The anorexia of aging

Nutrition

Volumn 16, Issue 10, 2000, Pages 983-995

  MacIntosh, Caroline ^a   Morley, John E ^b   Chapman, Ian M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; CHOLECYSTOKININ; CORTICOSTEROID; CYTOKINE; GLUCAGON LIKE PEPTIDE 1; GROWTH HORMONE; INSULIN; LEPTIN; NEUROPEPTIDE Y; NITRIC OXIDE; OPIATE; PEPTIDE YY; TESTOSTERONE;

AGED; AGING; ALZHEIMER DISEASE; ANOREXIA; APPETITE; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFERENCE PAPER; DEMENTIA; DEPRESSION; DIET; DIET SUPPLEMENTATION; DRUG USE; DYSPEPSIA; DYSPHAGIA; ENTERIC FEEDING; FOOD INTAKE; GASTROINTESTINAL DISEASE; HUMAN; HYPERMETABOLISM; INFECTION; MALABSORPTION; MORTALITY; NUTRITIONAL STATUS; ODOR; PARKINSON DISEASE; POVERTY; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; PSYCHOLOGICAL ASPECT; SATIETY; SEX DIFFERENCE; SOCIOECONOMICS; TASTE;

AGED; AGED, 80 AND OVER; AGING; ANOREXIA; APPETITE REGULATION; ENERGY INTAKE; ENERGY METABOLISM; GASTROINTESTINAL SYSTEM; HUMAN; NEUROTRANSMITTERS; NUTRITION DISORDERS; NUTRITIONAL STATUS; SMELL; TASTE; WEIGHT LOSS;

EID: 0033780514     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(00)00405-6     Document Type: Conference Paper

References (263)

