Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase

Journal of Biological Chemistry

Volumn 274, Issue 35, 1999, Pages 24921-24929

  Reif, Andreas ^a   Fröhlich, Lothar G ^a   Kotsonis, Peter ^a   Frey, Armin ^a   Bömmel, Heike M ^a   Wink, David A ^b   Pfleiderer, Wolfgang ^c   Schmidt, Harald H H W ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BIOPTERIN; DIMER; MONOMER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PTERIDINE DERIVATIVE; TETRAHYDROBIOPTERIN;

AMINO ACID METABOLISM; ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME ISOLATION; ENZYME STABILITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; REACTION ANALYSIS; STOICHIOMETRY;

ARGININE; BIOPTERIN; DIMERIZATION; ENZYME STABILITY; ESCHERICHIA COLI; HUMANS; KINETICS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PROTEIN CONFORMATION; PTERIDINES; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SPERMINE;

EID: 0040205648     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.35.24921     Document Type: Article

References (60)

1. Schmidt, H. H. H. W., and Walter, U. (1994) Cell 78, 919-925
2. Adamson, D. C., Widemann, B., Sasaki, M., Glass, J. D., McArthur, J. C., Christov, V. I., Dawson, T. M., and Dawson, V. L. (1996) Science 274, 1917-1921
3. Schmidt, H. H. H. W., Warner, T. D., and Murad, F. (1992) Lancet 339, 986
4. Nathan, C., and Xie, Q. W. (1994) Cell 78, 915-918
5. Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U., and Murad, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 365-369
6. Bredt, D. S., Ferris, C. D., and Snyder, S. H. (1992) J. Biol. Chem. 267, 10976-10981
7. Masters, B. S. S., McMillan, K., Sheta, E. A., Nishimura, J. S., Roman, L. J., and Martasek, P. (1996) FASEB J. 10, 552-558
8. Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., and Snyder, S. H. (1991) Nature 351, 714-718
9. Griffith, O. W., and Stuehr, D. J. (1995) Annu. Rev. Physiol. 57, 707-736
10. Schmidt, H. H. H. W., Smith, R. M., Nakane, M., and Murad, F. (1992) Biochemistry 31, 3243-3249
11. Förstermann, U., and Kleinert, H. (1995) Naunyn-Schmiedeberg's Arch. Pharmacol. 352, 351-364
12. Crane, B. R., Arvai, A. S., Gachhui, R., Wu, C., Ghosh, D. K., Getzoff, E. D., Stuehr, D. J., and Tainer, J. A. (1997) Science 278, 425-431
13. Stuehr, D. J. (1997) Ann. Rev. Pharmacol. Toxicol. 37, 339-359
14. Tayeh, M. A., and Marletta, M. A. (1989) J. Biol. Chem. 264, 19654-19658
15. Kwon, N. S., Nathan, C. F., and Stuehr, D. J. (1989) J. Biol. Chem. 264, 20496-20501
16. Schmidt, H. H. H. W., Pollock, J. S., Förstermann, U., and Murad, F. (1991) FASEB J. 5, A1591
17. Kaufman, S. (1962) Proc. Natl. Acad. Sci. U. S. A. 5, 1085-1093
18. Marletta, M. A. (1993) J. Biol. Chem. 268, 12231-12234
19. McMillan, K., Bredt, D. S., Hirsch, D. J., Snyder, S. H., Clarke, J. E., and Masters, B. S. S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 11141-11145
20. Mayer, B., and Werner, E. R. (1995) Adv. Pharmacol. 34, 251-261
21. Giovanelli, J., Campos, K. L., and Kaufman, S. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 7091-7095
22. Bömmel, H. M., Reif, A., Fröhlich, L. G., Frey, A., Hofmann, H., Marecak, D. M., Groehn, V., Kotsonis, P., La, M., Köster, S., Meinecke, M., Bernhardt, M., Weeger, M., Ghisla, S., Prestwich, G. D., Pfleiderer, W., and Schmidt, H. H. H. W. (1998) J. Biol. Chem. 273, 33142-33149
23. Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., and Tainer, J. A. (1998) Science 279, 2121-2126
24. Raman, C. S., Li, H., Martasek, P., Kral, V., Masters, B. S. S., and Poulos, T. L. (1998) Cell 95, 939-950
25. Hofmann, H., and Schmidt, H. H. H. W. (1995) Biochemistry 34, 13443-13452
26. Griscavage, J. M., Fukotu, J. M., Komori, Y., and Ignarro, L. J. (1994) J. Biol. Chem. 269, 21644-21649
27. Hyun, J., Komori, Y., Chaudhuri, G., Ignarro, L. J., and Fukuto, J. M. (1995) Biochem. Biophys. Res. Commun. 206, 380-386
