Phosphatidylinositol and inositol involvement in Alzheimer amyloid-β fibril growth and arrest

Journal of Molecular Biology

Volumn 278, Issue 1, 1998, Pages 183-194

  McLaurin, J ^b,c   Franklin, T ^a   Chakrabartty, A ^b,c   Fraser, P E ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c Department of Medical Biophysics ^*  (Canada)

Author keywords

Alzheimer's disease; Amyloid; Circular dichroism; Electron microscopy; Phosphatidylinositol

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; INOSITOL; LIPID; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PHOSPHATIDYLINOSITOL; TYROSINE;

ALZHEIMER DISEASE; ARTICLE; CIRCULAR DICHROISM; ELECTRON MICROSCOPY; FIBER; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; NEUROTOXICITY; PATHOLOGY; PH; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION;

EID: 0032562547     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1677     Document Type: Article

References (57)

1. Barrow C.J., Zagorski M.G. Structure of beta peptide and its constituent fragments; relation to amyloid deposition. Science. 253:1991;179-182
2. Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., Slunt H.H., Wang R., Seeger M., Levey A.I., Gandy S.E., Copeland N.G., Jenkins N.A., Price D.L., Younkin S.G., Sisodia S.S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/ 1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013
3. Brunden K.R., Richter-Cook N.J., Chaturvedi N., Frederickson R.C.A. pH-dependent binding of synthetic β-amyloid peptides to glycosaminoglycans. J. Neurochem. 61:1993;2147-2154
4. Cai X.-D., Golde T.E., Younkin G.S. Release of excess amyloid beta protein from a mutant amyloid beta precursor. Science. 259:1993;514-516
5. Choi-Miura N.H., Ihara Y., Fukuchi K., Takeda M., Nakano Y., Tobe T., Tomita M. SP-40,40 is a constituent of Alzheimer's amyloid. Acta Neuropathol. 83:1991;260-264
6. Citron M., Vigo-Pelfrey C., Teplow D.B., Miller C., Schenk D., Johnston J., Winblad B., Venizelos N., Lannfelt L., Selkoe D. Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proc. Natl Acad. Sci. USA. 91:1994;11993-11997
7. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St George-Hyslop P., Selkoe D.J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3:1997;67-72
8. Duff K., Eckman C., ZehrC YuX., Prada C.-M., Perez-tur J., Hutton M., Buce L., Harigaya Y., Yager D., Morgan D., Gordon M.N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-β-42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713
9. Eriksson S., Janciauskiene S., Lannfelt L. α1-antichymotrypsin regulates Alzheimer β-amyloid peptide fibril formation. Proc. Natl Acad. Sci. USA. 92:1995;2313-2317
10. Esch F., Keim P.S., Beattie E.C., Blacher R.W., Culwell A.R. Cleavage of amyloid β peptide during constitutive processing of its precursor. Science. 248:1990;1122-1128
11. Evans K.C., Berger E.P., Cho C.-G., Weisgraber K.H., Lansbury P.T. Jr. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation implications for the pathogenesis and treatment of Alzheimer disease. Proc. Natl Acad. Sci. USA. 92:1995;763-767
12. Fraser P.E., Nguyen J.T., Surewicz W.K., Kirschner D.A. pH-dependent structural transitions of Alzheimer amyloid peptides. Biophys. J. 60:1991;1190-1201
13. Fraser P.E., Nguyen J.T., Chin D.T., Kirschner D.A. Effects of sulfate ions on Alzheimer β/A4 peptide assemblies implications for amyloid fibril-proteoglycan interactions. J. Neurochem. 59:1992;1531-1540
14. Fraser P.E., Nguyen J.T., McLachlan D.R., Abraham C.R., Kirschner D.A. Alpha 1-antichymotrypsin binding to Alzheimer Aβ peptides is sequence specific and induces fibril disaggregationin vitro. J. Neurochem. 61:1993;298-305
