Inhibition of human glutathione reductase by 10-arylisoalloxazines: Crystallographic, kinetic, and electrochemical studies

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1549-1554

  Schönleben Janas, Annette ^a   Kirsch, Peer ^b   Mittl, Peer R E ^c   Schirmer, R Heiner ^a   Rrauth Siegel, R Luise ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 CARBOXYMETHYL 10 (3,5 DICHLOROPHENYL)ISOALLOXAZINE; 3 CARBOXYMETHYL 10 (4 CHLOROPHENYL)ISOALLOXAZINE; ANTIMALARIAL AGENT; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; GLUTATHIONE REDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTALLOGRAPHY; DRUG SOLUBILITY; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MALARIA; OXIDATION REDUCTION REACTION;

ANTIMALARIALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; FLAVINS; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; KINETICS; MOLECULAR STRUCTURE; NADP; OXIDATION-REDUCTION; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029940171     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950511+     Document Type: Article

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