Regulation of apoptosis by tyrosine-containing domains of IL-4Rα: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis

Journal of Immunology

Volumn 161, Issue 2, 1998, Pages 859-867

  Zamorano, José ^a   Keegan, Achsah D ^a  

^a HOLLAND LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4 RECEPTOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHENYLALANINE; PHOSPHOPROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; RECEPTORS, INTERLEUKIN-2; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0032528425     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Paul, W. E. 1991. Interleukin 4: a prototypic immunoregulatory lymphokine. Blood 77:1859.
2. Ohara J., and W. E. Paul. 1988. Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression. Proc. Natl. Acad. Sci. USA 85:8221.
3. Noelle, R., P. H. Krammer, J. Ohara, J. W. Uhr, and E. S. Vitetta. 1984. Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor. Proc. Natl. Acad. Sci. USA 81:6149.
4. Stack, R. M., D. J. Lenschow, G. S. Gray, J. Bluestone, and F. W. Fitch. 1994. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J. Immunol. 152:5723.
5. Vitteta, E. S., J. Ohara, C. Myers, J. Layton, P. H. Krammer, and W. E. Paul. 1985. Serological, biochemical, and functional identity of B-cell stimulatory factor-1 and B cell differentiation factor for IgG1. J. Exp. Med. 162:1726.
6. Coffman, R. L., J. Ohara, M. W. Bond, J. Carty, A. Zlotnick, and W. E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538.
7. Oliver, K., R. J. Noelle, J. W. Uhr, P. H. Krammer, and E. S. Vitetta. 1985. B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth. Proc. Natl. Acad. Sci. USA 82:2465.
8. Rabin, E. M., J. O'Hara, and W. E. Paul. 1985. B cell stimulatory factor 1 activates resting B cells. Proc. Natl. Acad. Sci. USA 82:2935.
9. Paul, W. E., M. Brown, P. Hornbeck, J. Mizuguchi, J. O'Hara, E. Rabin, C. Snapper, and W. Tsang. 1987. Regulation of B-lymphocyte activation, proliferation, and differentiation. Ann. NY. Acad. Sci. 505:82-89.
10. Illera, V. A., C. E. Perandones, L. L. Stunz, D. A. Mower, and R. F. Ashman. 1993. Apoptosis in splenic B lymphocytes: regulation by protein kinase C and IL-4. J. Immunol. 151:2965.
11. Brunetti, M., N. Martelli, A. Colasante, M. Piantelli, P. Musiani, and F. B. Aiello. 1995. Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes. Blood 86:4199.
12. Parry, S. L., J. Hasbold, M. Holman, and G. G. Klaus. 1994. Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40. J. Immunol. 152:2821.
13. Foote L. C., R. G. Howard, A. Marshak-Rothstein, T. L. Rothstein. 1996. IL-4 induces Fas resistance in B cells. J. Immunol. 157:2749.
14. Nuñez, G., L. London, D. Hockenbery, M. Alexander, J. P. McKearn, and S. J. Korsmeyer. 1990. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 144:3602.
15. Dancescu, M., M. Rubio-Trujillo, G. Biron, D. Bron, G. Delespesse, and M. Sarfati. 1992. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and up-regulates Bcl-2 expression. J. Exp. Med. 176: 1319.
16. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Friedmann, A. Miyajima, R. K. Puri, W. E. Paul, and W. J. Leonard. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262:1880.
17. Miloux B., P. Laurent, O. Bonnin, J. Lupker, D. Caput, N. Vita, and P. Ferrara. 1997. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. FEBS Lett. 401:163.
18. Ihle, J. N. 1995. Cytokine receptor signaling. Nature 377:591.
19. O'Shea, J. J. 1997. Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7:1.
20. Keegan, A. D., J. A. Johnston, P. J. Tortolani, L. J. McReynolds, C. Kinzer, J. J. O'Shea, and W. E. Paul. 1995. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc. Natl. Acad. Sci. USA 92:7681.
21. Izuhara, K., and N. Harada. 1993. Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphalidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2. J. Biol. Chem. 268:13097.
22. Wang, L.-M., A. D. Keegan, W. E. Paul, M. A. Heidaran, J. S. Gutkind, and J. H. Pierce. 1992. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J. 11:4899.
23. Sun, X. J., L.-M. Wang, Y. Zhang, L. Yenush, M. G. Myers, E. Glasheen, W. S. Lane, J. H. Pierce, and M. F. White. 1995. Role of IRS-2 in insulin and cytokine signaling. Nature 377:173.
