Garlic: Its anticarcinogenic and antitumorigenic properties

Nutrition Reviews

Volumn 54, Issue 11 II, 1996, Pages

  Milner, John A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; ORGANOSULFUR DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; CANCER EPIDEMIOLOGY; CANCER INHIBITION; CANCER PREVENTION; CONFERENCE PAPER; DIETARY INTAKE; DNA BINDING; GARLIC; HUMAN; NONHUMAN;

EID: 0030424068     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1996.tb03823.x     Document Type: Conference Paper

References (36)

1. Doll R. The lessons of life: keynote address to the nutrition and cancer conference. Cancer Res. 1992;52:2024s-9s
2. Milner JA. Reducing the risk of cancer. In: Functional Foods. New York: Van Nostrand Reinhold Publishing Company, 1994:39-70
3. Raunio H, Husgafvel-Pursiainen K, Anttila S, Hietanen E, Hirvonen A, Pelkonen O. Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility - a review. Gene 1995;159:113-21
4. Adetumbi MA, Lau BH. Allium sativum (garlic) - a natural antibiotic. Med Hypotheses 1983;12:227-37
5. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 1993;94:632-5
6. Mei X, Wang ML, Xu HX, et al. Garlic and gastric cancer, I: the influence of garlic on the level of nitrate and nitrite in gastric juice. Acta Nutrimenta Sinica 1982;4:53-6
7. You WC, Blot WJ, Chang, YS, et al. Allium vegetables and reduced risk of stomach cancer. J Natl Cancer Inst 1989;81:162-4
8. Steinmetz KA. Kushi LH, Bostick RM, Folsom AR, Potter JD. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am J Epidemiol 1994;139:1-15
9. Dorant E, Van Den Brandt PA, Goldbohm RA. A prospective cohort study on Allium vegetable consumption, garlic supplement use, and the risk of lung carcinoma in The Netherlands. Cancer Res 1994;54:6148-53
10. Dorant E, Van Den Brandt PA, Goldbohm RA, Hermus RJJ, Sturmans F. Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. Br J Cancer 1993;67:424-9
11. Sparnins VL, Barany G, Wattenberg LW. Effects of organosulfur compounds from garlic and onions on benzo(a)pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis 1988;9:131-4
12. Shenoy NR, Choughuley AS. Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines. Cancer Lett 1992;65:227-32
13. Lin X-Y, Liu JZ, Milner JA. Dietary garlic suppresses DNA adducts caused by N-nitroso compounds. Carcinogenesis 1994;15:349-52
14. Liu JZ, Lin RI, Milner JA. Inhibition of 7,12-dimethylbenz(a)-anthracene induced mammary tumors and DNA adducts by garlic powder. Carcinogenesis 1992;13:1847-51
15. Ip C, Lisk DJ, Stoewsand GS. Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutr Cancer 1992;7:279-86
16. Wargovich MJ, Woods C, Eng VWS, Stephens LC, Gray KN. Chemoprevention of nitrosomethylbenzylamine-induced esophageal cancer in rats by the thioether, diallyl sulfide. Cancer Res 1988;48:6872-5
17. Sumiyoshi H, Wargovich MJ. Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds. Cancer Res 1990;50:5084-7
18. Amagase H, Milner JA. Impact of various sources of garlic and their constituents on 7,12-dimethylbenz(a)anthracene binding to mammary cell DNA. Carcinogenesis 1993;14:1627-31
19. Block E. The organosulfur chemistry of the genus Allium - implications for the organic chemistry of sulfur. Angew Chem Int Ed Engl 1992;31:1135-78
20. Brady JF, Wang MH, Hong JY, et al. Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide. Toxicol Appl Pharmacol 1991;108:342-54
21. Liu JZ, Lin XY, Milner JA. Dietary garlic powder increases glutathione content and glutathione S-transferase activity in rat liver and mammary tissues. FASEB J 1992;6(4):A1493
22. Schulte HR. Biochemical events in nitrosamine-induced hepatocarcinogenesis: relevance of animal data to human carcinogenesis. IARC Sci Publ 1987;84:17-9
23. Montesano R, Magee PN. Comparative metabolism in vitro of nitrosamines in various animal species including man. In: Montesano R, Tomatis L, eds. Chemical Carcinogenesis Essays. Vol 10. Lyon, France: IARC Scientific Publications, 1974;39-56
24. Mei X, Wang ML, Han N. Garlic and gastric cancer, II: the inhibitory effect of garlic on the growth of nitrate reducing bacteria and on the production of nitrite. Acta Nutrimenta Sinica 1985;7:173-6
25. Mei X, Lin X, Liu J, et al. The blocking effect of garlic on the formation of N-nitrosoproline in humans. Acta Nutrimenta Sinica 1989;11:141-5
26. Shenoy NR, Choughuley AS. Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines. Cancer Lett 1992;65:227-32
27. 6-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosourea. Carcinogenesis 1990;11:411-7
28. Schaffer EM, Liu JZ, Green J, Dangler CA, Milner JA. Garlic and associated allyl componeents inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis. Cancer Lett1996;102:199-204
29. Ip C, Lisk DJ, Stoewsand GS. Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutr Cancer 1992;7:279-86
30. Amagase H, Schaffer E, Milner JA. Dietary components modify garlic's ability to suppress binding of 7,12-dimethylbenz(a)anthracene metabolites to rat mammary DNA. J Nutr 1996;126:817-24
31. Zoumas C, Amagase H, Milner JA. Impact of dietary lipid, protein and methionine on ability of garlic to decrease binding of 7,12 dimethylbenz(a)anthracene to mammary DNA. FASEB J 1992;6:A13
32. Wattenberg LW, Sparnins VL, Barany G, Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. Cancer Res 1989;49:2689-92
33. Choy YM, Kwok TT, Fung KP, Lee CY. Effect of garlic, Chinese medicinal drugs and amino acids on growth of Ehrlich ascites tumor cells in mice. Am J Chin Med 1983;11:69-73
34. Sundaram SG, Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett 1994;74:85-90
35. Sundaram SG, Milner JA. Diallyl disulfide inhibits the proliferation of human colon tumor cells in culture. Biochim Biophys Acta 1996;1315:15-20
36. Sundaram SG, Milner JA. Diallyl disulfide suppresses the growth of human colon tumor cell xenographs in athymic nude mice. J Nutr 1996;126:1355-61