Review: Model peptides and the physicochemical approach to β-amyloids

Journal of Structural Biology

Volumn 130, Issue 2-3, 2000, Pages 153-173

  Lynn, David G ^a   Meredith, Stephen C ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Alzheimer's Disease; Amyloid; Block copolymers; Electron microscopy; Model peptides; Polyethylene glycol; Small angle neutron scattering; Small angle X ray scattering; Solid state NMR; amyloid; helices; sheets

Indexed keywords

AMYLOID BETA PROTEIN; PEPTIDE;

ALZHEIMER DISEASE; ELECTRON MICROSCOPY; HUMAN; MOLECULAR MODEL; NEUTRON SCATTERING; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RADIATION SCATTERING; REVIEW; X RAY DIFFRACTION;

EID: 0033855775     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2000.4287     Document Type: Review

References (181)

1. Solution structures of β peptide and its constituent fragments: Relation to amyloid deposition
2. Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease. Analysis of circular dichroism spectra
3. Propagating structure of Alzheimer's β-amyloid(10-35) is parallel β-sheet with residues in exact register
4. Two-dimensional structure of β-amyloid(10-35) fibrils
5. Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix
6. Characterization of the amyloid fibril as a cross-β protein
7. 2H nuclear magnetic resonance study
8. Nature disfavors sequences of alternating polar and non-polar amino acids: Implications for amyloidogenesis
9. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs
10. Cross-protein structures. I. Insulin fibrils
11. C-terminal PEG blocks the irreversible step in β-amyloid(10-35) fibrillogenesis
12. Self-assembly of Aβ(10-35)-PEG block copolymer fibrils
13. Rapid induction of Alzheimer Aβ amyloid formation by zinc
14. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily
15. Release of excess amyloid β-protein from a mutant amyloid β-protein precursor
16. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease β-protein
17. In situ characterization of β-amyloid in Alzheimer's diseased tissue by synchrotron Fourier transform infrared microspectroscopy
18. Empirical predictions of protein conformation
19. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
20. The parallel β helix of pectate lyase C: Something to sneeze at
21. Selective amyloid staining as a function of amyloid composition and structure. Histochemical analysis of the alkaline Congo red, standardized toluidine blue, and iodine methods
22. Determination of peptide amide configuration in a model amyloid fibril by solid-state NMR
23. β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
24. Transglutaminase facilitates the formation of polymers of the β-amyloid peptide
25. X-ray diffraction studies on amyloid filaments
26. Sickle cell hemoglobin polymerization
27. Two-dimensional crystallization of the chaperonin TF55 from the hyperthermophilic archaeon Sulfolobus solfataricus
28. New features of amyloid found after digestion with trypsin
29. Alzheimer's disease β-amyloid plaques displays first-order kinetics
30. Point substitution in the central hydrophobic cluster of a human β-amyloid congener disrupts peptide folding and abolishes plaque competence
31. A beta deposition inhibitor screen using synthetic amyloid
32. Impact of point mutations and amino-acid modifications on the structure and stability of peptides and proteins probed by FT-IR spectroscopy
33. The systemic amyloidoses: An overview
34. The interaction of β-amyloid protein fragment (12-28) with lipid environments
35. Morphology and antibody recognition of synthetic β-amyloid peptides
36. pH-Dependent structural transitions of Alzheimer amyloid peptides
37. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid β-protein
38. Conformation and fibrillogenesis of Alzheimer Aβ peptides with selected substitution of charged residues
39. Soluble amyloid Aβ-(1-40) exists as a stable dimer at low concentrations
40. Assembly and architecture of invertebrate cytoplasmic intermediate filaments reconcile features of vertebrate cytoplasmic and nuclear lamin-type intermediate filaments
41. Amyloidosis
42. Amyloid. VI. A comparison of two morphologic components of human amyloid deposits
43. The relation of the properties of Congo red-stained amyloid fibrils to the β-conformation
44. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
45. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
46. Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic x-ray diffraction pattern
47. Determination of local structure in solid nucleic acids using double quantum nuclear magnetic resonance spectroscopy
48. Dipolar recoupling NMR of biomolecular self-assemblies: Determining inter- and intrastrand distances in fibrilized Alzheimer's β-amyloid peptide
49. Nuclear-Magnetic-Resonance methods for measuring dipolar couplings in rotating solids
50. Dipolar correlation NMR-spectroscopy of a membrane-protein
51. Rotational resonance solid-state NMR elucidates a structural model of pancreatic amyloid
52. The analogy of amyloid and keratin as suggested by x-ray, amino acid, and ultrastructural analysis
53. Detection of weak heteronuclear dipolar recoupling by rotational-echo double-resonance nuclear magnetic resonance
54. Amyloid-β peptide is produced by cultured cells during normal metabolism
55. The presenilins in Alzheimer's disease proteolysis holds the key
