Garlic and its medicinal potential

Inflammopharmacology

Volumn 8, Issue 2, 2000, Pages 123-148

  Afzal, M ^a   Ali, M ^a   Thomson, M ^a   Armstrong, D ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Antibacterial; Antidiabetic; Antioxidant; Atherosclerosis; Cardiovascular; Garlic (Allium sativum L.); Hy perlepemia; Immunoprotective; Onion (Allium cepa L.)

Indexed keywords

CHOLESTEROL;

ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; DIABETES MELLITUS; DRUG POTENCY; GANGRENE; GARLIC; HYPERLIPIDEMIA; IMMUNITY; INFECTION RISK; ONION; PRIORITY JOURNAL; SPICE;

ALLIUM SATIVUM;

EID: 0033651179     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/15685600038134     Document Type: Article

References (198)

1. Allium sativum (garlic) a natural antibiotic
2. Therapeutic actions of garlic constituents
3. Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity. Effect of raw versus boiled garlic extract on the synthesis of prostanoids
4. Effects of sulphinpyrazone on platelet synthesis and platelet release of of serotinin
5. Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extracts of garlic in rabbits
6. Antithrombotic activity of garlic: Its inhibition of the synthesis of thromboxane-TXB2 during infusion of arachidonic acid and collagen in rabbits
7. Changes in the level of lactic dehydrogenase and transketolase in liver and red cells of rats after treatment with garlic extracts
8. Aqueous extracts of garlic (Allium sativum) inhibit prostaglandin synthesis in ovine ureter
9. Preparation of thiosulphinates
10. Histopathological evidence of protective action of garlic against collagen and arachidonic acid toxicity in rabbits
11. Dietary components modify the ability of garlic to suppress 7,12-dimethylbenz(a)anthracene-induced mammary DNA adducts
12. Oxidants, antioxidants, and the degenerative diseases of aging
13. Isolation and characterization of larvicidal principle of garlic
14. Occupational asthma induced by garlic dust
15. Allicin from garlic strongly inhibits cysteine proeinases and cytopathic effects of Entamoeba histolytica
16. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure
17. Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dipyridamole on human platelets
18. Platelet aggregation inhibitor in garlic
19. Comparative effect of clofibrate, garlic and onion on alimentary hyperlipemia
20. Effect of essential oil of onion (allyl propyl disulphide) on blood glucose, free fatty acid and insulin levels of normal subjects
21. Lipid lowering effect of allicin (diallyl disulphide oxide) on long-term feeding to normal rats
22. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with Streptozotocin induced diabetes mellitus
23. Onion and platelet aggregation
24. Isolation, purification, identification, synthesis, and kinetics of activity of the anticandidal component of Allium sativum and a hypothesis of its mode of action
25. Inhibitor of cylooxygenase and lipoxygenase in onions
26. Inhibition of soybean lipoxigenase and mouse skin tumor promotion by onion and garlic components
27. The distribution and metabolism of arachidonic in rabbit platelets during aggregation and its modification by drugs
28. The organosulphur chemistry of the genus Allium. Implications for the organic chemistry of sulphur
29. (E.Z)-Ajoene: A potent antithrombotic agent from garlic
30. Antithrombotic organosulphur compounds from garlic, structural mechanistic and synthetic studies
31. Lipoxygenase inhibitors from the essential oil of garlic. Markovnikov addition of the allyldithio radical to olefins
32. Allium chemistry: HPLC analysis of thiosulphinates from onion, garlic, wild garlic (ramsmons), leek, scallion, shallot, slephant (great-headed) garlic, chive, and Chinese chive. Uniquely high allyl to methyl ratios in some garlic samples
33. G protein-coupled P2 purinoceptors: From molecular biology to functional responses
34. The medical uses of garlic-fact and fiction
35. Letter: Essential oil of garlic in prevention of atherosclerosis
36. The protective action of essential oils of onion and garlic in cholesterol-fed rabbits
37. Effect of the essential oils of garlic and oinon on alimentary hyperlipemia
38. Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits
39. Effect of garlic on human platelet aggregation
40. Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary arterial disease
41. Garlic as a platelet inhibitor
42. Inhibition of cytochrome P-450 2El by diallyl sulphide and its metabolites
43. Protein prenylation. Mad bet for Rab
44. Allium chemistry: Identification of organosulphur compounds in ramp (Allium tricoccum) homogenates
