Implications of inducible nitric oxide synthase expression and enzyme activity

Antioxidants and Redox Signaling

Volumn 2, Issue 3, 2000, Pages 585-605

  Kroncke K D ^a   Suschek, C V ^a   Kolb Bachofen, V ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE;

APOPTOSIS; CELL PROLIFERATION; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033743934     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/15230860050192341     Document Type: Review

References (180)

1. Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lacteral sclerosis
2. Increased inducible nitric oxide synthase in skeletal muscle biopsies from patients with chronic heart failure
3. Nitiric oxide controls Src kinase activity through a sulfhydryl group modification-mediated tyr-527-independent and tyr-416-linked mechanism
4. Frequent nitric oxide synthase-2 expression in human colon adenomas: Implication for tumor angiogenesis and colon cancer progression
5. Activation of the inducible form of nitric synthase in the brains of patients with multiple sclerosis
6. Cyclooxygenase is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particular in macrophages
7. Apoptotic cell death of neutrophils in development of skin lesions of patients with anaphylactoid purpura
8. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
9. Inducible NO synthease: Role in cellular signalling
10. The physiological and pathological chemistry of nitric oxide
11. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
12. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
13. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry
14. Nitric oxide mediates intracytoplasmic and intranuclear zinc release
15. Influence of nitric oxide on the intracellular reduced glutathione pool: Different cellular capacities and strategies to encounter NO-mediated stress
16. Zinc finger transcription factors as molecular targets for nitric oxide-mediated immunosuppression: Inhibition of IL-2 gene expression in murine lymphocytes
17. Nitrosative and oxidative modulation of iron regulatory proteins
18. Increased peroxynitrite activity in AIDS dementia complex: Implications for the neuropathogenesis of HIV-1 infection
19. Nitric oxide (NO) disrupts DNA binding of the transcription factor c-Myb in vitro
20. Nitric oxide and mitochondrial respiration
21. A proinflammatory activity of interleukin 8 in human skin: Expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes
22. Nitric oxide and its role in apoptosis
23. The chemistry of DNA damage from nitric oxide and peroxynitrite
24. Inducible nitric oxide synthase is present within atheroscleotic lesions and promotes the formation and activity of peroxynitrite
25. Nitric oxide causes inactivation of the low molecular weight phosphotyrosine protein phosphatase
26. Expression of nitric oxide synthase in human central nervous system tumors
27. Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin
28. Formation of peroxynitrite from S-nitrosothiols and hydrogen peroxide
29. Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques
30. Peroxynitrite formation within the central nervous system in active multiple sclerosis
31. Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelating multiple sclerosis lesions
32. Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque
33. Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel diseases
34. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
35. Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease
36. Nitric oxide and thiol redox regulation of Janus kinase activity
37. Nitric oxide rapidly scavenges tyrosine and tryptophan radicals
38. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
39. Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions
40. Nitric oxide induces apoptosis in mouse thymocytes
41. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis
42. Inducible nitric oxide synthase expression in human cerebral infarcts
43. Chemistry of nitric oxide with protein-bound iron sulfur centers. Insights on physiological reactivity
44. Nitric oxide synthase activity in human lung cancer
45. Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure
46. -OONO) play a major role in cytotoxicity?
47. Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-α
48. Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis
49. Expression of nitric oxide synthase in ulcerative colitis
50. - under physiological conditions. How the radicals do the job
51. Protein nitration in Parkinson's disease
52. Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding
53. Enhanced expression of inducible nitric oxide synthase and nitrityrosine in gastric mucosa of gastric cancer patients
54. Immunolocalization of inducible nitric oxide synthase in synovium and cartilage rheumatoid arthritis and osteoarthritis
55. Tumor necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy
56. What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
57. Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers
58. Exercise intolerance in patients with chronic heart failure and increased expression of inducible nitric oxide synthase in the skeletal muscle
59. Induction of nitric oxide synthase in asthma
60. Nitrosative stress: Activation of the transcription factor OxyR
61. Expression of inducible nitric oxide synthase in human heart failure
62. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
63. Aseptic loosening of total hip replacement. Macrophage expression of inducible nitric oxide synthase and cyclo-oxygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure
64. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease
65. Distribution of inducible nitric oxide synthase in ulcerative colitis
66. Peroxynitrite-mediated tyrosine nitration cytalyzed by superoxide dismutase
67. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism
68. S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione
69. Interferon-β-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas
70. Nitrotyrosine formation in the airways and lung parenchyma of patients with asthma
71. Expression of inducible NOS in human glomerulonephritis: The possible source is infiltrating monocytes/macrophages
72. NO inhibits cytokine-induced iNOS expression and NF-κB activation by interfering with phosphorylation and degradation of IκB-α
73. Localization of nitric oxide synthase in human nasal mucosa with nasal allergy
74. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
75. Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release
76. Nitric oxide as a bifunctional regulator of apoptosis
77. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
78. Expression of inducible nitric oxide synthase (NOS) in bone marrow cells of myelodysplatic syndromes
79. Selective expression of inducible nitric oxide synthase in human prostate carcinoma
80. Immunolocalization of inducible nitric oxide synthases in human bladder cancer
81. Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue
82. Expression of inducible nitric oxide synthase activity in human colon epithelial cells: Modulation by T-lymphocyte derived cytokines
83. Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy
84. Role of nitric oxide in Sjogren's syndrome
85. Inactivation of zinc finger transcription factors provides a mechanism for a gene-regulatory role of nitric oxide
86. Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide
87. Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9