15. Fukumoto H., Asami-Odaka A., Suzuki N., Iwatsubo T. Amyloid β protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Am. J. Pathol. 148:1996;259-265
16. Ghanta J., Shen C.-L., Kidssling L.L., Murphy R.M. A strategy for designing inhibitors of β-amyloid toxicity. J. Biol. Chem. 271:1996;29525-29528
17. Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706
18. Gravina S.A., Ho L., Eckman C.B., Long K.E., Otvos L., Younkin L.H., Suzuki N., Younkin S.G. Amyloid β protein (Aβ) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms of Aβ40 and Aβ42(43). J. Biol. Chem. 270:1995;7013-7016
19. Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., Selkoe D.J. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature. 359:1992;322-325
20. Halverson K., Fraser P.E., Kirschner D.A., Lansbury P.T. Molecular determinants of amyloid deposition in Alzheimer's disease conformational studies of synthetic β-protein fragments. Biochemistry. 29:1990;2639-2644
21. Hamazaki H. Amyloid P component promotes aggregation of Alzheimer's β-amyloid peptide. Biochem. Biophys. Res. Commun. 120:1995;885-890
22. Hilbich C., Kisters-Woike B., Reed J., Masters C.L., Beyreuther K. Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease. J. Mol. Biol. 218:1991;149-163
23. Howlett D.R., Jennings K.H., Lee D.C., Clark M.S.G., Brown F., Wetzel R., Wood S., Camilleri P., Roberts G.W. Aggregation state and neurotoxic properties of Alzheimer's β-amyloid peptide. Neurodegeneration. 4:1995;23-32
24. Irvine R., Cullen P. Inositol phosphates-whither bound? Intracellular signalling. Curr. Biol. 6:1996;537-540
25. Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals Evidence that an initially deposited species is Aβ42(43). Neuron. 13:1994;45-53
26. Jarrett J.T., Lansbury P.T. Seeding one-dimensional crystallization of amyloid a pathogenic mechanism in Alzheimer's disease and Scrapie? Cell. 73:1993;1055-1058
27. Jarrett J.T., Berger E.P., Lansbury P.T. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation implications for the pathogenesis of Alzheimer's disease. Biochemistry. 32:1993;4693-4697
28. Kirschner D.A., Abraham C., Selkoe D.J. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer's Disease indicates cross-β conformation. Proc. Natl Acad. Sci. USA. 83:1986;503-507
29. Lansbury P.T., Costa P.R., Griffiths J.M., Simon E.J., Auger M., Halverson K.J., Kocisko D.A., Hendsch Z.S., Ashburn T.T., Spencer R.G.S., Tidor B., Griffin R.G. Structural model for the β-amyloid fibril based on interstrand alignment of an anti-parallel-sheet comprising a C-terminal peptide. Nature Struct. Biol. 2:1995;990-997
30. Lomakin A., Chung D.S., Benedek G.B., Kirschner D.A., Teplow D.B. On the nucleation and growth of amyloid β-protein fibrils Detection of nuclei and quantitation of rate constants. Proc. Natl Acad. Sci. USA. 93:1996;1125-1129
31. Lorenzo A., Yankner B. β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl Acad. Sci. USA. 91:1994;12243-12247
32. Masters C.L., Beyreuther K. Molecular neuropathology of Alzheimer's disease. Arzneimittel-Forschung. 45:1995;. 410-2
33. Masters C.L., Simms G., Weinman N.A., Multhaupm G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl Acad. Sci. USA. 82:1985;4245-4249
34. Mattson M.P., Tomaselli K.J., Rydel R.E. Calcium-destabilizing and neurodegeneration effects of aggregated β-amyloid peptide are attenuated by basic FGF. Brain Res. 621:1993;35-49
35. McGeer P.L., Kawamata T., Walker D.G. Distribution of clusterin in Alzheimer brain tissue. Brain Res. 579:1992;337-341
36. McLaurin J., Chakrabartty A. Membrane disruption by Alzheimer β-amyloid peptides mediated by specific binding to either phospholipids or gangliosides implications for neurotoxicity. J. Biol. Chem. 271:1996;26482-26489
37. McLaurin J., Chakrabartty A. Characterization of the interactions of Alzheimer β-amyloid peptides with phospholipid membranes. Eur. J. Biochem. 245:1997;355-363
38. Namba Y., Tomonaga M., Kawasaki H., Otomo E., Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:1991;163-166
39. Naslund J., Thyberg J., Tjernberg L.O., Wernstedt C., Karlstrom A.R., Bogdanovic N., Gandy S.E., Lannfelt L., Terenius L., Nordstedt C. Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron. 15:1995;219-228
40. Oda T., Wals P., Osterburg H.H., Johnson S.A., Pasinetti G.M., Morgan T.E., Rozovsky I., Stine W.B., Snyder S.W., Hozman T.F., Krafft G.A., Finch C.E. Clusterin (apoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress. Expt. Neurol. 136:1995;22-31
41. Pike C.J., Walencewicz A.J., Glabe C.G., Cotman C.W. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563:1991;311-314
42. Pike C.J., Burdick D., Walencewicz A.J., Glabe C.G., Cotman C.W. Neurodegeneration induced by β-amyloid peptides in vitro the role of peptide assembly state. J. Neurosci. 13:1993;1676-1687
43. Roher A.E., Palmer K.C., Surewicz E.C., Ball M.J., Greenberg B.D. Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue. J. Neurochem. 61:1993;1916-1926
44. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498
45. Simmons L.K., May P.C., Tomaselli K.J., Rydel R.E., Fuson K.S., Brigham E.F., Wright S., Lieberburg I., Becker G.W., Brems D.N. Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro. Mol. Pharmacol. 45:1993;373-379
46. Snow A.D., Nochlin D., Lara S., Wight T.N. Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease. Acta Neuropathol. 78:1989;113-123
47. Strittmater W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D. Apolipoprotein E high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl Acad. Sci. USA. 90:1993;1977-1981
48. Suzuki N., Cheung T.T., Cai X.D., Odaka A., Otvos L. Jr, Eckman C., Golde T.E., Younkin S.G. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (βAPP717) mutant. Science. 264:1994;1336-1340
49. Terzi E., Holzemann G., Seelig J. Self-association of β-amyloid peptide (1-40) in solution and binding to lipid membranes. J. Mol. Biol. 252:1995;633-642
50. Tjernberg L.O., Naslund J., Lindqvist F., Johansson J., Karlstrom A.R., Thyberg J., Terenius L., Nordstedt C. Arrest of β-amyloid fibril formation by a pentapeptide ligand. J. Biol. Chem. 271:1996;8545-8548
51. Tomiyama T., Shoji A., Kataoka K.-I., Suwa Y., Asano S., Kaneko H., Endo N. Inhibition of Amyloid β protein aggregation and neurotoxicity by rifampicin. J. Biol. Chem. 271:1996;6839-6844
52. Tyler J.M., Branton D. Rotary shadowing of extended molecules dried from glycerol. J. Ultrastruct. Res. 71:1980;95-102
53. Webster S., Rogers J. Relative efficacies of amyloid β peptide (Aβ) binding proteins in Aβ aggregation. J. Neurosci. Res. 46:1996;58-66
54. Webster S., O'Barr S., Rogers J. Enhanced aggregation and β-structure of amyloid β peptide after co-incubation with C1q. J. Neurosci. Res. 39:1994;448-456
55. Wisniewski T., Frangione B. Apolipoprotein E a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Letters. 135:1992;235-238
56. Wisniewski T., Castano E.M., Golabek A., Vogel T., Frangione B. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am. J. Pathol. 145:1994;1030-1034
57. Wood S.J., MacKenzie L., Maleeff B., Hurle M.R., Wetzel R. Selective inhibition of Aβ fibril formation. J. Biol. Chem. 271:1996;4086-4092