45. Allicin, the antibacterial principle of Allium sativum II. Determination of chemical structure
46. A case-control study of gastric cancer and diet in Italy
47. 2+-antagonists verapamil and diltiazem and by trifluorperzaine
48. Glucokinin. An apparent synthesis in normal animal of a hypoglycaemic producing principle, Animal passage of the principle
49. Antimicrobial activity of crude juices of Allium ascalonicum, Allium cepa and Allium stavium
50. Effects of ASA on thromboxane and prostacyclin synthesis by rabbit aorta and pulmonary artery
51. Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor
52. Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence
53. Consumption of onions and a reduced risk of stomach carcinoma
54. Anti-asthmatic effects of onions alkensulphinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo
55. Chemoprevention of clinically induced skin tumor development by diallyl sulphide and diallyl disulphide
56. The analysis of S-alk(en)yl-L-cysteine sulphoxides (flavour precursors) from species of Allium by high performance liquid chromatography
57. The antimicrobial activity of garlic and onion extracts
58. Metabolism and functions of trypanothione in the kinetoplastida
59. Lack of causal relationship between the vasodilator effects of papaverine and cyclic AMP production in the dog basilar artery
60. Nitric oxide reversibly suppresses xanthine oxidase activity
61. Cancer prevention by organosulphur compounds from garlic and onion
62. Diabetes increases excretion of urinary malonaldehyde conjugates in rats
63. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: Crystallographic, kinetic and spectroscopic studies
64. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and Hep G2 cells
65. Cyclic AMP and platelet prostaglandin synthesis
66. Antiplatelet activity in onion (Allium cepa) is sulphur dependent
67. Effect of diallyl sulphide, a naturally occurring anticarcinogen, on glutathione-dependent detoxification enzymes of female CD-1 mouse tissues
68. Metabolic activation of carcinogens
69. Tanakan inhibits platelet-activating factor-induced platelet aggregation in healthy male volunteers
70. DNA damage in the kidney of diabetic rats exhibiting microalbuminuria
71. Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides
72. A spectrophotometric method for quantitative determination of allicin and total garlic thiosulphinates
73. Adrenocorticotropic hormone: Adrenocortocotropic hormone: Adrenocorticoid steroids biosynthesis
74. Lipid peroxide levels in diabetics with micro and macroangiopathies
75. Protective effects of diallylsulphide on acetaminophen-induced toxicities
76. Hydroxyl radical production and autooxidative glycosylation
77. Enrichment of selenium in allium vegetables for cancer prevention
78. Effect of S-methylcysteine sulphoxide, S-allylcysteine sulphoxide and related sulphur-containing amino acids on lipid metabolism of experimental hypercholesterolemic rats
79. Hypoglycemic action of onion and garlic
80. Garlic in alloxan-induced diabetic rabbits
81. Elevated lipid peroxidation levels in red blood cells of streptoazotocin treated in diabetic rats
82. Allicin characterization and its determination by HPLC
83. Characterization of an alliin lyase preparation from garlic (Allium sativum)
84. Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin
85. Inhibition of human glutathione reductase by the nitrosourea drugs, 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis
86. The effects of garlic oil upon serum indicators of liver function
87. Inhibition of platelet aggregation from onion
88. Garlic (Allium sativum) and onion (Allium cepa): A review of their relationship to cardiovascular disease
89. Motility of the human ureter with special reference to the effect of indomethacin
90. Protein prenylation: Key to ras function and cancer intervention?
91. Enhanced expression of rat microsomal epoxide hydrolase gene by organosulphur compounds
92. Garlic, onions and cardiovascular risk factors. A review of the evidence from human experiments with emphasis on commercially available preparations
93. Allicin in knoblauch-Allium sativum L. und knoblauchpraparatch: Gehaltsbestimmung headspace-gaschromatography
94. Allixin, a stress compound from garlic. Prehepatic fate of the organosulphur compounds derived form garlic (Allium sativum)
95. Protective effects of an aged garlic extract on doxorubin-induced cardiotoxicity in the mouse
96. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design
97. Pharmacological trials with some domestic plants
