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Volumn 25, Issue 4, 1997, Pages 209-216

Biosynthesis inhibitors for leukotrienes in bronchial asthma

Author keywords

5 Lipoxygenase Protein Inhibitors; 5 Lipoxygenase Activating Protein Inhibitors; A 64077; A 78773; AA 681; ABT 761; BAYX 1005; BI 6239; FR 110302; L 699333; L 746530; MK 0591; MK 886; U 60257; ZD 2138; ZM 230487

Indexed keywords

2 (4 (QUINOLIN 2 YL METHOXY)PHENYL) 2 CYCLOPENTYLACETIC ACID; 2,2 DIBUTYL 1,2,3,4 TETRAHYDRO 5 (2 QUINOLYLMETHOXY) 1 NAPHTHOL; 2-(4-(QUINOLIN-2-YL-METHOXY)PHENYL)-2-CYCLOPENTYLACETIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; ANTIASTHMATIC AGENT; BENZOQUINONE DERIVATIVE; DOCEBENONE; DRUG DERIVATIVE; HYDROXYUREA; INDOLE DERIVATIVE; LEUKOTRIENE; LIPOXYGENASE INHIBITOR; NAPHTHOL DERIVATIVE; PIRIPROST; PROSTACYCLIN; PYRAN DERIVATIVE; QUINOLINE DERIVATIVE; QUINOLONE DERIVATIVE; ZILEUTON;

