The DNA dependent protein kinase: A major protein involved in the cellular response to ionizing radiation;La proteine kinase dependante de l'ADN (DNA-PK): Une proteine majeure de la reponse cellulaire aux radiations ionisantes

Bulletin du Cancer

Volumn 86, Issue 12, 1999, Pages 977-983

  Muller, Catherine ^a   Rodrigo, Gregory ^a   Calsou, Patrick ^a   Salles, Bernard ^a  

^a CNRS UPR 9062   (France)

Author keywords

DNA PK; Double strand break; Ionizing radiation; Ku; Radiosensitivity

Indexed keywords

CELL DNA; DNA DEPENDENT PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

CANCER RADIOTHERAPY; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; IONIZING RADIATION; MOLECULAR DYNAMICS; PROTEIN DNA BINDING; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIVITY; REVIEW; TREATMENT OUTCOME; DNA DAMAGE; DRUG RESISTANCE; GENETICS; METABOLISM; PHENOTYPE; RADIATION DOSE;

DNA DAMAGE; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; HUMANS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE;

EID: 0033370797     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. 1. Jeggo PA. DNA breakage and repair. Adv Gen 1998; 38 : 185-218.
2. 2. Tsukamato Y, Ikeda Y. Double strand break repair mediated by DNA end-joining. Genes to Cells 1998; 3 : 135-44.
3. 3. Smith GC, Jackson SP. The DNA dependent protein kinase. Genes Dev 1999; 13 : 916-34.
4. 4. Gottlieb TM, Jackson SP. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 1993; 72 : 131-42.
5. 5. Minori T, Akizuki H, Yamagata S, Inada S, Yoshida ?, Homma M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap syndrome. J Clin Invest 1981; 68 : 611-20.
6. 6. Falzon M, Fewell JW, Kuff EL. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single-to double-strand transitions in DNA. J Biol Chem 1993; 268 : 10546-52.
7. 7. Wu X, Lieber MR. Protein-protein and protein DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol Cell Biol 1996; 16 : 5186-93.
8. 8. Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA, Jackson SP. DNA-dependent kinase activity is absent in xrs6 cells: implications for site specific recombination and DNA double strand break repair. Proc Natl Acad Sci USA 1995; 92 : 320-4.
9. 9. Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995; 82 : 849-56.
10. 10. Anderson CW, Connelly MA, Zhang H, Sipley JD, Leesmiller SP, Sakaguchi K, et al. The human DNA-activated protein kinase, DNA-PK, is activated by DNA breaks and phosphorylates nuclear DNA-binding protein substrates on serines and threonines following by glutamine. J Protein Chem 1994; 13 : 500-1.
11. 11. Zdzienicka MZ. Mammalian X-ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation. Cancer Surv 1996; 28 : 281-93.
12. 12. Etrami A, Smider V, Rathmell WK, He DM, Hendrickson EA, Zdzienicka M, Chu G. Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Mol Cell Biol 1996; 16 : 1519-26.
13. 13. Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, Jackson SP, Jeggo PA. Identification of a nonsense mutation in the carboxy-terminal region of DNA-dependent protein kinase catalytic sub-unit in the scid mouse. Proc Natl Acad Sci USA 1996; 93 : 10285-90.
14. 14. Leber R, Wise TW, Mizuta R, Meek K. The XRCC4 product is a target for and interacts with the DNA-dependent protein kinase. J Biol Chem 1998; 273 : 1794-801.
15. 15. Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, et al. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 1994; 265 : 1442-5.
16. 16. Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 1995; 80 : 813-23.
17. 17. Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient mice exhibits severe combined immunodeficiency and defective processive of V(D)J recombination intermediates. Cell 1996; 86 : 379-89.
18. 18. Gao YJ, Chauduri J, Zhu CM, Davidson L, Weawer DT, Alt FW. A targeted DNA-PK null mutation reveals DNA-PK independent functions for Ku in V(D)J recombination. Immunity 1998; 9 : 367-76.
19. 19. Gu YS, Seidl KJ, Rathbun GA, Zhu CM, Manis JP, VanderStoep N, et al. Growth retardation and leaky SCID phenotype of Ku70 deficient mice. Immunity 1997; 7 : 653-65.
