Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis

Gut

Volumn 42, Issue 2, 1998, Pages 180-187

  Kimura, H ^a   Hokari, R ^a   Miura, S ^a   Shigematsu, T ^a   Hirokawa, M ^a   Akiba, Y ^a   Kurose, I ^a   Higuchi, H ^a   Fujimori, H ^a   Tsuzuki, Y ^a   Serizawa, H ^a   Ishii, H ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Colonic mucosa; Nitric oxide; Nitric oxide synthase; Peroxynitrite; Ulcerative colitis

Indexed keywords

NITRIC OXIDE SYNTHASE; PEROXYNITRITE;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON BIOPSY; COLON MUCOSA; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 7144253803     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.2.180     Document Type: Article

References (40)

1. Miller MJS, Sadowska-Krowicka H, Chotinaruemol S, et al. Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther 1993;264:11-16.
2. Middleton SJ, Shorthouse M, Hunter JO. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993;341:465 6.
3. Yamada T, Sartor RB, Marshall S, et al. Mucosal injury and inflammation in a model of granulomatous colitis in rats. Gastroenterology 1993;104:759-77.
4. Boughton-Smith NK, Evans SM, Hawkey CJ, et al. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 1993;342:338-40.
5. Grisham MB, Specian RD, Zimmerman TE. Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis. J Pharmacol ExpTher 1994;271:1114-21.
6. Aiko S, Grisham MB. Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats. Gastroenterology 1995;109:142 50.
7. Lundberg JON, Hellstrom PM, Lundberg JM, Alving K. Greatly increased luminal nitric oxide in ulcerative colitis. Lancet 1994;344:1673-4.
8. Rachmilewitz D, Stamler JS, Bachwich D, et al. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Gut 1995; 36:718 23.
9. Hogaboam CM, Jacobson K, Collins SM, Blennerhassett MG. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am J Physiol 1995;268: G673 G684.
10. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002 12.
11. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992;6:3051 64.
12. Henry Y, Lepoivre M, Drapier JC, et al. EPR characterization of molecular targets for NO in mammalian cells and organelles. FASEB J 1993;7:1124 34.
13. Nussler AK, Billiar TR. Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol 1993;54: 171 8.
14. Stuehr DJ, Nathan CF Nitric oxide: a macrophage product responsible tor cytostasis and respiratory inhibition in tumor target cells.J Exp Med 1989;169:1543 55.
15. Kurose I, Miura S, Fukumura D, et al. Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst. Cancer Res 1993;53:2676 82.
16. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxyntrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620 5.
17. Miles AM, Owens MW, Milligan S, et al. Nitric oxide synthase in circulating vs extravasataed polymorphonuclear leukocytes. J Leukoc Biol 1995;58:616 22.
18. Sartor RB. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 1994;106:533 9.
19. Tepperman BL, Brown JF, Whittle BJR. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol 1993;265:G214-G218.
20. Dignass AU, Podolsky DK, Rachmilewitz D. NOx generation by cultured small intestinal epithelial cells. Dig Dis Sci 1995;40:1859-65.
21. Hibi T, Ohara M, Kobayashi K, et al. Enzyme linked immunosorbent assay (ELISA) and immunoprecipitation studies on anti-goblet cell antibody using a mucin producing cell line in patients with inflammatory bowel disease. Gut 1994; 35:224 30.
22. Knowles RG, Merrett M, Salter M, Moncada S. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J 1990;270:833 6.
23. Riley SA, Mani V, Goodman MJ, et al. Comparison of delayed release 5-aminosalicylic acid (mesalazine) and sulphasalazine in the treatment of mild to moderate ulcerative colitis relapse. Gut 1988;29:669 74.
24. Miller MJS, Thompson JH, Zhang X-J, et al. Role of inducible nitric oxide synthabe expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 1995;109: 1475 83.
25. Kirsner JB, Shorter RG. Inflammtory bowel disease, 3rd ed. Philadelphia: Lea & Febiger, 1988.
26. Huie RE, Padmaja S. The reaction of NO with superoxide. Free Radic Res Common 1993;18:195 9.
27. Beckman JS, Crow JP. Pathological implications of nitric oxide, superoxide, and peroxynitrite formation. Biochem Soc Trans 1993;21:330-4.
28. Szabo C, Salzman AL, Ichiropoulos H. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. FEBS Lett 1995;363:235 8.
29. Wizemann TM, Gardner CR, Laskin JD, et al. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. J Leukoc Biol 1994;56:759-68.
30. Kooy NW, Royall JA, Ye YZ, et al. Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 1995;151:1250-4.
31. Belenky SN, Robbins RA, Rennard SI, et al. Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro. J Lab Clin Med 1993;122:388-94.
32. Belenky SN, Robbins RA, Rubinstein I. Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro. J Lcukoc Biol 1993;53:498 503.
33. Granger DL, Taintor RR, Cook JL, Hibbs JB. Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration. J Clin Invest 1980;65:357-70.
34. Hibbs JB, Taintor RR, Vavrin Z. Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages. Biochem Biophys Res Commun 1984;123:716-23.
35. Kwon NS, Stuehr DJ, Nathan CF. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med 1991;174:761 7.
36. Weitzman SA, Gordon LI. Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 1990;76:655 63.
37. Thomas EL, Jefferson MM, Bennett JJ, Learn DB. Mutagenic activity of chloramines. Mutat Res 1987;188: 35-43.
38. Nguyen T, Brunson D, Crespit C, et al. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci USA 1992;89:3030-4.
39. Grisham MB, Yamada T. Neutrophils, nitrogen oxides, and inflammatory bowel disease. Ann NY Acad Sci 1992;664: 103-10.
40. Roediger WEW, Law-son MJ, Radclifie BC. Nitrite from inflammatory cells: a cancer risk factor in ulcerative colitis? Dis Colon Rectum 1990;33:1034-6.