56. Molecular determinants of amyloid deposition in Alzheimer's disease: Conformational studies of synthetic β-protein fragments
57. Atomic force microscopic imping of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-β protein
58. Ultrastructural study of a hitherto unknown disturbance of the synthesis of collagen precursor molecules in human cutis
59. Solid-state NMR studies of the prion protein H1 fragment
60. Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease
61. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease βA4 peptides
62. Cross-linking of β-amyloid protein precursor catalyzed by tissue transglutaminase
63. Kinetics and mechanism of deoxyhemoglobin S gelation: A new approach to understanding sickle cell disease
64. Special specimen preparation methods for image processing in transmission electron microscopy: A review
65. Zinc-induced Alzheimer's Aβ1-40 aggregation is mediated by conformational factors
66. Structural studies of soluble oligomers of the Alzheimer's β-amyloid peptide
67. Cross-linking of a synthetic partial-length (1-28) peptide of the Alzheimer β/A4 amyloid protein by transglutaminase
68. Structure of β-crystallite assemblies formed by Alzheimer β-amyloid protein analogues: Analysis by x-ray diffraction
69. Visualization of Aβ 42(43) and Aβ 40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ 42(43)
70. Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
71. Parallel β-domains: A new fold in protein structures
72. Secondary structures of proteins and peptides in amphiphilic environments
73. Amphiphilic secondary structure: Design of peptide hormones
74. Peptides with affinity for membranes
75. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
76. Mechanochemical mechanism for peptidyl free radical generation by amyloid fibrils
77. Amyloid fibril formation and protein misassembly: A structural quest for insights into amyloid and prion diseases
78. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-β conformation
79. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro
80. A left-hand β-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila
81. Fine structure of the dogfish egg case: A unique collagenous material
82. Amyloid diseases: Abnormal protein aggregation in neurodegeneration
83. Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains
84. Two-dimensional paracrystalline glycoprotein S-layers as a novel matrix for the immobilization of human IgG and their use as microparticles in immunoassays
85. Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide
86. Amyloid fibrils may be assembled from β-helical protofibrils
87. 1H NMR of Aβ Amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence
88. Theory and simulations of homonuclear spin pair systems in rotating solids
89. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
90. Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the Aβ peptide of Alzheimer's disease
91. On the nucleation and growth of amyloid β-protein fibrils: Detection of nuclei and quantitation of rate constants
92. Kinetic theory of fibrillogenesis of amyloid β-protein
93. X-ray diffraction studies of fibers and crystals of deoxygenated sickle cell hemoglobin
94. Reversible in vitro growth of Alzheimer disease β-amyloid plaques by deposition of labeled amyloid peptide
95. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
96. Reversible in vitro growth of Alzheimer disease β-amyloid plaques
97. Amyloid plaque core protein in Alzheimer disease and Down syndrome
98. Determination of internuclear distances and the orientation of functional groups by solid-state NMR: Rotational resonance study of the conformation of retinal in bacteriohodopsin
99. Ligand geometry of the ternary complex of 5-enolpyruvylshikimate-3-phosphate synthase from rotational-echo double-resonance NMR
100. Structural constraints on the ternary complex of 5-enolpyruvylshikimate-3-phosphate synthase from rotational-echo double-resonance NMR
101. High-resolution NMR of biological solids
102. Characterization of the interactions of Alzheimer β-amyloid peptides with phospholipid membranes
103. Distance measurements in nucleic acids using windowless dipolar recoupling solid state NMR
104. Pleomorphic mitochondrial and different filamentous inclusions in inflammatory myopathies associated with mtDNA deletions
105. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
106. First-order kinetic model of Alzheimer's β-amyloid fibril extension in vitro
107. Progress towards understanding β-sheet structure
108. Alzheimer's disease: A re-examination of the amyloid hypothesis
109. Molecular arrangement of troponin-tropomyosin in the thin filament
110. Configurations of polypeptide chains with favored orientations around single bonds: Two new pleated sheets
111. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity
112. Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures
113. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
114. Structure-activity analyses of β-amyloid peptides: Contributions of the β region to aggregation and neurotoxicity
115. Aggregation of secreted amyloid β-protein into sodium dodecyl sulfatestable oligomers in cell culture
116. Oligomerization of endogenous and synthetic amyloid β-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red
117. Differences between vascular and plaque core amyloid in Alzheimer's disease
118. Mutant genes in familial Alzheimer's disease and transgenic models
119. Prions
120. Degradation of amyloid β-protein by a metalloprotease secreted by microglia and other neural and non-neural cells
121. Identification of glutamine and lysine residues in Alzheimer amyloid βA4 peptide responsible for transglutaminase-catalysed homopolymerization and crosslinking to α2M receptor
122. Morphology and toxicity of Aβ-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
123. 13C NMR
124. Genetic dissection of Alzheimer disease, a heterogeneous disorder
125. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
126. Neuropathy associated with mitochondrial disorders
127. The toxicity of the Alzheimer's β-amyloid correlates with a distinct fiber morphology
128. Self-association of β-amyloid peptide (1-40) in solution and binding to lipid membranes
129. Brain transglutaminase: In vitro crosslinking of human neurofilament proteins into insoluble polymers
130. Alzheimer's disease: A central role for amyloid
131. Amyloid β-protein and the genetics of Alzheimer's disease
132. Translating cell biology into therapeutic advances in Alzheimer's disease
133. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
134. Light scattering analysis of fibril growth from the amino-terminal fragment β(1-28) of β-amyloid peptide
135. Structure of amyloid fibrils after negative staining and high-resolution electron microscopy
136. Production of the Alzheimer amyloid β protein by normal proteolytic processing
137. Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro
138. Purification and cloning of amyloid precursor protein β-secretase from human brain
139. Rotational resonance NMR determination of intra- and intermolecular distance constraints in dipalmitoylphosphatidylcholine bilayers
140. Surfactant properties of Alzheimer's Aβ peptides and the mechanism of amyloid aggregation
141. Structure determination of extracellular fragments of amyloid proteins involved in Alzheimer's disease and Dutch-type hereditary cerebral haemorrhage with amyloidosis
142. The α-helical to β-strand transition in the amino-terminal fragment of the amyloid β-peptide modulators amyloid formation
143. Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation
144. 13C nuclear-magnetic-resonance chemical-shifts
145. Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease
146. Long distance measurements of protein binding sites by rotational-echo double-resonance NMR
147. The structure of amyloid fibrils by electron microscopy and X-ray diffraction
148. Common core structure of amyloid fibrils by synchrotron X-ray diffraction
149. Solution structure of residues of the amyloid β-peptide
150. The use of electron tomography for structural analysis of disordered protein arrays
151. Structural and kinetic features of amyloid beta-protein fibrillogenesis
152. Reversible random coil-β-sheet transition of the Alzheimer β-amyloid fragment (25-35)
153. Alzheimer β-amyloid peptide25-35: Electrostatic interactions with phospholipid membranes
154. Self-association of β-amyloid peptide (1-40) in solution and binding to lipid membranes
155. A neutron-scattering study of poly(ethylene glycol) in electrolyte-solutions
156. The time-of-flight small-angle neutron diffractometer (SAD) at IPNS, Argonne National Laboratory
157. Arrest of β-amyloid fibril formation by a pentapeptide ligand
158. Controlling amyloid β-peptide fibril formation with proteasestable ligands
159. Kinetics of aggregation of synthetic beta-amyloid peptide
160. Deposition of monomeric, not oligomeric, Aβ mediates growth of Alzheimer's disease amyloid plaques in human brain preparations
161. Maintenance and inheritance of yeast prions
162. Measurement of nuclear magnetic dipole-dipole couplings in magic angle spinning NMR
163. Double-quantum filtering in magic-angle-spinning NMR spectroscopy - An approach to spectral simplification and molecular structure determination
164. Investigation of molecular structure in solids by two-dimensional NMR exchange spectroscopy with magic angle spinning
165. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
166. Characterization of β-amyloid peptide from human cerebrospinal fluid
167. Zur Cellulose-Frage
168. Amyloid β-protein fibrillogenesis. Detection of a protofibrillar intermediate
169. Determination of peptide conformations by two-dimensional magic angle spinning NMR exchange spectroscopy with rotor synchronization
170. Prions of yeast and heat-shock protein 104: 'Coprion' and cure
171. The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy
172. Prolines and amyloidogenicity in fragments of the Alzheimer's peptide β/A4
173. Amyloid β-protein (Aβ) associated with lipid molecules: Immunoreactivity distinct from that of soluble Aβ
174. New domain motif: The structure of pectate lyase C, a secreted plant virulence factor
175. Unusual structural features in the parallel beta-helix in pectate lyases
176. NMR studies of amyloid β-peptides: Proton assignments, secondary structure, and mechanism of an α-helix β-sheet conversion for a homologous, 28-residue, N-terminal fragment
177. Small-angle x-ray scattering from lipid bilayers is well described by modified Caille theory but not by paracrystalline theory
178. 2H-labeled Glu/Asp: Application to pKa measurements in Aβ amyloid peptides
179. Felix Hoppe-Seyler Lecture 1997. Protective antibody responses against viruses