98. Volatile compounds thermally generated from S-propylcysteine and S-propylcysteine sulphoxide: Aroma precursors of Allium vegetables
99. Inhibition of cytochrome P45021 expression by organosulphur compounds allylsulphide, allylmercaptan and allylmethylsulphide in rats
100. Volatile garlic odor components: Gas phases and adsorbed exhaled air analysed by headspace gas chromatography-mass spectrometry
101. Presence of allinase in isolated vacuoles and of alkyl cysteine sulphoxides in the cytoplasm of bulbs of onion (Allium cepa)
102. Identification and HPLC quantitation of the sulphides and dialk(en)yl thiosulphinates in commercial garlic products
103. Allicin and other thiosulphinates and their precursors and transformation products from garlic and garlic products
104. Natural inhibitors for protein prenyltransferase
105. Protective effect of diallyl sulphone against acetaminophen-induced hepatotoxicity in mice
106. Antiparasitic activity of diallyl trisulphide (Dasuansu) on human and animal pathogenic protozoa (Trypanosoma sp., Entamoeba histolytica and Giardia lamblia) in vitro
107. Transcellular biosynthesis of Eicosanoids
108. Effect of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis
109. Altered arachidonic acid metabolism in platelets inhibited by onion or garlic extracts
110. Altered arachidonic metabolism in platelets inhibited by onion or garlic extracts
111. Biological nature of platelet inhibitors from Allium cepa, Allium sativum and Auricularia polytrica
112. Antiplatelet constituents of garlic and onion
113. Nitric oxide a mediator of the effects of garlic
114. Hypolipidemic effect of garlic protein substituted for casein in diet of rats compared to those of garlic oil
115. The pharmacological effects of allicin, a constituents of garlic oil
116. Garlic: Its anticarcinogenic and antitumorigenic properties
117. Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions
118. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic (Allium sativum)
119. Spectrophotometric assay for allicin and alliinase (alliin lyase) activity: Reaction of 2-nitro-5-thiobenzoate with thiosulphinates
120. Isolation, characterization, identification and synthesis of an inhibitor of platelet function from Allium sativum
121. Characterization of a potent inhibitor of platelet aggregation and realease reaction isolated from Allium sativum (garlic)
122. Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements
123. The fungicidal and fungistatic effects of an aqueous garlic extract on medically important yeast-like fungi
124. Allixin, a phytoalexin produced by garlic and its analogues as novel exogenous substrances with neurotrophic activity
125. Effect of onion and garlic on blood coagulation and fibrinolysis in vitro
126. Antioxidative activities of vegetables of Allium species. Studies on natural antioxidants Part II
127. Fractionation of antioxidant extracted from garlic. Studies on natural antioxidants Part III
128. Garlic: Its cardioprotective properties
129. Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C
130. The C-S lyases of higher plants: Preparation and properties of homogeneous alliin lyase from garlic (Allium sativum)
131. Effect of garlic and onion oils on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione and ornithine decarboxylase induction in isolated mouse epidermal cells treated with tumor promoters
132. Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils
133. In vivo activity of ajoene against rodent malaria
134. Inhibition of platelet aggregation by onion extracts
135. Steady-state kinetic mechanism of Ras farnesyl: Protein transferase
136. Evaluation of hydroxyl radical-scavenging properting of garlic
137. Antiperoxide effect of garlic protein in alcohol fed rats
138. Modulation of rat hepatic cytochrome P450 activity by garlic organosulphur compounds
139. Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme
140. Inhibition of purified p21ras farnesyl: Protein transferase by Cys-AAX tetrapeptides
141. Ajoene, the anti-platelet compound derived front garlic, specfically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity
142. Mobilization of arachidonic acid in human platelets, kinetics and calcium dependency
143. The mode of action of allicin: Trapping of radicals and teraction with thiol containing proteins
144. Effect of sulphhydryl inhibitors on platelet agglutinability
145. Onion, garlic and experimental atherosclerosis
146. Effects of dietary garlic and temporal drift on platelet aggregation
147. Lipid peroxide levels in plasma of diabetic patients
