메뉴 건너뛰기




Volumn 98, Issue 5, 1996, Pages 859-871

Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6- month randomized multicenter trial

Author keywords

5 lipoxygenase inhibitors; Adverse effects; antiinflammatory agents; asthma; bronchial diseases; corticosteroids; leukotrienes; pulmonary function tests; zileuton; agonists

Indexed keywords

LEUKOTRIENE; LIPOXYGENASE INHIBITOR; ZILEUTON;

EID: 0029853741     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)80002-9     Document Type: Article
Times cited : (230)

References (36)
  • 1
    • 0028566488 scopus 로고
    • The role of leukotrienes in inflammation
    • WR Henderson Jr The role of leukotrienes in inflammation Ann Int Med 121 1994 684 697
    • (1994) Ann Int Med , vol.121 , pp. 684-697
    • Henderson, WR1
  • 2
    • 0025201725 scopus 로고
    • Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis
    • GK Reid S Kargman PJ Vickers JA Mancini C Leveille D Ethier Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis J Biol Chem 265 1990 19818 19823
    • (1990) J Biol Chem , vol.265 , pp. 19818-19823
    • Reid, GK1    Kargman, S2    Vickers, PJ3    Mancini, JA4    Leveille, C5    Ethier, D6
  • 3
    • 0021135327 scopus 로고
    • Arachidonic acid metabolism among human mononuclear leukocytes: lipoxygenase-related pathways
    • ME Goldyne GH Burrish P Poubelle P Borgeat Arachidonic acid metabolism among human mononuclear leukocytes: lipoxygenase-related pathways J Biol Chem 259 1984 8815 8819
    • (1984) J Biol Chem , vol.259 , pp. 8815-8819
    • Goldyne, ME1    Burrish, GH2    Poubelle, P3    Borgeat, P4
  • 8
    • 0023554640 scopus 로고
    • Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects
    • JG Kirby FE Hargreave GJ Gleich PM. O’Byrne Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects Am Rev Respir Dis 136 1987 379 383
    • (1987) Am Rev Respir Dis , vol.136 , pp. 379-383
    • Kirby, JG1    Hargreave, FE2    Gleich, GJ3    O’Byrne, PM.4
  • 9
    • 0022353841 scopus 로고
    • Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction
    • KC Flint KBP Leung BN Hudspith J Brostoff FL Pearce NM Johnson Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction BMJ 291 1985 923 926
    • (1985) BMJ , vol.291 , pp. 923-926
    • Flint, KC1    Leung, KBP2    Hudspith, BN3    Brostoff, J4    Pearce, FL5    Johnson, NM6
  • 10
    • 0023831561 scopus 로고
    • Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma
    • AJ Wardlaw S Dunnette GJ Gleich JV Collins AB Kay Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma Am Rev Respir Dis 137 1988 62 69
    • (1988) Am Rev Respir Dis , vol.137 , pp. 62-69
    • Wardlaw, AJ1    Dunnette, S2    Gleich, GJ3    Collins, JV4    Kay, AB5
  • 12
    • 0026333085 scopus 로고
    • Activated T-cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
    • C Walker MK Kaegi P Braun K. Blaser Activated T-cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity J ALLERGY CLIN IMMUNOL 88 1991 935 942
    • (1991) J ALLERGY CLIN IMMUNOL , vol.88 , pp. 935-942
    • Walker, C1    Kaegi, MK2    Braun, P3    Blaser, K.4
  • 16
    • 0024473106 scopus 로고
    • Effects of leukotriene B4 in the human lung: recruitment of neutrophils into the alveolar spaces without a change in protein permeability
    • 4 in the human lung: recruitment of neutrophils into the alveolar spaces without a change in protein permeability J Clin Invest 84 1989 1609 1619
    • (1989) J Clin Invest , vol.84 , pp. 1609-1619
    • Martin, TR1    Pistorese, BP2    Chi, EY3    Goodman, RB4    Matthay, MA5
  • 18
    • 0000747598 scopus 로고
    • Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response
    • SE Dahlen J Bjork P Hedqvist KE Arfors S Hammarstrom JA Lindgren Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response Proc Natl Acad Sci USA 78 1981 3887 3891
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 3887-3891
    • Dahlen, SE1    Bjork, J2    Hedqvist, P3    Arfors, KE4    Hammarstrom, S5    Lindgren, JA6
  • 19
    • 0019254822 scopus 로고
    • Leukotrienes are potent constrictors of human bronchi
    • SE Dahlen P Hedqvist S Hammarstrom B Samuelsson Leukotrienes are potent constrictors of human bronchi Nature 228 1980 484 486
    • (1980) Nature , vol.228 , pp. 484-486
    • Dahlen, SE1    Hedqvist, P2    Hammarstrom, S3    Samuelsson, B4
  • 20
    • 0019966111 scopus 로고
    • Bronchoconstrictor effects of leukotriene C in humans
    • JN Weiss JM Drazen N Coles Bronchoconstrictor effects of leukotriene C in humans Science 216 1982 196 198