20. 20. Ramsden DA, VanGent DC, Gellert M. Specificity in V(D)J recombination: new lessons from biochemistry and genetics. Curr Opin Immunol 1997; 9 : 114-20.
21. 21. Lee SE, Mitchell RA, Cheng A, Hendrickson EA. Evidence for DNA-PK-dependent and -independent pathways in mammalian cells as a function of the cell cycle. Mol Cell Biol 1997; 17 : 1425-33.
22. 22. Ramsden DA, Gellert M. Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J 1998; 17 : 609-14.
23. 23. Caldecott K, Jeggo P. Cross sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutat Res 1991; 255 : 111-21.
24. 24. Tanaka T, Yamagami T, Oka Y, Nomura T, Sugiyama H. The scid mutation causes defect in the repair system for both double-strand DNA breaks and DNA cross-links. Mutat Res 1993; 288 : 277-80.
25. 25. Muller C, Calsou P, Frit P, Cayrol C, Carter T, Salles B. UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase (DNA-PK) mutant cells. Nucleic Acids Res 1998; 26 : 1382-9.
26. 26. Marangoni E, Le Romancer M, Foray N, Muller C, Douck-Rasy D, Barrois M, et al. Transfer of Ku86 RNA antisens decreases the radioresistance of human fibroblasts. Cancer Gene Therapy (sous presse).
27. 27. Kurisama A, Kumano S, Boubnov NV, Story MD, Tung CS, Peterson SR, Chen DJ. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol 1999; 19 : 3877-84.
28. 28. Wymann MP, Bulgarelli-Leva G, Zvebelil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD, Panayotou G, Wortmannin inactivates phosphoinositide 3-kinase by covalent modifications of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol 1996; 16 : 1722-33.
29. 29. Sarkaria JN, Tibbets RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res 1998; 58 : 4375-82.
30. 30. Izzard RA, Jackson SP, Smith GC. Competitive and non-competitive inhibition of the DNA-dependent protein kinase. Cancer Res 1999; 59 : 2581-6.
31. 31. Rossenweig K, Youmell MB, Palayoor ST. Radiosensitization of human tumor cells by the phosphatidyl 3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res 1997; 3 : 1149-56.
32. 32. Price BD, Youmell MB. The phosphatidyl 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res 1996; 56 : 246-50.
33. 33. Boulton S, Kyle S, Yalcintepe L, Durkacz BW. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in chinese ovary cells. Carcinogenesis 1996; 17 : 2285-90.
34. 34. Chernokova SB, Wells RL, Elkind MM. Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat Res 1999; 151 : 159-66.
35. 35. Kruszewski M, Wojewodzka M, Iwanenko T, Szumiel L, Okuyama A. Differential inhibitory effect of OK-1035 on DNA repair in L5178Y murine lymphoma sublines with functional and defective repair of double strand breaks. Mutat Res 1998; 409 : 31-6.
36. 36. Sirzen F, Nillson A, Zhivotovsky B, Lewensohn R. DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity. Eur J Cancer 1999; 35 : 111-6.
37. 37. Allanis-Turner MJ, Lintott LG, Barron GM, Day RS, Lees-Miller SP. Lack of correlation between DNA-dependent protein kinase activity and tumor radiosensitivity. Cancer Res 1995; 55 : 5200-2.
38. 38. Cai QQ, Plet AA, Imbert J, Lafagepochitaloff M, Cerdan C, Blanchard JM. Chromosomal location and expression of the genes coding for Ku p70 and Ku p80 in human cell lines and normal tisues. Cytogen Cell Genet 1994; 65 : 221-7.
39. 39. Moll U, Lau R, Sypes MA, Gupta MM, Anderson CW. DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant tissues. Oncogene 1999; 18 : 3114-26.
40. 40. Frit P, Canitrot Y, Muller C, Foray N, Calsou P, Marangoni E, et al. Cross-resistance to ionizing radiation in a murine leukemic cell line resistant to cisplatin: role of Ku autoantigen. Molecular Pharmacology (sous presse).
41. 41. Muller C, Christodoulopoulos G, Salles B, Panasci L. DNA-dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia (CLL) lymphocytes to nitrogen mustards. Blood 1998; 92 : 2213-9.
42. 42. Christodoulopoulos G, Muller C, Salles B, Panasci L. Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-PK activity using wortmannin. Cancer Res 1998; 58 : 1789-92.
43. 43. Muller C, Calsou P, Frit P, Salles B. Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eucaryotic cells. Biochimie 1999; 81 : 117-26.