148. Garlic powder and allyl sulphur compounds enhance the ability of dietary selenite to inhibit 7,12-bimethylbenz[a]anthracene-induced mammary DNA adducts
149. Injuries to cultivated BJA-B cells by ajoene, a garlic-derived natural compound: Cell viability, glutathione metabolism and pools of acidic amino acids
150. The cytotoxic effect of ajoene, a natural product from garlic investigated with different cell lines
151. Disulphide reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria
152. Anti-aggregatory actions of calcium channel blockers in cat platelets
153. Inhibition of human glutathione, reductase by 10-arylisoalloxazines: Crystallographic, kinetic and electrochemical studies
154. Hypoglycemic effect of fenugreek seeds in non-insulin dependant diabetic subjects
155. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn
156. Antiperoxide effects of S-allyl cysteine sulphoxide isolated from Allium sativum Linn. and gugulipid in cholesterol diet fed rats
157. Anti-diabetic effects of onion and garlic sulphoxide amino acids in rats
158. Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines
159. Cysteine-S-conjugate beta-luase activity and pyridoxal phosphate binding site of onion alliin lyase
160. Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulphides
161. Mechanism of nitric oxide release from S-nitrosothiols
162. Certain biochemical effects of garlic oil on rate maintained on a high fat-high cholesterol diet
163. Effects of organosulphur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse
164. Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system in vitro study
165. Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism
166. Evidence for the mechanism by which garlic inhibits platelet aggregation
167. Effect of onion and ginger consumption on platelet thromboxan production in humans
168. Spices: Antiplatelet activity and prostanoid metabolism
169. Effects of a garlic derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets
170. Vegetables, fruit and colon cancer in the Iowa women's health study
171. Purification and characterization of alliin lyase from Welsh onion, Allium sativum L
172. Chemoprotective effects of capsaicin and diallyl sulphide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine
173. Enhancement by organosulphur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver
174. Effectiveness of garlic on the radical activity in radical generating systems
175. Garlic and circulatory disorders
176. Inhibition of phosphatidylcholine biosynthesis and cell proliferation in Trypanosoma cruzi by ajoene, an antiplatelet compound isolated from garlic
177. Isolation and characterization of alliinase cDNA clones from garlic (Allium sativum L.) and related species
178. Inhibition of fatty acid oxygenases by onion and garlic: Evidence for the mechanism by which these oils inhibit platelet aggregation
179. The isolation of S-methyl-L-cysteine sulphoxide and S-n-propyl-L-cysteinesulphoxide from onion (Allium cepa) and the antibiotic activity of crushed onion
180. Effects of garlic constituents on arachidonate metabolism
181. Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices
182. Chemoprevention of carcinogenesis by minor non-nutrient constituents of diet
183. In vitro virucidal effects of Allium sativum (garlic) extract and compounds
184. Recombinant expression of alliin lyase from garlic (Allium sativum) in bacteria and yeasts
185. Identification and quantification of anticarcinogens in garlic extract and licorice root extract powder
186. Tumor inhibition by sulphhydryl-blocking agent related to an active principle of garlic (Allium sativum)
187. Effects of allylpropyl disulphide isolated from Allium cepa Linn. on high-fat fed rats
188. Lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and mercuric ion reductase - A family of flavoenzyme transhydrogenases
189. Enzyme inhibition by allicin, the active principle of garlic
190. Induction of glutathione S-transferase pi as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene-induced cancer in a murine model
191. Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1
192. A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages
193. Allium vegetables and reduced risk of stomach cancer
194. The action of garlic upon plasma total antioxidant capacity
195. HPLC of S-alk(en)yl-L-cysteine derivatives in garlic including quantitative determination of (+)-S-allyl-L-cysteine sulphoxide (alliin)
196. Effects of acetyl salicyclic acids, and other non-steroidal anti-inflammatory agents and dipyridamole on human blood platelets