Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression

American Journal of Physiology - Endocrinology and Metabolism

Volumn 275, Issue 3 38-3, 1998, Pages

  Li, Hua ^b   Matheny, Michael ^b   Tümer, Nihal ^b   Scarpace, Philip J ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

F 344xBN rats; Food intake; Inguinal, retroperitoneal, or epididymal white adipose tissue; Lee index; Leptin mRNA; Obesity gene; Serum

Indexed keywords

LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; RNA;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIET RESTRICTION; DOT HYBRIDIZATION; GENE; GENE EXPRESSION; HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; WHITE ADIPOSE TISSUE;

EID: 0031668175     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.275.3.e405     Document Type: Article

References (32)

1. Akabayashi, A., N. Levin, X. Paez, J. T. Alexander, and S. F. Leibowitz. Hypothalamic neuropeptide Y and its gene expression: relation to light/dark cycle and circulating corticosterone. Mol. Cell. Neurosci. 5: 210-218, 1994.
2. Bernardis, L. L., R. Luboshitsky, L. L. Bellinger, and G. McEwen. Nutritional studies in the weaning rat with normophagic hypothalamic obesity. J. Nutr. 112: 1441-1455, 1982.
3. Bernardis, L. L., and B. D. Patterson. Correlation between "Lee index" and carcass fat content in weanling and adult female rats with hypothalamic lesions. J. Endocrinol. 40: 527-528, 1968.
4. Brozek, J. Changes in body composition in man during maturity and their nutritional implications. Federation Proc. 11: 784-793, 1952.
5. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
6. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
7. Clark, J. T., P. S. Kalra, W. R. Crowley, and S. P. Kalra. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427-429, 1984.
8. Epstein, F. H., and M. Higgins. Epidemiology of obesity. In: Obesity, edited by P. Bjorntorp and B. N. Brodoff. Philadelphia, PA: Lippincott, 1992, p. 330-342.
9. Gruenewald, D. A., B. T. Marck, and A. M. Matsumoto. Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats. Endocrinology 137: 4460-4467, 1996.
10. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
11. Heusner, A. Body size and energy metabolism. Annu. Rev. Nutr. 5: 267-293, 1985.
12. Lee, M. O. Determination of the surface area of the white rat with its application to the expression of metabolic results. Am. J. Physiol. 89: 24-31, 1929.
13. Levine, A. S., and J. E. Morley. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5: 1025-1029, 1984.
14. Li, H., M. Matheny, M. Nicolson, N. Tümer, and P. J. Scarpace. Leptin gene expression increases with age independent of increasing adiposity in rats. Diabetes 46: 2035-2039, 1997.
15. 3-Adrenergic-mediated suppression of leptin gene expression in rats. Am. J. Physiol. 272 (Endocrinol. Metab. 35): B1031-E1036, 1997.
16. Malina, R. M. Quantification of fat, muscle and bone in man. Clin. Orthop. 65: 9-38, 1969.
17. Meier, C. A. Advances in the understanding of the molecular basis of obesity. Eur. J. Endocrinol. 133: 761-763, 1995.
18. O'Shea, R. D., and A. L. Gundlach. Preproneuropeptide Y messenger ribonuceic acid in the hypothalamic arcuate nuceus of the rat is increased by food deprivation or dehydration. J. Neuroendocrinol. 3: 11-14, 1991.
19. Pelleymounter, M., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
20. Richardson, G. S. Circadian rhythms and aging. In: Handbook of the Biology of Aging, edited by E. Schneider and G. Rowe. New York: Academic, 1990, p. 275-305.
21. Saladin, R., P. De Vos, M. Guerre-Millo, A. Leturque, J. Girard, B. Staels, and J. Auwerx. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529, 1995.
22. Scarpace, P. J., and M. Matheny. Leptin increases uncoupling protein expression and energy expenditure. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E226-E230, 1997.
23. Scarpace, P. J., M. Matheny, S. Borst, and N. Tümer. Thermoregulation with age: roll of thermogenesis and uncoupling protein expression in brown adipose tissue. Proc. Soc. Exp. Biol. Med. 205: 154-161, 1994.
24. Schwatz, M. W., D. G. Baskin, T. R. Bukowski, J. L. Kuijper, D. Foster, G. Lasser, D. E. Prunkard, D. Porte, S. C. Woods, R. J. Seeley, and D. S. Weigle. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535, 1996.
25. Sprott, R. L., and S. N. Austad. Animals models for aging research. In: Handbook of the Biology of Aging, edited by E. L. Schneider and J. W. Rowe. San Diego: Academic, 1996, p. 3-23.
26. Stanley, B. G., and S. F. Leibowitz. Neuropeptide Y injected into hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Proc. Natl. Acad. Sci. USA 82: 3940-3943, 1984.
27. Stephens, T. W., M. Basinski, P. K. Bristow, J. M. Bue-Valleskey, S. G. Burgett, L. Craft, J. Hale, J. Hoffmann, H. M. Hsiung, A. Kriauciunas, W. MacKellar, P. R. Rosteck, Jr., B. Schoner, D. Smith, F. C. Tinsley, X.-Y. Zhang, and H. Heiman. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532, 1995.
28. Taylor, B. A., and S. J. Phillips. Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics 34: 389-398, 1996.
29. Trayhurn, P., J. S. Duncan, and D. V. Rayner. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem. J. 311: 729-733, 1995.
30. Trayhurn, P., M. E. A. Thomas, J. S. Duncan, and D. V. Rayner. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett. 368: 488-490, 1995.
31. White, J. D., and M. Kershaw. Increased hypothalamic neuropeptide Y expression following food deprivation. Mol. Cell. Neurosci. 1: 41-48, 1990.
32. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.