88. Nitric oxide: Cytotoxicity versus cytoprotection. How, why, when, and where?
89. Inducible nitric oxide synthase in human diseases
90. Inducible nitric oxide production and expression of transforming growth factor-β1 in serum and CSF after cerebral ischaemic stroke in man
91. Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus
92. Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis
93. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds
94. Nitric oxide signaling: A possible role for G proteins
95. Nitric oxide-stimulated guanine nucleotide exchange on p21(ras)
96. Differential activation of mitogen-activated protein kinases by nitric oxide-related species
97. A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction
98. Kinetic modeling of the nitric oxide gradient generated in vitro by adherent cells expressing inducible nitric oxide synthase
99. Inactivation of ribonucleotide reductase by nitric oxide
100. Nitric oxide and inflammatory bowel disease: Evidence for local intestinal production in children with active colonic disease
101. Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle
102. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation
103. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
104. 2 within the hydrophobic interior of biological membranes
105. Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer
106. S-transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide
107. NO: An inhibitor of cell death
108. Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions. Colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins
109. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts
110. Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues
111. Expression of inducible nitric oxide synthase and formation of peroxynitrite in posttransplant obliterative bronchiolitis
112. Inhibition of NF-κB DNA binding by nitric oxide
113. Immunohistochemical localization of nitric oxide synthase and the oxidant peroxynitrite in lung transplant recipients with obliterative bronchiolitis
114. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients
115. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
116. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide
117. Nitric oxide synthase is expressed in human macrophages during foreign body inflammation
118. Nitric oxide levels in ehaled air and inducible nitric oxide synthase immunolocalization in pulmonary sarcoidosis
119. Effects of hydrogen peroxide, nitric oxide and antioxidants on NF-κB
120. Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon
121. Nitric oxide as a secretory product of mammalian cells
122. Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos
123. Nitric oxide inhibition of lipid peroxidation: Kinetics of reaction with lipid peroxyl radicals and comparison with α-tocopherol
124. Inducible nitric oxide synthase and nitrotyrosine are found in monocytes/macrophages and/or astrocytes in acute, but not in chronic, multiple sclerosis
125. Inducible nitric oxide synthase demonstrated in allergic and irritant contact dermatitis
126. Detection of nitric oxide and nitric oxide synthases in psoriasis
127. Regulation of cellular thiol redox status by nitric oxide
128. Expression of inducible nitric oxide synthase in human burn wounds
129. Lack of tyrosine nitration by peroxynitrite generated at physiological pH
130. Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo
131. + depletion
132. Inducible nitric oxide synthase expression in smooth muscle cells and macrophages of human transplant coronary artery disease
133. Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors
134. Inducible nitric oxide synthase expression in vascular and glomerular structures of human chronic allograft nephropathy
135. Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck
136. Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: Pathogenic relationship to the acquired immunodeficiency syndrome dementia complex
137. Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses
138. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides
139. Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis
140. Inducible nitric oxide synthase and tumor necrosis factor-α in myocardium in human dilated cardiomyopathy
141. Inducible nitric oxide synthase is expressed in granuloma pyogenicum
142. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
143. Widespread peroxynitrite-mediated damage in Alzheimer's disease
144. Nitric oxide inhibits c-Jun N-terminal kinase (JNK2) via S-nitrosylation
145. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IκBα
146. Neuronal DNA damage precedes tangle formation and is associated with upregulation of nitrotyrosine in Alzheimer's disease brain
147. Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 up-regulation
148. Inducible nitric oxide synthase with transitional cell carcinoma of the bladder
149. Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection
150. Production of human-inducible nitric oxide synthase in radicular cysts
151. Cytokine regulation on the synthesis of nitric oxice in vitro by chronically infected human polymorphonuclear leucocytes
152. Frequent expression of inducible nitric oxide synthase in esophageal squamous cell carcinomas
153. Presence of inducible nitric oxide synthase, nitrotyrosine, CD68, and CD14 in the small intestine in celiac disease
154. Cell death and oxidative damage in inflammatory myopathies
155. Nitric oxide synthase activity in human breast cancer
156. Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma
157. Investigations of S-transnitrosylation reactions between low- and high-molecular weight S-nitroso compounds and their thiols by high-performance liquid chromatography and gas chromatography-mass spectrometry
158. Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis
159. Acceleration of peroxynitrite oxidations by carbon dioxide
160. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity
161. Inducible nitric oxide synthase (iNOS) in the human heart: Expression and localization in congestive heart failure
162. Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer
163. Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients
164. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease
165. NF-κB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages
166. A Sp1 binding site of the tumor necrosis factor α promoter functions as a nitric oxide response element
167. Identification of inducible nitric oxide synthase in human macrophages surrounding loosened hip protheses
168. Nitric oxide synthases in kaposi's sarcoma are expressed predominantly by vessels and tissue macrophages
169. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels
170. Expression of nitric oxide synthase isoforms after myocardial infarction in humans
171. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas
172. The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo
173. Nitric oxide synthase expression in cervical spinal cord in sporadic amyotrophic lateral sclerosis
174. Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders
175. Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
176. Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis
177. Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis
178. Mass spectrometric analysis of nitric oxide-modified caspase-3
179. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity