Mutation of the five conserved histidines in the endothelial nitric- oxide synthase hemoprotein domain. No evidence for a non-heme metal requirement for catalysis

Journal of Biological Chemistry

Volumn 274, Issue 31, 1999, Pages 21617-21624

  Rodríguez Crespo, Ignacio ^a   Nishida, Clinton R ^b   Knudsen, Giselle M ^b   Ortiz De Montellano, Paul R ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; HISTIDINE; IRON; NITRIC OXIDE SYNTHASE; ZINC;

ARTICLE; BINDING SITE; CATALYSIS; DIMERIZATION; ENDOTHELIUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CALMODULIN; CATALYSIS; CATTLE; CONSERVED SEQUENCE; EDETIC ACID; HEME; HEMEPROTEINS; HISTIDINE; HUMANS; IRON; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; ZINC;

EID: 0039702796     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.31.21617     Document Type: Article

References (31)

1. Griffith, O. W., and Stuehr, D. J. (1995) Annu. Rev. Physiol 57, 707-736
2. Knowles, R. G., and Moncada, S. (1994) Biochem. J. 298, 249-258
3. Masters, B. S., McMillan, K., Sheta, E. A., Nishimura, J. S., Roman, L. J., and Martasek, P. O. (1996) FASEB J. 10, 552-558
4. Marletta, M. A. (1994) Cell 78, 927-930
5. Bredt, D. S., and Snyder, S. H. (1994) Annu. Rev. Biochem. 63, 175-195
6. MacMicking, J., Xie, Q. W., and Nathan, C. (1997) Annu. Rev. Immunol. 15, 323-350
7. Pfeiffer S., Gorren, A. C., Pitters, E., Schmidt, K., Werner, E. R., and Mayer, B. (1997) Biochem. J. 328, 349-352
8. Mayer, B., Wu, C., Gorren, A. C., Pfeiffer, S., Schmidt, K., Clark, P., Stuehr, D. J., and Werner, E. R. (1997) Biochemistry 38, 8422-8427
9. Bec, N., Gorren, A. C., Voelker, C., Mayer, B., and Lange, R. (1998) J. Biol. Chem. 273, 13502-13508
10. Chen, D., and Frey, P. A. (1998) J. Biol. Chem. 273, 25594-25601
11. Goodwill, K. E., Sabatier, C., and Stevens, R. C. (1998) Biochemistry 37, 13437-13445
12. Hegg, E. L., and Que, L., Jr. (1997) Eur. J. Biochem. 250, 625-629
13. Perry, J. M., and Marletta, M. A. (1998) Proc. Natl. Acad. Sci. U. S. A 95, 11101-11106
14. Pirskanen, A., Kaimio, A.-M., Myllylä, R., and Kivirikko, K. I. (1996) J. Biol. Chem. 271, 9398-9402
15. Raman, C. S., Li, H., Martasek, P., Kral, V., Masters, B. S. S., and Poulos, T. (1998) Cell 95, 939-950
16. Fischmann, T. O., Hruza, A., Niu, X. D., Fossetta, J. D., Lunn, C. A., Dolphin, E., Prongay, A. J., Reichert, P., Lundell, D. J., Narula, S. K., and Weber, P. C. (1999) Nat. Struct. Biol. 6, 233-242
17. Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., and Tainer, J. A. (1998) Science 279, 2121-2126
18. Rodríguez-Crespo, I., Gerber, N. C., and Ortiz de Montellano, P. R. (1996) J. Biol. Chem. 271, 11462-11467
19. Rodríguez-Crespo, I., and Ortiz de Montellano, P. R. (1996) Arch. Biochem. Biophys. 336, 151-156
20. Hühmer, A. F. R., Nishida, C., Ortiz de Montellano, P. R., and Schöneich, C. (1997) Chem. Res. Toxicol. 10, 618-626
21. Siddhanta, U., Presta, A., Fan, B., Wolan, D., Rousseau, D. L., and Stuehr, D. J. (1998) J. Biol. Chem. 273, 18950-18958
22. Martásek, P., Liu, Q., Liu, J., Roman, L. J., Gross, S. S., Sessa, W. C., and Masters, B. S. S. (1996) Biochem. Biophys. Res. Commun. 219, 359-365
23. Persechini, A., McMillan, K., and Masters, B. S. S. (1995) Biochemistry 34, 15091-15095
24. Demura, Y., Ameshima, S., Ishizaki, T., Okamura, S., Miyamori, I., and Matsukawa, S. (1998) Free Radical Biol. Med. 26, 314-320
25. Martásek, P., Miller, R. T., Liu, Q., Roman, L. J., Salerno, J. C., Migita, C. T., Raman, C. S., Gross, S. S., Ikeda-Saito, M., and Masters, B. S. S. (1998) J. Biol. Chem. 273, 34799-34805
26. Boucher, J.-L., Genet, A., Vadon, S., Delaforge, M., Henry, Y., and Mansuy, D. (1992) Biochem. Biophys. Res. Commun. 187, 880-886
27. Boucher, J.-L., Genet, A., Vadon, S., Delaforge, M., and Mansuy, M. (1992) Biochem. Biophys. Res. Commun. 184, 1158-1164
28. Nagase, S., Takemura, K., Ueda, A., Hirayama, A., Aoyagi, K., Kondoh, M., and Koyama, A. (1997) Biochem. Biophys. Res. Commun. 233, 150-153
29. Sennequier, N., Boucher, J.-L., Battioni, P., and Mansuy, D. (1995) Tetrahedron Lett. 34, 6059-6062
30. Everett, S. A., Dennis, M. F., Patel, K. B., Stratford, M. E. L., and Wardman, P. (1996) Biochem. J. 317, 17-21
31. Venema, V. J., Ju, H., Zou, R., and Venema, R. C. (1997) J. Biol. Chem. 272, 28187-28190