.
22. LeVine H. (1995) Thioflavine T interaction with amyloid β-sheet structures. Amyloid: Int. J. Exp. Clin. Invest. 2, 1-6.
23. Levy-Lahad E., Wasco W., Poorkaj P., Romano D. M., Oshima J., Pettingell W. H., Yu C., Jondro P. D., Schmidt S. D., Wang K., Crowley A. C., Fu Y.-H., Guenette S. Y., Galas D., Nemens E., Wijsman E. M., Bird T. D., Schellenberg G., and Tanzi R. E. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
24. Lorenzo A. and Yankner B. A. (1994) β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91, 12243-12247.
25. Robakis N. K., Ramakrishna N., Wolfe G., and Wisniewski H. M. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc. Natl. Acad. Sci. USA 84, 4190-4194.
26. Schagger H. and von Jagow G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166, 368-379.
27. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T. D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., and Younkin S. (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
28. Shaffer L. M., Dority M. D., Gupta-Bansal R., Frederickson R. C. A., Younkin S. G., and Brunden K., R. (1995) Amyloid β protein (Aβ) removal by neuroglial cells in culture. Neurobiol. Aging 16, 737-745.
29. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R. J., Wasco W., Da Silva H. A. R., Haines J. L., Pericak-Vance M. A., Tanzi R. E., Roses A. D., Fraser P. E., Rommens J. M., and St. George-Hyslop P. H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
30. Simmons L. K., May P. C., Tomaselli K. J., Rydel R. E., Fuson K. S., Brigham E. F., Wright S., Lieberburg I., Becker G. W., Brems D. N., and Li W. Y. (1994) Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro. Mol. Pharmacol. 45, 373-379.
31. Snow A. D. and Wight T. N. (1989) Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses. Neurobiol. Aging 10, 481-497.
32. Snow A. D., Mar H., Nochlin D., Kimata K., Kato M., Suzuki S., Hassell J., and Wight T. N. (1988) The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy of Alzheimer's disease. Am. J. Pathol. 133, 456-463.
33. Snow A. D., Henderson M., Nochlin D., Kresse H., and Wight T. N. (1992) Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease. J. Histochem. Cytochem. 40, 105-113.
34. Snow A. D., Sekiguchi R., Nochlin D., Fraser P., Kimata K., Mizutani A., Arai M., Schreier W. A., and Morgan D. G. (1994) An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain. Neuron 12, 219-234.
35. Snow A. D., Kinsella M. G., Parks E., Sekiguchi R. T., Miller J. D., Kimata K., and Wight T. N. (1995) Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin and versican) to the beta-amyloid protein of Alzheimer's disease. Arch. Biochem. Biophys. 320, 84-95.
36. Soto C., Castano E. M., Kumar R. A., Beavis R. C., and Frangione B. (1995) Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure. Neurosci. Lett. 200, 105-108.
37. Suzuki N., Cheung T. T., Cai X.-D., Odaka A., Otvos L., Eckman C, Golde T. E., and Younkin S. G. (1994) An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants. Science 264, 1336-1340.
38. Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A. P., St. George-Hyslop P., Van Keuren M. L., Patterson D., Pagan S., Kumit D. M., and Neve R. L. (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880-884.
39. Tennent H. A., Lovat L. B., and Pepys M. B. (1995) Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. Proc. Natl. Acad. Sci. USA 92, 4299-4303.
40. Wood S. J., Maleeff B., Hart T., and Wetzel R. (1996) Physical, morphological and functional differences between pH 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta. J. Mol. Biol. 256, 870-877.