1. The epidemiology of aging
2. Causes of weight loss in a community nursing home
3. Anorexia in the elderly
4. Total energy intake of the US population; the third National Health and Nutrition Examination Survey, 1988-1991
5. Continuing trends in men; The Baltimore Longitudinal Study of Aging (1961-1987)
6. Intake of energy, nutrients and food items in a ten-year cohort comparison and in a six-year longitudinal perspective; a population study of 70- and 76-year-old Swedish people
7. The New Mexico Aging Process Study
8. Anorexia of aging; physiologic and pathologic
9. Age-related changes in spontaneous food intake and hunger in humans
10. Calorie and nutrient intakes of elderly and young subjects measured under identical conditions
11. Evidence for the anorexia of aging; gastrointestinal transit and hunger in healthy elderly vs. young adults
12. Control of food intake in older men
13. Age-related impairments in the regulation of food intake
14. Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age
15. Epidemiology of sarcopenia among the elderly in New Mexico
16. Prevalence of obesity in Sweden; cross-sectional study of a representative adult population
17. Aging in women-the four-compartment model of body composition
18. Effect of aging on body fat
19. Body composition and aging
20. Distributions of serial changes in stature and weight in a healthy elderly population
21. Modification of the relationship between the Quetelet index and mortality by weight-loss history among older women
22. Sarcopenia and age-related changes in body composition and functional capacity
23. Involuntary weight loss in older outpatients; incidence and clinical significance
24. Childhood, youth and old age
25. The relationship of loneliness, social isolation, and physical health to dietary adequacy of independently living elderly
26. Factors associated with low body mass index and weight loss in nursing home residents
27. Failure to thrive in the elderly; exploration of the concept and delineation of psychiatric components
28. Depression in older people; a study
29. Increased rate of psychosis and psychomotor change in depression with age
30. Nutritional status and dietary intake in institutionalized patients with Alzheimer's disease and multiinfarct dementia
31. Prevalence and causes of undernutrition in medical outpatients
32. Dietary intakes and biochemical indicators of nutritional status in an elderly institutionalized population
33. Effect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men
34. Changes in gastrointestinal function attibuted to aging
35. Rheumatoid cachexia; cytokine driven hypermetabolism and loss of lean body mass in chronic inflammation
36. Important drug-nutrient interactions in the elderly
37. Nutritional assessment of the elderly in the ambulatory care setting
38. Prevalence of protein energy malnutrition in a large population of elderly people at home
39. Nutritional status on admission to a general surgical ward in a Sydney hospital
40. Nutritional status and postoperative complications in an Australian hospital
41. Nutritional status in hospital inpatients; implications for nutritional support services
42. Famine in the midst if plenty; nutritional status of the frail elderly
43. Undernutrition in older hospitalized patients
44. Correlation of pressure sores and nutritional status
45. Nutritional status of nursing home patients
46. Anthropometric measurements as predictors of mortality in a community population aged 70 years and over
47. Body mass index and mortality in the elderly
48. Nutritional issues in nursing home care
49. Outcome of protein-energy malnutrition in elderly medical patients
50. Involuntary weight loss; diagnostic and prognostic significance
51. Unintentional weight loss. A retrospective analysis of 154 cases
52. Protein-energy undernutrition and the risk of mortality within 1 y of hospital discharge in a select population of geriatric rehabilitation patients
53. Prevalence and clinical outcome assoiated with pre-existing malnutrition in acute renal failure; a prospective study
54. Effect of malnutrition after acute stroke on clinical outcome
55. Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men
56. Reduced thirst after water deprivation in healthy elderly men
57. Neuropeptide regulation of appetite and weight
58. Opioid modulation of appetite
59. Evidence that neuropeptide Y is a physiological signal for normal food intake
60. Effect of galanin on food intake in rats; involvement of lateral and ventromedial hypothalamic sites
61. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y
62. The stomach, cholecystokinin, and satiety
63. Evidence that nitric oxide stimulates feeding in the marsupial Sminthopsis crassicaudata
64. The role of the gut in regulating food intake in man
65. Regulation of nutrient supply; the brain and appetite control
66. Age-associated changes in taste and odor sensation, perception, and preference
67. Taste acuity and aging
68. Human taste bud density across adult age groups
69. Taste and sensitivity and aging; high incidence of decline revealed by repeated theshold measures
70. Aging is associated with increased Weber ratios for caffeine, but not for sucrose
71. Taste preferences and food intake
72. Smell identification ability; changes with age
73. Olfactory dysfunction and related nutritional risk in free-living, elderly women
74. Variation in nutrient intake with dental status, age and odour perception
75. Characterizing consumption patterns by food frequency methods; core foods and variety of foods in diets of older Americans
76. Effects of age on sensory-specific satiety
77. Variety in a meal enhances food intake in man
78. Food cravings in young and elderly adults
79. Endorphins and food intake; kappa opioid receptor agonists and hyperphagia
80. The effects of aging on opioid modulation of feeding in rats
81. Opioids and consumatory behaviour
82. Effect of intrahypothalamic injections of D-Ala-D-Leu enkephalin on feeding and temperature in rats
83. Naloxone's anorectic effect is dependent upon the relative palatability of food
84. Naloxone reduces the food intake of normal human volunteers
85. Naloxone reduces food intake in humans
86. Naloxone decreases food intake in obese humans
87. Behavioural effects of naloxone on neuropeptide Y-induced feeding
88. Role of the opioid system in the hypodipsia associated with aging
89. Age-related changes in central nervous system enkephalins and substance P
90. Interaction of age and thyroid hormone status on beta-endorphin content in rat corpus stratium and hypothalamus
91. Immunoreactive B-endorphin in the plasma, pituitary, and hypothalamus of young and old male rats
92. The effect of haloperidol on met-enkephalin, B-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the stratium of rats during aging
93. Age-related changes in central nervous system beta-endorphin and ACTH
