Lipidosis Induced in the Dog Gallbladder by a Direct 5-Lipoxygenase Inhibitor

Toxicologic Pathology

Volumn 24, Issue 2, 1996, Pages 231-237

  Molon Noblot, Sylvain ^a   Gillet, Jean Pierre ^a   Durand Cavagna, Geneviève ^a   Huber, Anna C ^a   Patrick, Darryl H ^a   Duprat, Pierre ^a  

^a Dohme Chibret Centre de Recherche Riom   (France)

Author keywords

Anti inflammatory; drug induced; electron microscopy; histopathology; lipids accumulation

Indexed keywords

3 [6 [7 CYANO 5 (3 FURYL) 2 NAPHTHOXYMETHYL] 2 PYRIDYL] 3 HYDROXY 6,8 DIOXABICYCLO[3.2.1]OCTANE; CHOLESTEROL; FAT DROPLET; LIPOXYGENASE INHIBITOR; MYELIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL VACUOLE; CONTROLLED STUDY; DOG; FEMALE; FOAM CELL; GALLBLADDER DISEASE; GALLBLADDER MUCOSA; HISTOPATHOLOGY; LIPIDOSIS; MACROPHAGE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHAGOSOME; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BICYCLO COMPOUNDS; DOGS; FEMALE; GALLBLADDER; GALLBLADDER DISEASES; LIPIDOSES; LIPOXYGENASE INHIBITORS; MALE; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; QUINOLINES;

ANIMALIA; CANIS FAMILIARIS;

EID: 0029972553     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400211     Document Type: Article

References (36)

