The inflammatory process in aging

Reviews in Clinical Gerontology

Volumn 10, Issue 3, 2000, Pages 207-222

  Hae, Young Chung ^a   Hyon, Jeen Kim ^a   Kyung, Jin Jung ^a   Ji, Sung Yoon ^a   Mi, Ae Yoo ^a   Kyu, Won Kim ^a   Byung, Pal Yu ^a  

^a Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; NITRIC OXIDE; PEROXYNITRITE; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; PROSTANOID; REACTIVE OXYGEN METABOLITE; THROMBOXANE A2; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

AGING; ALZHEIMER DISEASE; BINDING AFFINITY; CELL PROTECTION; CELLULAR IMMUNITY; DNA BINDING; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMORAL IMMUNITY; INFLAMMATION; LIPOGENESIS; PROMOTER REGION; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033661513     PISSN: 09592598     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0959259800010327     Document Type: Review

References (149)

1. Aging and oxidative stress: Modulation by dietary restriction
2. Free radical theory of aging: Nutritional implications
3. Biological sites and mechanism of free radical production
4. Xanthine dehydrogenase/xanthine oxidase and oxidative stress
5. Role of cellular energetics in ischemia-reperfusion and ischemic preconditioning of myocardium
6. The inflammation hypothesis of aging: Molecular modulation by calorie restriction
7. Oxidative stress and vascular aging
8. Age-related differences in cytokine secretion
9. Reactive nitrogen and oxygen species transducers as well as effects
10. Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice
11. Evidence for in vivo peroxynitrite production in human acute lung injury
12. Generation of reactive oxygen intermediates, activation of NF-kappa B, and induction of apoptosis in human endothelial cells by glucose: Role of nitric oxide synthase?
13. Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells
14. Regulation of xanthine oxidase by nitric oxide and peroxynitrite
15. Arachidonic acid and its metabolites in cerebral ischemia
16. 2 in a murine model of inflammation: Possible role of cyclooxygenase-2
17. Prostaglandin and thromboxane biosynthesis in isolated platelet-free human monocytes. III. The induction of cycloxygenase by colony stimulating factor-1
18. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1 tumor necrosis factor-alpha, and lipopolysaccharide
19. The effect of age on circulating 6-keto-prostaglandin F1alpha in humans
20. Aging: Effects on the prostaglandin production by skeletal muscle of male rhesus monkeys (Macaca mulatta)
21. Age-related decrease in prostacyclin biosynthetic activity in rat aortic smooth muscle cells
22. Age-related decline in prostacyclin synthesis by human aortic endothelial cells. Qualitative and quantitative analysis
23. Altered prostaglandin synthesis and impaired sodium conservation in the kidneys of old rats
24. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E
25. Inflammation and Alzheimer's disease: Mechanisms and therapeutic strategies
26. Inflammation, infection, and cardiovascular risk: How good is the clinical evidence?
27. Change of the rat xanthine oxidase/dehydrogenase and uric acid formation by aging and dietary restriction in the liver
28. In vitro and ex vivo xanthine oxidoreductase activity in rat and guinea-pig hearts using hypoxanthine or xanthine as substrate
29. Modulation of renal xanthine oxidoreductase in aging: Gene expression and reactive oxygen species generation
30. Histamine, xanthine oxidase generated oxygen-derived free radicals and Helicobacter pylori in gastroduodenal inflammation and ulceration
31. Increased expression of xanthine oxidase and insulin-like growth factor I (IGF-I) immunoreactivity in skeletal muscle after strenuous exercise in humans
32. Spontaneous expression of inducible nitric oxide synthase in the hypothalamus and other brain regions of aging rats
33. Nitric oxide-α novel mediator of inflammation
34. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients
35. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats
36. Biochemistry of nitric oxide and its redox-activated forms
37. Oxidation of NO in aqueous solution to nitrite and nitrate: Comparison with enzymatically formed nitric oxide
38. Signal transduction mechanism involving nitric oxide
39. Nitric oxide: A physiologic messenger molecule
40. Redox signaling: Nitrosylation and realted target interactions of nitric oxide
41. Redox regulation of cell signalling
42. Activation of cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation
43. Regulation of signal transduction and gene expression by reactive nitrogen species
44. Widespread peroxynitrite-mediated damage in Alzheimer's disease
45. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production
46. Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis
47. Peroxynitrite and oxidative damage in experimental autoimmune uveitis
48. Cytokine-induced inflammation and long-term stroke functional outcome
49. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity
50. The inhibitory action of Mycobacterium ulcerans soluble factor on monocyte/T cell cytokine production and NF-kappa B function
51. Inhibition of the Kupffer cell inflammatory response by acute ethanol: NF-kappa B activation and subsequent cytokine production
52. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
53. Quantitative intracellular cytokine measurement: Age-related changes in proinflammatory cytokine production
54. Age-related decline in cytokine induced nitric oxide synthase activation and apoptosis in cultured endothelial cells: Minimal involvement of nitric oxide in the apoptosis
55. Monocyte cytokine production in an elderly population: Effect of age and inflammation
56. Age-related differences in cytokine secretion
57. Effect of age and carbon tetrachloride on cytokine concentrations in rat liver
58. Regional difference of ROS generation, lipid peroxidation, and antioxidant enzyme activity in rat brain and their dietary modulation
59. Environmental particulate-mediated cytokine production in lung epithelial cells (A549): Role of preexisting inflammation and oxidant stress
60. Association between oxidative stress and cytokine production in nickel-treated rats
61. Expression of oxidative stress-responsive genes and cytokine genes during caerulein-induced acute pancreatitis
62. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
63. Augmented expression of inducible NO synthase in vascular smooth muscle cells during aging is associated with enhanced NF-kappa B activation
64. Predominant role of NF-kappa B p65 in the pathogenesis of chronic intestinal inflammation
65. A role for transcription factor NF-kappa B in inflammation
66. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain
