Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines

Cancer Research

Volumn 56, Issue 16, 1996, Pages 3796-3802

  Bestilny, Leslie J ^a   Brown, Christopher B ^a   Miura, Yutaka ^a   Robertson, Laurie D ^a   Riabowol, Karl T ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; DIMETHYL SULFOXIDE; ENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; RNA; TELOMERASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC CELL; TELOMERE;

ANIMALS; CELL DIFFERENTIATION; DIMETHYL SULFOXIDE; DNA; HL-60 CELLS; HUMANS; MICE; TELOMERASE; TETRADECANOYLPHORBOL ACETATE; TRETINOIN;

EID: 0029761161     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Morin, G B The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats Cell. 49: 521-529, 1989.
2. Moyzis, R. K., Buckingham, J. M., Cram, L S., Dani, M., Deaven, L L , Jones, M. D , Meyne, J., Ratliff, R L , and Wu, J-R A A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes Proc. Natl Acad. Sci. USA, 85 6622-6626, 1988.
3. Rhyu, M. S. Telomeres, telomerase, and immortality J. Natl. Cancer Inst , 87: 884-894, 1995.
4. Harley, C. B. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res., 256: 271-282, 1991
5. Olovnikov, A M. A theory of marginotomy. J. Theor Biol., 41: 181-190, 1973
6. Allsopp, R. C , Vaziri, H., Patterson, C , Goldstain, S., Younglai, E. V., Futcher, A. B., Greider, C. W., and Harley, C. B. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad. Sci. USA, 89: 10114-10118, 1992.
7. Harley, C B., Futcher, A. B , and Greider, C. W. Telomeres shorten during aging of human fibroblasts Nature (Lond.), 345: 458-460, 1990.
8. Kim, N W., Piatyszek, M A., Prowse, K R., Harley, C. B , West, M D., Ho, P L C., Coviello, G. M., Wright, W E , Weinrich, S. L., and Shay, J. W Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
9. Counter, C. M , Avilion, A. A , LeFeuvre, C. E , Stewart, N. G., Greider, C W., Harley, C. B , and Bacchetti, S Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 11: 1921-1929, 1992
10. Wright, W. E , and Shay, J. W. Telomere positional effects and the regulation of cellular senescence. Trends Genet, 8 193-197, 1992.
11. Bacchetti, S., Counter, C. M., Chadeneau, K. C., Gupta, J., Harley, C. B., Leber, B , Gallinger, S., Hirte, H W., Siegel, P , and Muller, W. J. Telomerase activity in human and murine somatic tissues and tumors. Proc. Am. Assoc. Cancer Res., 36: 674, 1995.
12. Prowse, K. R., and Greider, C. W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA, 92: 4818-4822, 1995.
13. Kipling, D., and Cooke, H J. Hypervariable ultra-long telomeres in mice. Nature (Lond), 347: 400-402, 1990.
14. Starling, J. A., Maule, J., Hastie, N. D , and Allshire, R. C. Extensive telomere repeat arrays in mouse are hypervariable Nucleic Acids Res , 18: 6881-6888, 1990.
15. McCormick, A., and Campisi, J. Cellular aging and senescence. Curr. Opin Cell Biol , 3: 230-234, 1991.
16. Collins, S J. The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression Blood, 70: 1233-1244, 1987.
17. Strickland, S , Smith, K K., and Mariotti, K. R. Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP. Cell, 21: 347-355, 1980
18. Jones-Villeneuve, E. M. V , McBurney, M. W., Rogers, K A., and Kalnins, V I. Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells J. Cell Biol , 94: 253-262, 1982
19. Shea, T. B., Fischer, I., and Sapirstein, V. S. Effect of retinoic acid on growth and morphological differentiation of mouse NB2a neuroblastoma cells in culture. Dev. Brain Res , 21: 307-314, 1985
20. Silberstein, L , Webster, S. G , Trivis, M., and Blau, H. M Developmental progression of myosin gene expression in cultured muscle cells. Cell, 46: 1075-1081, 1986
21. Newberger, P., Chovaniec, M., Greenberger, J., and Cohen, H. Functional changes in human leukemic cell line HL-60 a model for myeloid differentiation. J. Cell Biol , 82: 315-322, 1979.
22. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidimum thiocyanate-phenol-chloroform extraction. Anal. Biochem , 162: 156, 1987.
23. Wong, H , Anderson, W. D., and Riabowol, K. T. Monitoring mRNA expression by PCR: the "primer-dropping" method. Anal. Biochem., 223: 251-258, 1994
24. Feng, J , Funk, W D., Wang, S., Weinrich, S. L., Avilion, A. A , Chiu, C., Adams, R. R., Chang, E , Allsopp, R. C , Yu, J., Le, S., West, M. D., Harley, C. B., Andrews, W H., Greider, C. W., and Villeponteau, B The RNA component of human telomerase Science (Washington DC), 269: 1236-1241, 1995.
25. Nicoletti, I., Migliorati, G., Pagliacci, M C., Grignani, F., and Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol. Methods, 139: 271-279, 1991.
26. Yu, G-L., Bradley, J. D., Attardi, L. D., and Blackburn, E H In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (Lond.), 344: 126-131, 1990.
27. Greider, C. W , and Blackburn, E. H. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (Lond.), 337: 331-337, 1989.
28. Shippen-Lentz, D., and Blackburn, E. H. Functional evidence for an RNA template in telomerase. Science (Washington DC), 247: 546-552, 1990.
29. Lingner, J., Hendrick, L. L., and Cech, T. R. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev., 8 1984-1998, 1994
30. Blasco, M. A., Funk, W., Villeponteau, B . and Greider, C. W. Functional characterization and developmental regulation of mouse telomerase RNA. Science (Washington DC), 269: 1267-1270, 1995.
31. 1 arrest. J. Clin. Invest., 89: 954-960, 1992.
32. Martin, S J., Bradley, J. G., and Cotter, T G. HL-60 cells induced to differentiate toward neutrophils subsequently die via apoptosis Clin Exp. Immunol., 79: 448-453, 1990.
33. Darzynkiewicz, S B., Del Bino, G., Gorczjca, W., Hotz, M A., Lassota, P., and Traganos, F. Features of apoptotic cells measured by flow cytometry. Cytometry, 13: 795-808, 1992
34. Sharma, H W , Sokoloski, J. A , Perez, J. R , Maltese, J. Y., Sartorelli, A C., Stein, C. A , Nichols, G., Khaled, Z, Telang, N T , and Narayanan, R Differentiation of immortal cells inhibits telomerase activity. Proc. Natl. Acad. Sci. USA, 92: 12343-12346, 1995.