Protective antibody responses against viruses

Biological Chemistry

Volumn 378, Issue 8, 1997, Pages 725-729

  Zinkernagel, Rolf M ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

Affinity maturation; Memory; Neutralisation; Receptor crosslinking; Self nonself

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; COLLAGEN; DNA; IMMUNOGLOBULIN M ANTIBODY; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIVIRAL ACTIVITY; B LYMPHOCYTE; CELL SURFACE; GENE MUTATION; GERM LINE; HELPER CELL; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; MEMORY CELL; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; T LYMPHOCYTE; VESICULAR STOMATITIS VIRUS; VIRUS ENVELOPE; ANIMAL; BIOSYNTHESIS; IMMUNOLOGY; MOUSE;

ANIMALS; ANTIBODIES, VIRAL; B-LYMPHOCYTES; HUMANS; IMMUNOLOGIC MEMORY; MICE;

EID: 0031202401     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Bachmann, M.F., and Zinkernagel, R.M. (1996). The influence of virus structure on antibody responses and virus serotype formation. Immunol. Today 12, 553-558.
2. Bachmann, M.F., Rohrer, U.H., Kündig, T.M., Bürki, K., Hengartner, H., and Zinkernagel, R.M. (1993). The influence of antigen organization on B cell responsiveness. Science 262, 1448-1451.
3. Bachmann, M.F., Kündig, T.M., Kalberer, C.P., Hengartner, H., and Zinkernagel, R.M. (1994a). How many specific B cells are needed to protect against a virus? J. Immunol. 152, 4235-4241.
4. Bachmann, M.F., Rohrer, U.H., Steinhoff, U., Bürki, K., Skuntz, S., Arnheiter, H., Hengartner, H., and Zinkernagel, R.M. (1994b). T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice. Eur. J. Immunol. 24, 2966-2973.
5. Bachmann, M.F., Hengartner, H., and Zinkernagel, R.M. (1995). T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction? Eur. J. Immunol. 25, 3445-3451.
6. Bachmann, M.F., Odermatt, B., Hengartner, H., and Zinkernagel, R.M. (1996). Induction of long-lived germinal centers associated with persisting antigen after viral infection. J. Exp. Med. 183, 2259-2269.
7. Bachmann, M.F., Kalinke, U., Althage, A., Freer, G., Burkhart, C., Roost, H.-P., Aguet, M., Hengartner, H., and Zinkernagel, R.M. (1997). Dominant role of antibody concentration versus avidity or 'on-rate' in anti-viral protection in vivo. Science 276, 2024-2027.
8. Berek, C., Griffiths, G.M., and Milstein, C. (1985). Molecular events during maturation of the immune response to oxazolone. Nature 316, 412-418.
9. Brambell, R.W.R. (1979). The transmission of immunity from mother to young. (Amsterdam: North Holland Publ. Corp.).
10. Bretscher, P., and Cohn, M. (1970). A theory of self-nonself discrimination. Science 169, 1042-1049.
11. Burnet, F.M. (1949). The Production of Antibodies (Melbourne: Macmillan Co).
12. Charan, S., and Zinkernagel, R.M. (1986). Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus. J. Immunol. 136, 3057-3061.
13. Coico, R.F., Bhogal, B.S., and Thorbecke, G.J. (1983). Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin. J. Immunol. 131, 2254-2257.
14. Eisen, H.N., and Siskind, G.W. (1964). Variations in affinities of antibodies during the immune response. Biochemistry 3, 996-1008.
15. Flamand, A., Raux, H., Gaudin, Y., and Ruigrok, R.W.H. (1993). Mechanisms of Rabies virus neutralization. Virology 194, 302-313.
16. Gray, D. (1993). Immunological memory. Annu. Rev. Immunol. 11, 49-77.
17. Heidelberger, M. (1956). Lectures in Immunochemistry (New York: Academic Press).
18. Kalinke, U., Bucher, E.M., Oxenius, A., Ernst, B., Roost, H.-P., Geley, S., Kofler, R., Zinkernagel, R.M., and Hengartner, H. (1996a). The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus (VSV). Immunity 5, 639-652.
19. Kalinke, U., Krebber, A., Krebber, C., Bucher, E., Plückthun, A., Zinkernagel, R.M., and Hengartner, H. (1996b). Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus (VSV) protect against lethal infection. Eur. J. Immunol. 26, 2801-2806.
20. Landsteiner, K. (1945). The Specificity of Serological Reactions (Boston: Harvard University Press).
21. Lehmann-Grube, F. (1971). Lymphocytic choriomeningitis virus. Virol. Monogr. 10, 1-173.
22. Rajewsky, K. (1989). Evolutionary and somatic immunological memory. In: Progress in Immunology. F. Melchers, ed. (Berlin: Springer-Verlag), pp. 397-403.
23. Roost, H.-P., Bachmann, M.F., Haag, A., Kalinke, U., Pliska, V., Hengartner, H., and Zinkernagel, R.M. (1995). Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity [see comments]. Proc. Natl. Acad. Sci. USA 92, 1257-1261.
24. Rose, N.R., and Mackay, I.R. (1992). The autoimmune diseases II (London: Academic Press, Ltd.).
25. k. J. Immunol. 126, 446-451.
26. Schwartz, R.H. (1990). A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356.
27. Steinhoff, U., Burkhart, C., Arnheiter, H., Hengartner, H., and Zinkernagel, R. (1994). Virus or a hapten-carrier complex can activate autoreactive B cells by providing linked T help. Eur. J. Immunol. 24, 773-776.
28. Theofilopoulos, A.N., and Dixon, F.J. (1979). The biology and detection of immune complexes. Adv. Immunol. 28, 89-189.
29. Wagner, R.R. (1987). The Rhabdoviruses (New York: Plenum Press).
30. Zinkernagel, R.M., Cooper, S., Chambers, J., Lazzarini, R.A., Hengartner, H., and Arnheiter, H. (1990). Virus-induced autoantibody response to a transgenic viral antigen. Nature 344, 68-71.