Effect of a novel 5-lipoxygenase activating protein inhibitor, BAYx 1005, on asthma induced by cold dry air

Thorax

Volumn 52, Issue 12, 1997, Pages 1074-1077

  Fischer, Andrew R ^a   Rosenberg, Mitchell A ^a   Roth, Miriam ^a   Loper, Marlene ^b   Jungerwirth, Steven ^b   Israel, Elliot ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BAYER CORPORATION   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Asthma; Isocapnic hyperventilation; Leukotrienes

Indexed keywords

2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; PLACEBO;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; COLD; COLD AIR; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FORCED EXPIRATORY VOLUME; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030665470     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.12.1074     Document Type: Article

References (9)

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8. Diamant Z, Timmers MC, van der Veen H, Friedman BS, DeSmet M, Depre M, et al. The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo. J Allergy Clin Immunol 1995;95: 42-51.
9. Hatzelmann A, Fruchtmann R, Mohrs KH, Raddatz S, Muller-Peddinghaus R. Mode of action of the new selective leukotriene synthesis inhibitor BAYx 1005 [(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid] and structurally related compounds. Biochem Pharmacol 1995; 45:101-11.