67. Inhibition of NFκB by methylchlorogenate from Eriobotrya japonica
68. NFκB and Rel proteins: Evolutionarily conserved mediators of immune responses
69. Fibronectin attachment activates the NF-kappa B p50/p65 heterodimer in fibroblasts and smooth muscle cells
70. The inducible transcription activator NFκB: Regulation by distinct protein subunits
71. NFκB and Rel: Participants in a multiform transcriptional regulatory system
72. Function and activation of NFκB in the immune system
73. Antioxidant treatment of thymic organ cultures decreases NF-kappa B and TCF1 (alpha) transcription factor activities and inhibits alpha beta T cell development
74. Redox regulation of lipopolysaccharide (LPS)-induced interleukin-8 (IL-8) gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells
75. The role of oxidative stress in the long-term glycation of LDL
76. Aging-induced up regulation of nuclear binding activities of oxidative stress responsive NFκB transcription factor in mouse cardiac muscle
77. Age-related changes in the regulation of transcription factor NFκB in rat brain
78. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B
79. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain
80. The effect of age on cyclooxygenase-2 gene expression. NFκB activation and IkappaBalpha degradation
81. Inflammation of the brain in Azheimer's Disease: Implication for therapy
82. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease
83. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
84. Transcription factor NFκB is activated in primary neurons by amyloid-β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
85. Involvement of NFκB p50/p65 heterodimer in activation of the upstream enhancer element
86. Activation of the interleukin-6 gene expression through the NF-kappa B transcription factor
87. Lipopolysacchride induction of the tumor nectosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappa B transcription factor
88. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene
89. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NF kappa B dependent mechanism
90. The betaamyloid precursor protein and its derivatives: From biology to learning and memory processes
91. It all sticks together - The APP-related family of proteins and Alzheimer's disease
92. Crucial role of group IIA phospholipase A(2) in oleic acid-induced acute lung injury in rabbits
93. Requirement of NFκB activation to suppress p53-independent apoptosis induced by oncogenic Ras
94. A requirement for NF-kB activation in Bcr-Abl-mediated transformation
95. New insights into the role of nuclear factor-kB, a ubiquitous transcription factor in the initiation of disease
96. Differential regulation of the c-myc oncogene promoter by the NFκB rel family of transcription factors
97. Does NF-kappa B relieve the transcription block in c-myc?
98. Receptor-specific regulation of NF-kappa B, c-Myc and Fas-mediated apoptosis in primary B cells
99. Role of the Rel-family of transcription factors in the regulation of c-myc gene transcription and apoptosis of WEHI 231 murine B-cells
100. Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated I kappa B alpha overexpression
101. bcl-2 over-expression enhances NF-kappa B activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cells
102. Selective activation of NF-kappa B subunits in human breast cancer: Potential roles for NF-kappa B2/p52 and for Bcl-3
103. JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosis
104. Endotherial nuclear factor-kappa B and the initiation of the atherosclerotic lesion
105. Free radicals and diabetes
106. Estrogen protects peripheral and cerebral blood vessels from toxicity of Alzheimer peptide amyloid-beta and inflammatory reaction
107. Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenyl-acetaldehyde with the amino headgroup of phosphatidyl-ethanolamine and phosphatidylserine
108. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
109. Inflammation, the acute phase response and atherosclerosis
110. Fluid Shear stress as a regulator of gene expression in vascular cells: Possible correlation with diabetic abnormalities
111. Free radicals and activated oxygen
112. Identification of vascular endothelial genes differentially reponsive to fluid mechanical stimula: Cyclooxygenase-2, manganase superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress
113. Dietary modulation of prostanoid synthesis in the aging process: Role of cyclooxygenase-2
114. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion
115. Angiotensin induces inflammatory activation of human vascular smooth muscle cells
116. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats
117. An endothelial receptor for oxidized low density lipoprotein
118. Oxidized low density lipoprotein induces activation of the transcription factor NF kappa B in fibroblasts, endothelial and smooth muscle cells
119. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice
120. Activation of receptor for advanced glycation end products
121. CD40 signaling in vascular cells: A key role in atherosclerosis?
122. Regulation of vascular smooth-muscle cell growth by angiotensin II
123. Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?
124. Age-related effects in T cell activation and proliferation
125. Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease
126. Biologic basis for interleukin-1 in disease
127. Cytokines regulate vascular functions related to stability of the atherosclerotic plaque
128. Update on the biologic effects of macrophage colony-stimulating factor
129. Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells
130. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: A role for apoptosis in plaque thrombogenicity
131. Tissue-factor antigen and activity in human coronary atherosclerotic plaques
132. Inflammation in atheroma: Implications for plaque rupture and platelet-collagen interaction
133. Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells
134. The role of VCAM-1 molecule in the pathogenesis of rheumatoid synovitis
135. Endothelial-leukocyte adhesive interactions in inflammatory diseases
136. Endothelial adhesion molecules in health and disease
137. Cellular adhesion molecules on vascular smooth muscle cells
138. Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis
139. Insight into atherosclerosis: A review of c-myc and the vascular smooth muscle cell
140. Primary endothelial dysfunction: Atherosclerosis
141. Pathophysiology and treatment of carbon monoxide poisoning
142. Hypoxia induces cell-specific changes in gene expression in vascular wall cells: Implications for pulmonary hypertension
143. Endothelial function and hemostasis
144. Endothelial dysfunction: From physiology to therapy
145. Endothelial cell responses to hypoxic stress