Inhibitors of 5-lipoxygenase: A therapeutic potential yet to be fully realized?

European Journal of Medicinal Chemistry

Volumn 34, Issue 9, 1999, Pages 671-685

  Young, Robert N ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

5 Lipoxygenase; 5 lipoxygenase activating protein; Asthma; Inflammation; Inhibitor

Indexed keywords

1 ETHYL 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 2 QUINOLONE; 2 CYANO 7 [3 FLUORO 5 (3 HYDROXY 6,8 DIOXABICYCLO[3.2.1]OCT 3 YL)PHENOXYMETHYL] 4 (3 FURYL)QUINOLINE; 2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; 3 [1 (4 HYDROXY 3 IODOBENZYL) 5 ISOPROPYL 3 (4 TRIAZENOPHENYLSULFONYL) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [6 [7 CYANO 5 (3 FURYL) 2 NAPHTHOXYMETHYL] 2 PYRIDYL] 3 HYDROXY 6,8 DIOXABICYCLO[3.2.1]OCTANE; 4 BROMO 2,7 DIMETHOXY 3H PHENOTHIAZIN 3 ONE; 4 CHLORO 3H PHENOTHIAZIN 3 ONE; 6 HYDROXY 5,7 DIMETHYL 2 METHYLAMINO 4 (3 PYRIDYLMETHYL)BENZOTHIAZOLE; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; ATRELEUTON; BAY Y 1015; FENLEUTON; L 674636; L 689065; L 691816; L 697198; L 699333; L 708780; LICOFELONE; LIPOXYGENASE INHIBITOR; MONTELUKAST; N [5 (4 FLUOROPHENOXY) 2 THIENYL]METHANESULFONAMIDE; TEPOXALIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZAFIRLUKAST; ZILEUTON;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; CLINICAL TRIAL; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; ICOSANOID METABOLISM; INFLAMMATION; NONHUMAN; REVIEW;

EID: 0032881884     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)00225-1     Document Type: Review

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