28. Abu-Soud, H., Wang, J., Rousseau, D., Fukoto, J., Ignarro, L., and Stuehr, D. (1995) J. Biol. Chem. 270, 22997-23006
29. Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R., and Mayer, B. (1994) J. Biol. Chem. 269, 13861-13866
30. Vasquez-Vivar, J., Kalyanaraman, B., Martasek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., and Pritchard, K. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9220-9225
31. Baek, K. J., Thiel, B. A., Lucas, S., and Stuehr, D. J. (1993) J. Biol. Chem. 268, 21120-21129
32. Klatt, P., Pfeiffer, S., List, B., Lehner, D., Glatter, O., Bächinger, H. P., Werner, E. R., Schmidt, K., and Mayer, B. (1996) J. Biol. Chem. 271, 7336-7342
33. Roman, L., Sheta, E., Martasek, P., Gross, S., and Liu, Q. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8428-8432
34. Presta, A., Siddhanta, U., Chaoqun, W., Sennequir, N., Huang, L., Abu-Soud, H., Erzurum, A., and Stuehr, D. J. (1997) Biochemistry 37, 298-310
35. Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bächinger, H. P., and Mayer, B. (1995) EMBO J. 14, 3687-3695
36. Wink, D., Feelisch, M., Fukuto, J., Chistodoulou, D., Jourd'heuil, D., Grisham, M., Vodovotz, Y., Cook, J., Krishna, M., DeGraff, W., Kim, S., Gamson, J., and Mitchell, J. (1998) Arch. Biochem. Biophys. 351, 66-74
37. Schmidt, H. H. H. W., Hofmann, H., Schindler, U., Shutenko, Z. S., Cunningham, D. D., and Feelisch, M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14492-14497
38. Schmidt, H. H. H. W., Pollock, J. S. P., Nakane, M., Förstermann, U., and Murad, F. (1992) Cell Calcium 13, 427-434
39. Sheta, E. A., McMillan, K., and Masters, B. S. S. (1994) J. Biol. Chem. 269, 15147-15153
40. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
41. Ogilvie, P., Schilling, K., Billingsley, M. L., and Schmidt, H. H. H. W. (1995) FASEB J. 9, 799-806
42. Pfeiffer, S., Gorren, A., Pitters, E., Schmidt, K., Werner, E., and Mayer, B. (1997) Biochem. J. 328, 349-352
43. Gachhui, R., Presta, A., Bentley, D. F., Abu-Soud, H. M., McArthur, R., Brudvig, G., Gosh, D. K., and Stuehr, D. J. (1996) J. Biol. Chem. 271, 20594-20602
44. Werner, E. R., Pitters, E., Schmidt, K., Wachter, H., Werner-Feldmayer, G., and Mayer, B. (1996) Biochem. J. 320, 193-196
45. Gorren, A. C. F., List, B. M., Schrammel, A., Pitters, E., Hemmens, B., Werner, E. R., Schmidt, K., and Mayer, B. (1996) Biochemistry 35, 16735-16745
46. Mayer, B., Klatt, P., Werner, E. R., and Schmidt, K. (1995) J. Biol. Chem. 270, 655-659
47. Xia, Y., and Zweier, J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12705-12710
48. Jaffrey, S. R., and Snyder, S. H. (1996) Science 274, 774-777
49. Hemmens, B., Woschitz, S., Pitters, E., Klosch, B., Volker, C., Schmidt, K., and Mayer, B. (1998) FEBS Lett. 430, 397-400
50. Narayanasami, R., Nishimura, J., McMillan, K., Roman, L., Shea, T., Robida, A., Horowitz, P., and Masters, B. S. S. (1997) Nitric Oxide Biol. Chem. 1, 39-49
51. Abu-Soud, H. M., Loftus, M., and Stuehr, D. J. (1995) Biochemistry 34, 11167-11175
52. Tzeng, E., Billiar, T. T., Robbins, P. D., Loftus, M., and Stuehr, D. J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11771-11775
53. Rodriguez-Crespo, I., Gerber, N. C., and Oritz de Montellano, P. R. (1996) J. Biol. Chem. 271, 11462-11467
54. Toth, M., Kukor, Z., and Sahin-Toth, M. (1997) Placenta 18, 189-196
55. Sahin-Toth, M., Kukor, Z., and Toth, M. (1997) Mol. Hum. Reprod. 3, 293-298
56. Hellermann, G., and Solomonson, L. (1997) J. Biol. Chem. 272, 12030-12034
57. Venema, R. C., Ju, H., Zou, R., Ryan, J. W., and Venema, V. J. (1997) J. Biol. Chem. 272, 1276-1282
58. List, B. M., Klatt, P., Werner, E. R., Schmidt, K., and Mayer, B. (1996) Biochem. J. 315, 57-63
59. Kaufman, S. (1993) Annu. Rev. Nutr. 13, 261-286
60. Xia, Y., and Zweier, J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6954-6958