Pharmacological profile of the novel potent antirheumatic (4-(2',4'- difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 5, 1997, Pages 648-652

  Panajotova, Vladimira ^a,b   Anděrová, Eva ^a   Jandera, Antonín ^a   Kuchař, Miroslav ^a  

^a VÚFB a s   (Czech Republic)

^b Research Institute of Pharmacy and Biochemistry Prague   (Czech Republic)

Author keywords

(4 (2'.4' Difluorobiphenyl 4 yl) 2 methyl 4 oxobutanoic acid; Antiarthritic drugs; CAS 112344 52 2; VUFB 16066, pharmacological profile

Indexed keywords

ANTIRHEUMATIC AGENT; DICLOFENAC; FENBUFEN; FLOBUFEN; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; IMMUNOMODULATION; INFLAMMATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PERITONEUM CELL; PHAGOCYTOSIS;

ABDOMINAL PAIN; ACETIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; ARTHRITIS, EXPERIMENTAL; BUTYRIC ACIDS; CARRAGEENAN; DICLOFENAC; DINOPROSTONE; EDEMA; FEMALE; GRAFT VS HOST REACTION; LEUKOTRIENE B4; MALE; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PHENYLBUTYRATES; PLEURISY; RATS; RATS, INBRED LEW; STOMACH ULCER;

EID: 0031007466     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Williams, K. M., Day, R. O., Breit, S. N., Adv. Drug Res. 24, 121 (1993)
2. Vane, J., Drugs 33 (Suppl. 1), 18 (1987)
3. Szabo, S., Spill, W. F., Rainsford, K. D., Med. Toxicol. 4, 77 (1989)
4. Lewis, A. J., Glaser, K. B., Sturm, R. J. et al., Int. J. Immunopharmacol. 14, 497 (1992)
5. Vane, J. R., Botting, R. M., Inflamm. Res. 44, 1 (1995)
6. Lewis, A. J., Keft, A. F., Immunopharmacol. Immunotoxicol. 17 (4), 607 (1995)
7. Keppler, D., Rev. Physiol. Biochem. Pharmacol. 121, 1 (1992)
8. Kuchař, M., Brůnová, B., Rejholec, V. et al., Coll. Czech. Chem. Commun. 51, 2617 (1986)
9. Kuchař, M., Brůnová, B., Grimová, J. et al., Czech. 243, 570 (1986), US 4,683331 (1987)
10. Kuchař, M., Maturová, E., Brůnová, B. et al., Coll. Czech. Chem. Commun. 53, 1862 (1988)
11. Chiccarelli, F. S., Eisner, H. J., van Lear, G. E., Arzneim.-Forsch./Drug Res. 30(I), 407 (1980)
12. Kuchař, M., Rejholec, V., Roubal, Z. et al., in: QSAR in Drug Design and Toxicology, D. Hadži, B. Jerman-Blažič (eds.), p. 124, Elsevier, Amsterdam (1987)
13. Lapka, R., Šmolík, S., Rejholec, V., Drug Metab. Dispos. 18, 1060 (1990)
14. Winter, C. A., Risley, E. A., Nuss, G. W., Proc. Soc. Exp. Biol. Med. 111, 544 (1962)
15. Di Rosa, M., J. Pharm. Pharmacol. 24, 89 (1972)
16. Almeida, R. P., Bayer, M. B., Horakova, Z. et al., J. Pharmacol. Exp. Ther. 214, 74 (1980)
17. Hidaka, T., Hosoe, K., Katsumi, I. et al., J. Pharm. Pharmacol. 38, 242 (1986)
18. Opas, E. E., Bonney, R. J., Humes, J. L., J. Invest. Dermatol. 84, 253 (1985)
19. Pearson, C. M., Wood, F. D., Arthritis Rheum. 2, 440 (1959)
20. Taurog, J. D., Argentieri, D. C., McReynolds, R. A., Methods Enzymol. 162, 339 (1988)
21. Bradley, L. M., in: Selected Methods in Cellular Immunology, B. B. Mishell, S. M. Shiigi (eds.), p. 156, W. H. Freeman and Company, New York (1980)
22. Amanuma, F., Wakaumi, C., Tanaka, M. et al., Folia Pharmacol. Japon. 84, 543 (1984)
23. Palmer, R. M. J., Salmon, J. A., Immunology 50, 65 (1983)
24. Twist, V. W., Barne, R. D., Transplantation 15, 183 (1973)
25. Větvička, V., Fornůsek, L., Kopeček, J. et al., Immunol. Lett. 5, 97 (1982)
26. McMillan, R. M., Foster, S. J., Shaw, J. S., in: Mechanisms and Models in Rheumatoid Arthritis, B. Henderson, J. C. W. Edwards, E. R. Pettipher (eds.), p. 283, Academic Press, New York (1995)
27. Klareskog, L., in: Immunopharmacology in Autoimmune Diseases and Transplantation, H. E. Rugstad (ed.), p. 369, Plenum Press, New York (1992)
28. Lipsky, P. E., Davis, L. S., Cush, J. J. et al., Springer Semin. Immunopathol. 11, 123 (1989)
29. Sugita, T., Furukawa, O., Ueno, M. et al., Int. J. Immunopharrnacol. 15, 469 (1993)
30. France, L., Velo, G. P., Inflamm. Res. 44(3), 139 (1995)