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Reference 23 notes that arginine and various inhibitors of NOS all bind to the conserved active site carboxylate in a bidentate fashion, while NOHA bound to eNOS appears to interact with this carboxylate in a monodentate fashion. Further experiments are necessary, however, to clarify the details of NOHA binding by the various isoforms of NOS.
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2) values for all radical species described are between 0.75 and 0.78.
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34
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Both 10 and 11 are π-radicals.
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35
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