    • (1982) Science , vol.216 , pp. 196-198
    • Weiss, JN1    Drazen, JM2    Coles, N3
  • 21
    • 0021269295 scopus 로고
    • Comparative effects of inhaled leukotriene C4, leukotriene D4 and histamine in normal subjects
    • 4 and histamine in normal subjects Thorax 39 1984 500 504
    • (1984) Thorax , vol.39 , pp. 500-504
    • Barnes, NC1    Piper, PJ2    Costello, JF3
  • 22
    • 0025284206 scopus 로고
    • Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge
    • 4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge Am Rev Respir Dis 142 1990 112 119
    • (1990) Am Rev Respir Dis , vol.142 , pp. 112-119
    • Wenzel, SE1    Larsen, GL2    Johnson, K3    Voelkel, NF4    Westcott, JY5
  • 26
    • 0026332275 scopus 로고
    • Pharmacokinetics, safety and ability to diminish leukotriene synthesis by zileuton, an inhibitor of 5-lipoxygenase
    • P Rubin L Dubé R Braeckman L Swanson R Hansen D Albert Pharmacokinetics, safety and ability to diminish leukotriene synthesis by zileuton, an inhibitor of 5-lipoxygenase Agents Actions 35 1991 103 116
    • (1991) Agents Actions , vol.35 , pp. 103-116
    • Rubin, P1    Dubé, L2    Braeckman, R3    Swanson, L4    Hansen, R5    Albert, D6
  • 27
    • 0027369276 scopus 로고
    • The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma
    • E Israel P Rubin JP Kemp J Grossman W Pierson SC Siegel The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma Ann Intern Med 119 1993 1059 1066
    • (1993) Ann Intern Med , vol.119 , pp. 1059-1066
    • Israel, E1    Rubin, P2    Kemp, JP3    Grossman, J4    Pierson, W5    Siegel, SC6
  • 28
    • 0025685169 scopus 로고
    • Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor
    • HR Knapp Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor N Engl J Med 323 1990 1745 1748
    • (1990) N Engl J Med , vol.323 , pp. 1745-1748
    • Knapp, HR1
  • 29
    • 0003525252 scopus 로고
    • COSTART: coding symbols for thesaurus of adverse reaction terms
    • Division of Drug and Biological Product Experience COSTART: coding symbols for thesaurus of adverse reaction terms 3rd ed 1989 Department of Health and Human Services Rockville (MD)
    • (1989)
    • Division of Drug and Biological Product Experience1
  • 30
    • 0029915834 scopus 로고    scopus 로고
    • Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma: a randomized controlled trial
    • E Israel J Cohn L Dube JM Drazen the Zileuton Clinical Trial Group Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma: a randomized controlled trial JAMA 275 1996 931 936
    • (1996) JAMA , vol.275 , pp. 931-936
    • Israel, E1    Cohn, J2    Dube, L3    Drazen, JM4    the Zileuton Clinical Trial Group5
  • 31
    • 0016864288 scopus 로고
    • Total eosinophil counts in the management of bronchial asthma
    • HR Horn ED Robin J Theodore A VanKessel Total eosinophil counts in the management of bronchial asthma N Engl J Med 292 1975 1152 1155
    • (1975) N Engl J Med , vol.292 , pp. 1152-1155
    • Horn, HR1    Robin, ED2    Theodore, J3    VanKessel, A4
  • 32
    • 0023212275 scopus 로고
    • Peripheral blood eosinophil counts and bronchial responsiveness
    • KJ Taylor AR Luksza Peripheral blood eosinophil counts and bronchial responsiveness Thorax 42 1987 452 456
    • (1987) Thorax , vol.42 , pp. 452-456
    • Taylor, KJ1    Luksza, AR2
  • 33
    • 0027466759 scopus 로고
    • CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5: effect of glucocorticoid therapy
    • 4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5: effect of glucocorticoid therapy Am Rev Respir Dis 147 1993 540 547
    • (1993) Am Rev Respir Dis , vol.147 , pp. 540-547
    • Corrigan, CJ1    Haczku, A2    Gemou-Engesaeth, V3    Doi, S4    Kikuchi, Y5    Takatsu, K6
  • 34
    • 0028289793 scopus 로고
    • Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs
    • DC Underwood CJ Kotzer S Bochnowicz RR Osborn MA Luttmann DWP Hay Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs J Pharmacol Exp Ther 270 1994 250 259
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 250-259
    • Underwood, DC1    Kotzer, CJ2    Bochnowicz, S3    Osborn, RR4    Luttmann, MA5    Hay, DWP6
  • 36
    • 0023026165 scopus 로고
    • Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF-stimulated human myeloid colony formation
    • 4 as essential intermediates in CSF-stimulated human myeloid colony formation Exp Hematol 14 1986 760 765
    • (1986) Exp Hematol , vol.14 , pp. 760-765
    • Miller, AM1    Weiner, RS2    Ziboh, VA3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.