Clonality and stability of the p53 gene in human astrocytic tumor cells: Quantitative analysis of p53 gene mutations by yeast functional assay

International Journal of Cancer

Volumn 67, Issue 3, 1996, Pages 447-450

  Tada, Mitsuhiro ^a   Iggo, Richard D ^b   Ishii, Nobuaki ^a   Shinohe, Yumiko ^a   Sakuma, Shirou ^a   Estreicher, Anne ^b   Sawamura, Yutaka ^a   Abe, Hiroshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ALLELE; ARTICLE; ASTROCYTOMA; CARCINOGENESIS; CELL CLONE; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; NERVE FIBER GROWTH; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ASTROCYTOMA; BASE SEQUENCE; BRAIN NEOPLASMS; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; GENES, P53; GLIOBLASTOMA; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; SACCHAROMYCES CEREVISIAE; TUMOR CELLS, CULTURED;

EID: 0029808229     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960729)67:3<447::AID-IJC22>3.0.CO;2-3     Document Type: Article

References (14)

1. FLAMAN, J.-M., FREBOURG, T., MOREAU, V., CHARBONNIER, F., MARTIN, C., CHAPPUIS, P., SAPPINO, A.-P., LIMACHER, J.-M., BRONS, L., BENHATTAR, J., TADA, M., VAN MEIR, E.G., ESTREICHER, A. and IGGO, R.D., A simple p53 functional assay for screening cell lines, blood, and tumors. Proc. nat. Acad. Sci. (Wash.), 92, 3963-3967 (1995).
2. FLAMAN, J.-M., FREBOURG, T., MOREAU, V., CHARBONNIER, F., MARTIN, C., ISHIOKA, C., FRIEND, S.H. and IGGO, R., A rapid PCR fidelity assay. Nucleic Acids Res., 22, 3259-3260 (1994).
3. FORRESTER, K., LUPOLD S.E., OTT, V.L., CHAY, C.H., BAND, V., WANG. X.W. and HARRIS, C.C., Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent. Oncogene, 10, 2103-2111 (1995).
4. FRANKEL, R.H., BAYONA, W., KOSLOW, M. and NEWCOMB, E.W., p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. Cancer Res., 52, 1427-1433 (1992).
5. FRIEND, S., p53: a glimpse at the puppet behind the shadow play. Science, 265, 334-335 (1994).
6. FUITS, D., BROCKMEYER, D., TULLOUS, M.W., PEDONE, C.A. and CAWTHORN, R.M., p53 mutation and loss of heterozygosity on chromosome 17 and 10 during astrocytoma progression. Cancer Res., 52, 674-679 (1992).
7. HAYASHI, Y., YAMASHITA, J. and YAMAGUCHI, K., Timing and role of p53 gene mutation in the recurrence of glioma. Biochem. biophys. Res. Comm., 180, 1145-1150 (1991).
8. LOUIS, D.N., The p53 gene and protein in human brain tumors. J. Neuropathol. exp. Neurol, 53, 11-21 (1994).
9. MERCER, W.E., SHIELDS, M.T., AMIN, M., SAUVE, G.J., APPELLA, E., ROMANO, J.W. and ULLRICH, S.J., Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc. nat. Acad. Sci. (Wash.), 87, 6166-6170 (1990).
10. SIDRANSKY, D., MIKKELSEN, T., SCHWECHHEIMER, K., ROSENBLUM, M.L., CAVENEE, W. and VOGELSTEIN, B., Clonal expansion of p53 mutant cells is associated with brain tumor progression. Nature (Land.), 355, 846-847 (1992).
11. UEBA, T., NOSAKA, T., TAKAHASHI, J.A., SHIBATA, F., FLORKIEWICZ, R.Z., VOGELSTEIN, B., ODA, Y., KIKUCHI, H. and HATANAKA, M., Transcriptional regulation of the basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. Proc. nat. Acad. Sci. (Wash.), 91, 9009-9013 (1994).
12. VAN MEIR, E.G., KIKUCHI, T., TADA, M., LI, H., DISERENS, A.-C., WOJCIK, B.E., HUANG, H.-J.S., FRIEDMANN, T., DE TRIBOLET, N. and CAVENEE, W.K., Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res., 54, 649-652 (1994a).
13. VAN MEIR, E.G., POLVERINI, P.J., CHAZIN, V.R., SU HUANG, H.J., DE TRIBOLET, N. and CAVENEE, W.K., Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature (Genet.). 8, 171-176 (1994b).
14. YAHANDA. A.M., BRUNER, J.M., DONEHOWER, L.A. and MORRISON, R.S., Astrocytes derived from p53-deficient mice provide a multistep in vitro model for development of malignant gliomas. Mol. cell. Biol., 15, 4249-4259 (1995).