24. Crowley M. T., S. L. Harmer, and A. L. DeFranco. 1996. Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages. J. Biol. Chem. 271:1145.
25. Hou J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701.
26. Quelle F. W., K. Shimoda, W. Thierfelder, C. Fischer, A. Kim, S. M. Ruben, J. L. Cleveland, J. H. Pierce, A. D. Keegan, K. Nelms, W. E. Paul, and J. N. Ihle. 1995. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15:3336.
27. Mosley B., M. P. Beckmann, C. J. March, R. L. Idzerda, S. D. Gimpel, T. VandenBos, D. Friend, A. Alpert, D. Anderson, J. Jackson, J. M. Wignall, C. Smith, B. Gallis, J. E. Sims, D. Urdal, M. B. Widmer, D. Cosman, and L. S. Park. 1989. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59:335.
28. Harada N., B. E. Castle, D. M. Gorman, N. Itoh, J. Schreurs, R. L. Barrett, M. Howard, and A. Miyajima. 1990. Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding. Proc. Natl. Acad. Sci. USA 87:857.
29. Galizzi J. P., C. E. Zuber, N. Harada, D. M. Gorman, O. Djossou, R. Kastelein, J. Banchereau, M. Howard, and A. Miyajima. 1990. Molecular cloning of a cDNA encoding the human interleukin 4 receptor. Int. Immunol. 2:669.
30. Richter, G., G. Hein, T. Blankenstein, and T. Diamantstein. 1995. The rat interleukin 4 receptor: coevolution of ligand and receptor. Cytokine 7:237.
31. Keegan, A. D., K. Nelms, M. White, L.-M. Wang, J. H. Pierce, and W. E. Paul. 1994. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 76:811.
32. Wang, H. Y., W. E. Paul, and A. D. Keegan. 1996. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor α chain. Immunity 4:113.
33. Pernis, A., B. Witthuhn, A. D. Keegan, K. Nelms, E. Garfein, J. N. Ihle, W. E. Paul, J. H. Pierce, and P. Rothman. 1995. Interleukin 4 signals through two related pathways. Proc. Natl. Acad. Sci. USA 92:7971.
34. Ryan, J. J., L. J. McReynolds, A. Keegan, L.-H. Wang, E. Garfein, P. Rothman, K. Nelms, and W. E. Paul. 1996. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 4:123.
35. Zamorano, J., H. Y. Wang, L.-M. Wang, J. H. Pierce, and A. D. Keegan. 1996. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J. Immunol. 157:4926.
36. Ohara, J., J. E. Coligan, K. Zoon, W. L. Maloy, and W. E. Paul. 1987. High-efficiency purification and chemical characterization of B cell stimulatory factor-1/interleukin 4. J. Immunol. 139:1127.
37. Wolf, G., T. Trub, E. Ottinger, L. Groninga, A. Lynch, M. F. White, M. Miyazaki, J. Lee, and S. E. Shoelson. 1995. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J. Biol. Chem. 270:27407.
38. Zhou M. M., B. Huang, E. T. Olejniczak, R. P. Meadows, S. B. Shuker, M. Miyazaki, T. Trub, S. E. Shoelson, and S. W. Fesik. 1996. Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat. Struct. Biol. 3:388.
39. Scharenberg, A. M., and J.-P. Kinet. 1997. The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? Cell 87:961.
40. Muta T., T. Kurosaki, Z. Misulovin, M. Sanchez, M. C. Nussenzweig, and J. V. Ravetch. 1994. A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signaling. Nature 368:70.
41. D'Ambrosio D., K. L. Hippen, S. A. Minskoff, I. Mellman, G. Pani, K. A. Siminovitch, and J. C. Cambier. 1995. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science 268:293.
42. Ono M., S. Bolland, P. Tempst, and J. V. Ravetch. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 383:263.
43. Damen, J. E., L. Liu, P. Rosten, R. K. Humphries, A. B. Jefferson, P. W. Majerus, and G. Krystal. 1996. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc. Natl. Acad. Sci. USA 93:1689.
44. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S.-I. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of STAT6 in IL-4 signaling. Nature 380:627.
45. Shimoda, K., J. V. Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted STAT6 gene. Nature 380:630.
46. Izuhara K., R. A. Feldman, P. Greer, N. Harada. 1996. Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase. Blood 88:3910.
47. Zamorano, J., H. Y. Wang, R. Wang, Y. Shi, G. D. Longmore, and A. D. Keegan. 1998. Regulation of cell growth by IL-2: role of STATS in protection from apoptosis but not in cell cycle progression. J. Immunol. 160:3502.