Zinc finger transcription factors as molecular targets for nitric oxide-mediated immunosuppression: Inhibition of IL-2 gene expression in murine lymphocytes

Molecular Medicine

Volumn 5, Issue 11, 1999, Pages 721-730

  Berendji, D ^a   Kolb Bachofen, V ^a   Zipfel, P F ^a   Skerka, C ^a   Carlberg, C ^a   Kroncke K D ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; INTERLEUKIN 2; NITRIC OXIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; EFFECTOR CELL; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS INHIBITION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TARGET CELL; TRANSCRIPTION REGULATION;

EID: 0033276622     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402096     Document Type: Article

References (37)

1. Nitric oxide as a secretory product of mammalian cells
2. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities
3. Nitric oxide: A pathogenic factor in autoimmunity
4. The multiplex function of nitric oxide in (auto)immunity
5. Inducible nitric oxide synthase in human diseases
6. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
7. Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine
8. Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway
9. Immunosuppression induced by nitric oxide and ist inhibition by interleukin-4
10. Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection
11. Nitric oxide in autoimmune disease: Cytotoxic or regulatory mediator?
12. Is there a role for nitric oxide in regulation of T cell secretion of IL-2?
13. Inhibition of IL-2 production by nitric oxide: A novel self-regulatory mechanism for Th1 cell proliferation
14. Nitric oxide increases interleukin-4 expression in T lymphocytes
15. Nitric oxide inhibits the secretion of T-helper 1- and T-helper 2-associated cytokines in activated human T cells
16. Nitric oxide inhibits the proliferation of T-helper 1 and 2 lymphocytes without reduction in cytokine secretion
17. The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
18. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
19. Zinc fingers
20. A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1
21. The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells
22. Nitric oxide destroys zinc-sulfur dusters inducing zinc release from metallthionein and inhibition of the zinc finger-type yeas transcription factor LAC9
23. Nitric oxide mediates intracytoplasmic and intranuclear zinc release
24. Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide
25. Methods for the detection of nitric oxide interaction with zinc finger proteins
26. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
27. A simple and very efficient method for generating cDNA libraries
28. Unique structure of murine interleukin-2 as deduced from cloned cDNAs
29. Protein measurement with the foline phenol reagent
30. Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by lymphoma cells
31. Role of zinc-coordination and of the glutathione redox couple in the redox susceptibility of human transcription factor Sp1
32. The DNA-binding of Sp1 is affected by redox changes
33. Induction and stabilization of IκBα by nitric oxide mediates inhibition of NF-κB
34. Inhibition of NF-κB DNA binding by nitric oxide
35. Effects of hydrogen peroxide, nitric oxide and antioxidants on NF-κB
36. Modulation of Ap-1 activity by nitric oxide (NO) in vitro: NO-mediated modulation of AP-1
37. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA