Inhibition of cyclin-dependent kinase activity and induction of apoptosis by Preussin in human tumor cells

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 10, 2000, Pages 2794-2801

  Achenbach, T V ^a   Slater, E P ^a   Brummerhop, H ^a   Bach, T ^a   Muller, R ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CASPASE; CYCLIN A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; CYTOCHROME C; PREUSSIN; PROTEIN BCL 2; PROTEIN P27; TRANSCRIPTION FACTOR E2F;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL CYCLE S PHASE; CELL LEVEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANISOMYCIN; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CYCLIN-DEPENDENT KINASES; CYTOCHROME C; CYTOSOL; DNA; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; GENES, BCL-2; HUMAN; IMMUNOBLOTTING; METHIONINE; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0033797835     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.10.2794-2801.2000     Document Type: Article

References (47)

1. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts
2. Ungewohnliche faciale Diastereoselektivitat in der Paterno-Buchi-Reaktion eines chiralen Dihydropyrrols - Eine kurze Totalsynthese von (+)-Preussin
3. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
4. Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells
5. Colorimetric growth assay for epidermal cell cultures by their crystal violet binding capacity
6. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
7. Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells
8. Biochemical pathways of caspase activation during apoptosis
9. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
10. p53 oncogene mutations in three human prostate cancer cell lines
11. Antitumoral activity of flavone L 86-8275
12. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
13. Induction of apoptosis in fibroblasts by c-myc protein
14. CDK inhibition and cancer therapy
15. ATP-site directed inhibitors of cyclin-dependent kinases
16. Exploiting chemical libraries, structure and genomics in the search for kinase inhibitors
17. Tumorigenicity of ten karyotypically distinct cell types present in the human melanoma cell line MeWo-A
18. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
19. Traps to catch unwary oncogenes
20. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
21. The relative and absolute stereochemistry of the antifungal agent preussin
22. Identification of preussin as a selective inhibitor for cell growth of the fission yeast ts mutants defective in Cdc2-regulatory genes
23. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
24. Cancer therapy meets p53
25. DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis
26. BCL-2 gene family and the regulation of programmed cell death
27. Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275
28. Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes
29. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
30. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
31. Induction of DNA synthesis and apoptosis am separable functions of E2F-1
32. Mechanisms of Bcl-2 family protein function and dysfunction in health and disease
33. Mechanisms of apoptosis avoidance in cancer
34. Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target
35. Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells
36. Stereoselective synthesis and biological evaluation of anisomycin and 2-substituted analogues
37. L-657,398, a novel antifungal agent: Fermentation, isolation, structural elucidation and biological properties
38. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
39. Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines
40. 1-phase progression
41. Bcl-2 expression prevents activation of the ICE protease cascade
42. Caspases: Enemies within
43. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells
44. Clinical trials referral resource. Clinical trials of flavopiridol
45. Induction of apoptosis in small-cell lung cancer cells by an antisanse oligodeoxynucleotide targeting the Bcl-2 coding sequence
46. Cell-cycle regulation of gene expression by transcriptional repression