1. Committee of Care and Use of Laboratory Animals (1985). Guide for the Care and Use of Laboratory Animals. NIH Publication No. 86-23, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, National Institutes of Health, Public Health Services, U.S. Department of Health and Human Services, Washington, D.C.
2. Conter RL, Roselin JL, Porter Fink V., and Den Besten L. (1986). Gallbladder absorption increases during early cholesterol gallstone formation. Am. J. Surg. 151: 184-191.
3. English M. and Hopwood D. (1985). Lipid in the human gallbladder mucosa. A histochemical study by light and electron microscopy. J. Pathol. 146: 333-336.
4. Evett RD, Higgins JA, and Brown AL (1964). The fine structure of normal mucosa in human gallbladder. Gastroenterology 47: 49-71.
5. Ferreira SH (1979). Chemical Messengers of the Inflammatory Response, JC Houck (ed). Elsevier Biomedical Press, Amsterdam, p. 113.
6. Girard Y., Delorme D., Rejean F., Dube D., Hamel P., Lepine C., and Ducharme Y. (1994). Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis. U.S. Patent, Patent No. 5,308,852, May 3.
7. Girard Y., Hamel P., Delorme D., Dubé D., Ducharme Y., Fortin R., Lépine C., Young RN, Gresser M., Riendeau D., Chan C., Jones T., Tagari P., and Ford-Hutchinson AW (1994). Dioxabicyclooctanyl naphthalenes as selective, non-redox and orally active 5-lipoxygenase inhibitors. 9th International Conference on Prostaglandins and Related Compounds, Florence, Italy, June 6-10.
8. Fox H. (1972). Ultrastructure of the human gallbladder epithelium in cholelithiasis and chronic cholecystitis. J. Pathol. 108: 157-164.
9. Hayward AF (1962). Aspects of the fine structure of the gallbladder epithelium of the mouse. J. Anat. London 96(2): 227-236.
10. Hayward AF (1966). An electron microscopic study of the developing gallbladder epithelium in the rabbit. J. Anat. 100: 245.
11. Hayward AF (1968). The structure of gallbladder epithelium. Int. Rev. Gen. Exp. Zool. 3: 205-239.
12. Holzbach RT, Marsh M., Olzewski M., and Holan K. (1973). Cholesterol solubility in bile: Evidence that supersaturated bile is frequent in healthy man. J. Clin. Invest. 52: 1467-1476.
13. Hopwood D., Kouroumalis E., Milne G., and Bouchier IAD (1980). Cholecystitis: A fine structural analysis. J. Pathol. 130(1): 1-13.
14. Horä F. and Schulz H. (1970). Ultrastructure of the strawberry gallbladder. Beitr. Pathol. Anat. 141: 195-212.
15. Jacyna MR, Ross PE, Bakar MA, Hopwood D., and Bouchier IA (1987). Characteristics of cholesterol absorption by human gallbladder: Relevance to cholesterolosis. J. Clin. Pathol. 40: 524-529.
16. Johnson FR, McMinn RMH, and Birchenough RF (1962). The ultrastructure of the gallbladder epithelium of the dog. J. Anat. London 96(4): 477-487.
17. Kaminsky DL, Deshpand YG, Qualy J., and Thomas LA (1985). The role of prostaglandins in feline experimental cholecystitis. Surgery 98(4): 760-768.
18. Kaye JI, Wheeler HO, Whitlock RT, and Lane N. (1966). Fluid transport in the rabbit gallbladder. J. Cell Biol. 30: 237-268.
19. Koga A. (1985). Fine structure of the human gallbladder with cholesterosis with special reference to the mechanism of lipid accumulation. Br. J. Exp. Pathol. 66: 605-611.
20. Koga A., Todo S., and Nishimura M. (1975). Electron microscopic observations on the cholesterol distributed in the epithelial cells of the gallbladder. Histochemistry 44: 303-306.
21. Leyssac PP, Bukhave K., and Frederiksen O. (1974). Inhibitors effect of prostaglandins on isosmotic fluid transport by rabbit gall-bladder in vitro, and its modification by blockade of endogenous PGEbiosynthesis with indomethacin. Acta Physiol. Scand. 92: 496-507.
22. Luciano L. (1989). Morphological aspects of cholesterol storage in the human gallbladder. Prog. Clin. Biol. Res. 295: 269-275.
23. Neiderhiser DH, Harmon CK, and Roth HP (1976). Absorption of cholesterol by the gallbladder. J. Lipid Res. 17: 117-124.
24. Neiderhiser DH, Morningstar WA, and Roth HP (1973). Absorption of lecithin and lysolecithin by the gallbladder. J. Lab. Clin. Med. 82: 891-897.
25. Nevalainen T. and Laito M. (1972). Ultrastructure of gallbladder with cholesterolosis. Virchows Arch. Abst. B Zallpathol. 10: 237-242.
26. Ostrow JD (1967). Absorption of bile pigments by the gallbladder. J. Clin. Invest. 46: 2035-2052.
27. Ostrow JD (1971). Absorption of organic compounds by the injured gallbladder. J. Lab. Clin. Med. 78: 255-264.
28. Partin JC and Schubert WK (1969). Small intestinal mucosa in cholesterol ester storage disease. Gastroenterology 57(5): 542-558.
29. Subbia RMT and Dicke BA (1977). Presence of cholesterol ester synthetase activity in guinea pig gallbladder epithelium. Biochem. Biophys. Acta Comm. 74(3): 1273-1279.
30. Svanvik J., Pellegrini CA, Allen B., Bernhoft R., and Way LW (1986). Transport of fluid and biliary lipids in the canine gallbladder in experimental cholecystitis. J. Surg. Res. 41: 425-431.
31. Svanvik J., Thornell E., and Zellergren L. (1981). Gallbladder function in experimental cholecystitis. Surgery 89: 500-506.
32. Swell R., Trait EC, Hopper R., Field H., and Treadwell CR (1959). The mechanism of cholesterol absorption. Ann. N.Y. Acad. Sci. 72: 813-825.
33. Taoka H. (1991). Experimental study on the pathogenesis of acute acalculous cholecystitis, with special reference to the roles of microcirculatory disturbances, free radicals and membrane-bound phospholipase A2. Gastroenterol. Jap. 26(5): 634-644.
34. Tilvis RS, Aro J., Strandberg TE, Lempinen M., and Miettinen TA (1982). Lipid composition of bile and gallbladder mucosa in patients with acalculous cholesterolosis. Gastroenterology 82(4): 607-615.
35. Yamada E. (1955). The fine structure of the gallbladder epithelium of the mouse. J. Biochem. Biophys. Cytol. 1: 445-458.
36. Yamada K. (1962). Morphological and histochemical aspects of secretion in the gallbladder epithelium of the guinea pig. Anat. Rev. 144: 117-123.