Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM

Diabetologia

Volumn 40, Issue 1, 1997, Pages 82-88

  Kong, M F ^a,d   King, P ^a   Macdonald, I A ^b   Stubbs, T A ^b   Perkins, A C ^a   Blackshaw, P E ^a   Moyses, C ^c   Tattersall, R B ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c Amylin Europe Ltd   (United Kingdom)

^d QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

amylin; gastric emptying; insulin dependent diabetes mellitus; postprandial hyperglycaemia; pramlintide

Indexed keywords

INSULIN; PRAMLINTIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH EMPTYING; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031034124     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050646     Document Type: Article

References (28)

1. Rink TJ, Beaumont K, Koda J, Young A (1993) Structure and biology of amylin. Trends Pharmacol Sci 14: 113-118
2. Thompson RG, Gottlieb AB, Peterson J (1995) The human amylin analogue AC137 reduces mean 24 hour glucose in type 1 diabetes. Diabetologia 38 [Suppl 1]: A44 (Abstract)
3. Brown K, Menius A, Sandefer E, Edwards J, James M (1994) The effects of amylin on changes in plasma glucose and gastric emptying following an oral glucose load in conscious dogs. Diabetes 43 [Suppl 1]: 172 A (Abstract)
4. Young AA, Gedulin B, Vine W, Percy A, Rink TJ (1995) Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin. Diabetologia 38: 642-648
5. Kolterman OG, Gottlieb A, Moyses C, Colburn W (1995) Reduction of postprandial hyperglycaemia in subjects with IDDM by intravenous infusion of AC137, a human amylin analogue. Diabetes Care 18: 1179-1182
6. Frier M, Perkins AC (1994) Radiopharmaceuticals and the gastrointestinal tract - review article. Eur J Nucl Med 21: 1234-1242
7. Hardy JG, Perkins AC (1985) Validity of the geometric mean correction in the quantification of whole bowel transit. Nucl Med Commun 6: 217-224
8. Qamar MI, Read AE, Skidmore R, Evans JM, Wells PNT (1986) Transcutaneous Doppler ultrasound measurement of superior mesenteric artery blood flow in man. Gut 27: 100-105
9. Laker MF, Mount JN (1980) Mannitol estimation in biological fluids by gas-liquid chromatography of trimethylsilyl derivatives. Clin Chem 26: 441-443
10. Laker MF (1979) Estimation of disaccharides in plasma and urine by gas-liquid chromatography. J Chromatogr 163: 9-18
11. MacGregor I, Gueller R, Watts H, Meyer J (1976) The effects of acute hyperglycaemia on gastric emptying in man. Gastroenterology 70: 190-196
12. Fraser R, Horowitz M, Maddox A, Harding P, Chatterton B, Dent J (1990) Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 33: 675-680
13. Horowitz M, Harding P, Maddox AF et al. (1989) Gastric and oesophageal emptying in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 32: 151-159
14. Eliasson B, Björnsson E, Urbanavicius V et al. (1995) Hyperinsulinaemia impairs gastrointestinal motility and slows carbohydrate absorption. Diabetologia 38: 79-85
15. Laker MF, Bull HJ, Menzies IS (1982) Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man. Eur J Clin Invest 12: 485-491
16. Fordtran JS, Clodi PH, Soergel KH, Ingelfinger FJ (1962) Sugar absorption tests, with special reference to 3-O-methyl-D-glucose and D-xylose. Ann Intern Med 57: 883-891
17. Qamar MI, Read AE, Mountford R (1986) Increased superior mesenteric blood flow after glucose but not after lactose ingestion. Q J Med 60: 893-896
18. Collins PJ, Houghton LA, Read NW et al. (1991) Role of the proximal and distal stomach in mixed solid and liquid meal emptying. Gut 32: 615-619
19. Kolterman OG, Schwartz S, Corder C et al. (1996) Effect of 14 days' subcutaneous administration of the human amylin analogue, pramlintide (AC137), on an intravenous insulin challenge and response to a standard liquid meal in patients with IDDM. Diabetologia 39: 492-499
20. Jenkins DJA, Wolever TMS, Ocana AM (1990) Metabolic effects of reducing rate of glucose ingestion by single bolus versus continuous sipping. Diabetes 39: 775-781
21. Bennet WM, Smith DM, Bloom SR (1994) Islet amyloid polypeptide: does it play a pathophysiological role in the development of diabetes? Diabet Med 11: 825-829
22. Koda JE, Fineman M, Rink TJ, Dailey GE, Muchmore DB, Linarelli LG (1992) Amylin concentrations and glucose control. Lancet 339: 1179-1180
23. Nowak TV, Roza AM, Weisbruch JP, Brosnan MR (1994) Accelerated gastric emptying in diabetic rodents: effect of insulin treatment and pancreas transplantation. J Lab Clin Med 123(1): 110-116
24. Nowak TV, Johnson CP, Kalbfleisch JH et al. (1995) Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. Gut 37: 23-29
25. Keshavarzian A, Iber FL, Vaeth J (1987) Gastric emptying in patients with insulin requiring diabetes mellitus. Am J Gastroenterol; 82: 29-35
26. Pehling G, Tessari P, Gerich JE, Haymond MW, Service FJ, Rizza RA (1984) Abnormal meal carbohydrate disposition in insulin-dependent diabetes. J Clin Invest 74: 985-991
27. Horowitz M, Maddox AF, Wishart JM, Harding PE, Chatterton BE, Shearman DJC (1991) Relationships between oesophageal transit and solid and liquid gastric emptying in diabetes mellitus. Eur J Nucl Med 18: 229-234
28. Mecklenbeck W, Rathmann W, Vosberg H (1991) Gastric emptying in diabetic neuropathy: two different forms of disturbed kinetics. Eur J Nucl Med 18: FP-3H3-1 (Abstract)