94. Changes of B-endorphin and met-enkephalin content in the hypothalamus-pituitary axia induced by aging
95. Age-related and diurnal changes in met5-enk-arg6-phe7 and met5-enkephalin contents of the pituitary and rat brain structures
96. Alterations in plasma and cerebrospinal fluid levels of neuropeptides in idiopathic senile anorexia
97. The influence of opiate agonists on day-night feeding rhythms in young and old mice
98. Effect of aging on fluid ingestion in mice
99. Interactions among aging, gender, and gonadectomy effects upon naloxone hypophagia in rats
100. Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase; further evidence for a role of nitric oxide in feeding
101. Effects of intracerebroventricular leptin administration on food intake, body weight gain and diencephalic nitric oxide synthase activity in the mouse
102. Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats
103. Nitric oxide controls feeding behavior in the chicken
104. Competitive antagonism of nitric oxide synthetase causes weight loss in mice
105. Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice
106. Aging modulates nitric oxide synthesis and cGMP levels in hippocampus and cerebellum. Effects of amyloid beta peptide
107. Changes in NMDA receptor/nitric oxide signaling pathway in the brain with aging
108. Inhibition of feeding by a nitric oxide synthase inhibitor; effects of aging
109. Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats
110. Increase of neuronal nitric oxide synthase in rat skeletal muscle during ageing
111. Role of nitric oxide-related mechanisms in renal function in ageing rats
112. Characterization and regional distribution of nitric oxide synthase in the human brain during normal ageing
113. Effect of nitric oxide synthase inhibitors on short-term appetite and food intake in humans
114. Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis
115. Response of neuropeptide Y-deficient mice to feeding effectors
116. Endocrine function of neuropeptide Y knockout mice
117. Life without neuropeptide Y
118. Insulin in the brain; a hormonal regulator of energy balance
119. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y
120. Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats
121. Age-related changes in cortico-releasing factor, somatostatin, neuropeptide Y, methionine enkephalin and beta-endorphin in specific rat brain areas
122. Effects of lifelong moderate caloric restriction on levels of neuropeptide Y, proopiomelanocortin, and galanin mRNA
123. Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats
124. Neuropeptide Y increases food intake in mice
125. Modulation of vagal efferent fibre discharge by mechanoreceptors in the stomach, duodenum and colon of the ferret
126. Gastric distension and gastric capacity in relation to food intake in humans
127. Relation between postprandial satiation and antral area in normal subjects
128. Fall in the number of myenteric neurons in aging guinea pigs
129. Nerve cell loss in the myenteric plexus of the human esophagus in relation to age; a preliminary investigation
130. Influence of age on cerebral potentials evoked by oesophageal balloon distension in humans
131. Effect of aging on anorectal function
132. Influence of age on rectal tone and sensitivity to distension in healthy subjects
133. Evidence for diminished visceral pain with aging; studies using graded intraoesophageal balloon distension
134. Gastric emptying and small-bowel transit rate in the elderly
135. Appetite Regulation by gut peptides
136. Gastric emptying in diabetes; an overview
137. Changes in gastric emptying rates with age
138. Effects of gender, age, and body mass index on gastrointestinal transit times
139. Effect of ageing on the gastro-intestinal transit of a lactulose-supplemented mixed solid-liquid meal in humans
140. The patterns of motility are maintained in the human small intestine throughout the process of aging
141. Effect of age on human gastric and small bowel motility
142. Effect of ileal and intravenous infusions of fat emulsions on feeding and satiety in human volunteers
143. Appetite regulation by carbohydrate; role of blood glucose and gastrointestinal hormones
144. Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion
145. Inhibition of gastric emptying by sodium oleate depends on length of intestine exposed to nutrient
146. Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient
147. Role of cholecystokinin in the control of food intake
148. Appetite regulation; the role of peptides and hormones
149. Cholecystokinin suppresses food intake by inhibiting gastric emptying
150. Satiety effects of a physiological dose of cholecystokinin in humans
151. C-terminal octapeptide of cholecystokinin decreases food intake in man
152. Effects of cholecystokinin-octapeptide (CCK-8) on food intake and gastric emptying in man
153. Cholecystokinin octapeptide decreases intake of solid food in man
154. C-terminal octapeptide of cholecystokinin decreases food intake in obese men
155. Peptide cholecystokinin antagonist increases food intake in rats
156. Effects of the CCK receptor antagonist MK-329 on food intake in pigs
157. Voluntary intake and gastric emptying in pigs; effects of fat and a CCK inhibitor
158. Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans
159. Effect of a low-dose of intraduodenal fat on satiety in humans; studies using the type A cholecystokinin receptor antagonist loxiglumide
160. Cholecystokinin octapeptide stimulates phasic and tonic pyloric motility in healthy humans
161. Gastric and nongastric mechanisms for satiety action of cholecystokinin
162. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid
163. Development and age-related changes in pancreatic cholecystokinin receptors and duodenal cholecystokinin in guinea pigs
164. Ageing and endocrine cells of human duodenum
165. Effect of aging on gallbladder contraction and release of cholecystokinin 33 in humans
166. Effect of aging on plasma cholecystokinin secretion and gallbladder emptying
167. The effects of age on plasma cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) concentrations and their relation to appetite and pyloric motility
168. Postprandial cholecystokinin secretion in elderly with protein-energy undernutrition
169. Effects of cholecystokinin octapeptide (CCK-8) on food intake in adult and aged rats under different feeding conditions
170. Effect of gastrointestinal peptides on ingestion in old and young mice
171. Does cholecystokinin play a role in the anorexia of ageing?
172. Gastric emptying and release of incretin hormones after glucose ingestion in humans
173. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
174. Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake
175. Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men
176. A role for glucagon-like peptide-1 in the central regulation of feeding
177. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
178. Glucagon-like peptide 1 is a physiologic regulator of food intake in humans
179. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
180. The ageing entero-insular axis
181. Independent release of peptide YY (PYY) into the circulation and ileal lumen of the awake dog
182. Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man
183. Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviours
184. Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers
185. Effects of peptide YY and neuropeptide Y on gastric emptying in man
186. Neuropeptide Y- and peptide YY-containing colonic cells increase with ageing in male rats
187. Islet amyloid polypeptide-a novel controversy in diabetes research
188. Amylin concentrations and glucose control
189. Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin
190. Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM
191. Reduction of postprandial hyperglycemia in subjects with IDDM by intravenous infusion of AC137, a human amylin analogue
192. Anorectic effects of amylin in rats over the life span
193. Modulation of food intake by peripherally administered amylin
194. Synergy between amylin and cholecystokinin for inhibition of food intake in mice
195. Pramlintide, a synthetic analog of human amylin, improves the metabolic profile of patients with type 2 diabetes using insulin. The Pramlintide in Type 2 Diabetes Group
196. Age-related changes in amylin secretion
197. Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load
198. Human aging is associated with parallel reductions in insulin and amylin release
199. Age-related changes in postprandial plasma glucose, insulin, and free fatty acid concentrations in nondiabetic individuals
200. Body fatness and waist circumference are independent predictors of the age-associated increase in fasting insulin levels in healthy men and women
201. Suppression of food intake by intravenous nutrients and insulin in the baboon
202. Reduction of food intake and body weight by chronic intraventricular insulin infusion
203. Effect of intravenous glucose and euglycemic insulin infusions on short-term appetite and food intake
204. Weight-reducing effects of the plasma protein encoded by the obese gene
205. Effects of the obese gene product on body weight regulation in ob/ob mice
206. Leptin treatment rescues the sterility of genetically obese ob/ob males
207. Congenital leptin deficiency is associated with severe early-onset obesity in humans
208. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
209. Recombinant leptin for weight loss in obese and lean adults; a randomized, controlled, dose-escalation trial
210. Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats; association of serum leptin levels with peripheral adiposity
211. Effects of nutritional status and aging on leptin gene expression in mice; importance of glucose
212. Leptin mRNA expression and serum leptin concentrations as influenced by age, weight, and estradiol in pigs
213. Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat
214. Serum leptin concentration in women; effect of age, obesity, and estrogen administration
215. The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels; its relationships with body fat, visceral adiposity, and age in women
216. Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression
217. Inverse correlation between serum testosterone and leptin in men
218. Effects of anabolic-androgenic steroid use or gonadal testosterone suppression on serum leptin concentration in men
219. Hormonal and physiological correlates of energy expenditure and substrate oxidation in middle-aged, premenopausal women
220. Disruption of the relationship between fat content and leptin levels with aging in humans
221. Geriatric cachexia; the role of cytokines
222. Anticachectin/tumor necrosis factor-alpha antibodies attenuate development of cachexia in tumor models
223. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia
224. Increased urine interleukin-1 levels in aging
225. Enhanced generation of interleukins 1 beta and 6 may contribute to the cachexia of chronic disease
226. Monocyte cytokine production in an elderly population; effect of age and inflammation
227. Interleukin-6 and aging; blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction
228. The association of plasma IL-6 levels with functional disability in community-dwelling elderly
229. Assessment of protein energy malnutrition in older persons, part I; history, examination, body composition, and screening tools
230. Assessment of protein energy malnutrition in older persons, part II; laboratory evaluation
231. Effect of flavour-enhancement of foods for the elderly on nutritional status; food intake, biochemical indices, and anthropometric measures
232. Dietary supplementation in elderly patients with fractured neck of the femur
233. Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur
234. Nutritional status of elderly patients during recovery from chest infection and the role of nutritional supplementation assessed by a prospective randomized single-blind trial
235. Exercise training and nutritional supplementation for physical frailty in very elderly people
236. Randomized clinical trial of nutritional supplementation shows little effect on functional status among free-living frail elderly
237. Nutritional supplementation in elderly medical in-patients; a double-blind placebo-controlled trial
238. Vitamin D and calcium to prevent hip fracture in elerly women
239. Effect of vitamin and trace element supplementation on immune system and infection in elderly subjects
240. Nutritional support in hospitalized patients with alcoholic liver disease with enteral nutrition
241. Nutritional deficiencies in long term care, part II; management of protein energy malnutrition and dehydration
242. Megestrol acetate; a medical nutrition therapy tool to effect positive weight outcomes in the elderly
243. Depression
244. Growth hormone, exercise and ageing; the future of therapy of the frail elderly
245. Increased mortality associated with growth hormone treatment in ill adults
246. Short-term oxandrolone administration stimulates net muscle protein synthesis in young men
247. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
248. Effects of nandrolone decanoate therapy in borderline hypogonadal men with HIV-associated weight loss
249. Male hormone replacement therapy including 'andropause
250. Effect of testosterone treatment on bone mineral density in men over 65 years of age
251. Predictors of skeletal muscle mass in elderly men and women
252. Androgen deficiency in aging men
253. The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection
254. Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury
255. Anorexia in older persons; epidemiology and optimal treatment
256. Anorexia and aging; pathophysiology