EID: 0031179948     PISSN: 03010546     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (48)
  • 1
    • 84944495485 scopus 로고
    • Liberation of histamine and formation of lysolethicin like substances by cobra venom
    • Feldberg W, Kellaway CH. Liberation of histamine and formation of lysolethicin like substances by cobra venom. J Physiol 1938;94:187-226
    • (1938) J Physiol , vol.94 , pp. 187-226
    • Feldberg, W.1    Kellaway, C.H.2
  • 2
    • 84980124399 scopus 로고
    • The liberation of a slow reacting smooth muscle stimulating substance of anaphylaxis
    • Kellaway CH, Threthewie RE. The liberation of a slow reacting smooth muscle stimulating substance of anaphylaxis J Exp Physiol 1940,30.121-45
    • (1940) J Exp Physiol , vol.30 , pp. 121-145
    • Kellaway, C.H.1    Threthewie, R.E.2
  • 3
    • 0020597565 scopus 로고
    • Leukotrienes mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson B Leukotrienes mediators of immediate hypersensitivity reactions and inflammation Science 1983;220 (4597):568-75
    • (1983) Science , vol.220 , Issue.4597 , pp. 568-575
    • Samuelsson, B.1
  • 4
    • 0018418754 scopus 로고
    • Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes Formation of a novel dihydroxy eicosanoic acid
    • Borgeat P, Samuelsson B. Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes Formation of a novel dihydroxy eicosanoic acid J Biol Chem 1979,254:2643-6.
    • (1979) J Biol Chem , vol.254 , pp. 2643-2646
    • Borgeat, P.1    Samuelsson, B.2
  • 5
    • 0001465756 scopus 로고
    • Leukotriene C: A slow reacting substance from murine mastocytoma cells
    • Murphy RC, Hammarstrom S, Samuelsson B. Leukotriene C: a slow reacting substance from murine mastocytoma cells. Proc Natl Acad Sci USA 1979;76.4275-9
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4275-4279
    • Murphy, R.C.1    Hammarstrom, S.2    Samuelsson, B.3
  • 6
    • 0026059488 scopus 로고
    • Arachidonic acid metabolism
    • Holtzman MJ. Arachidonic acid metabolism. Am Rev Respir Dis 1991,143:1 188-203.
    • (1991) Am Rev Respir Dis , vol.143 , Issue.1 , pp. 188-203
    • Holtzman, M.J.1
  • 7
    • 0023589276 scopus 로고
    • Leukotrienes and airway responses
    • Drazen JM, Austen KF. Leukotrienes and airway responses Am Rev Respir Dis 1987;136:4:985-98
    • (1987) Am Rev Respir Dis , vol.136 , Issue.4 , pp. 985-998
    • Drazen, J.M.1    Austen, K.F.2
  • 10
    • 0025905604 scopus 로고
    • Eicosanoids and platelet-activating factor in allergic respiratory diseases
    • Henderson WR Jr. Eicosanoids and platelet-activating factor in allergic respiratory diseases Am Rev Respir Dis 1991;143 5 Pt 2:S86-90
    • (1991) Am Rev Respir Dis , vol.143 , Issue.5 PART 2
    • Henderson Jr., W.R.1
  • 12
    • 0023177955 scopus 로고
    • Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
    • Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987;237:4819:1171-6
    • (1987) Science , vol.237 , Issue.4819 , pp. 1171-1176
    • Samuelsson, B.1    Dahlen, S.E.2    Lindgren, J.A.3    Rouzer, C.A.4    Serhan, C.N.5
  • 14
    • 0025022489 scopus 로고
    • Requirement of a 5-lipoxygenase-activating protein for leukotriene
    • Dixon RA, Diehl RE, Opas E, Rands E, Vickers PJ, Evans JF et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene. Nature 1990;343:6255 282-4
    • (1990) Nature , vol.343 , Issue.6255 , pp. 282-284
    • Dixon, R.A.1    Diehl, R.E.2    Opas, E.3    Rands, E.4    Vickers, P.J.5    Evans, J.F.6
  • 15
    • 0025021789 scopus 로고
    • Identification and isolation of a membrane protein necessary for leukotriene production
    • Miller DK, Gillard JW, Vickers PJ, Sadowski S, Leveille C, Mancini JA et al. Identification and isolation of a membrane protein necessary for leukotriene production. Nature 1990;343. 6255.278-81.
    • (1990) Nature , vol.343 , Issue.6255 , pp. 278-281
    • Miller, D.K.1    Gillard, J.W.2    Vickers, P.J.3    Sadowski, S.4    Leveille, C.5    Mancini, J.A.6
  • 16
    • 2442497960 scopus 로고    scopus 로고
    • Leukotrienes: They receptors, antagonists and synthesis inhibitors
    • Townley RG, Agrawal DK, eds. New York: Marcel Dekker
    • Crocker IC, Townley RG. Leukotrienes: they receptors, antagonists and synthesis inhibitors In: Townley RG, Agrawal DK, eds. Immunopharmacology of allergic disease. New York: Marcel Dekker, 1996 p.433-61.
    • (1996) Immunopharmacology of Allergic Disease , pp. 433-461
    • Crocker, I.C.1    Townley, R.G.2
  • 17
    • 0028090628 scopus 로고
    • Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma
    • Jonsson EWE, Dahlen SE Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma. J Pharmacol Exp Ther 1994,271:2:615-23.
    • (1994) J Pharmacol Exp Ther , vol.271 , Issue.2 , pp. 615-623
    • Jonsson, E.W.E.1    Dahlen, S.E.2
  • 18
    • 0027447228 scopus 로고
    • Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: Pharmacological evidence obtained with tissues from asthmatic and nonasthmatic subjects
    • Bjorck T, Dahlen SE Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and nonasthmatic subjects Pulm Pharinacol 1993;6:1:87-96.
    • (1993) Pulm Pharinacol , vol.6 , Issue.1 , pp. 87-96
    • Bjorck, T.1    Dahlen, S.E.2
  • 19
    • 0028821025 scopus 로고
    • The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo
    • Diamant Z, Timmers MC, van der Veen H, Friedman BS, De Smet M, Depre M et al. The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo. J Allergy Clin Immunol 1995,95:1Pt 1: 42-51.
    • (1995) J Allergy Clin Immunol , vol.95 , Issue.1 PART 1 , pp. 42-51
    • Diamant, Z.1    Timmers, M.C.2    Van Der Veen, H.3    Friedman, B.S.4    De Smet, M.5    Depre, M.6
  • 21
    • 0027238552 scopus 로고
    • Leukotriene antagonists and inhibitors as modulators of IgE-mediated reactions
    • Ford Hutchison AW. Leukotriene antagonists and inhibitors as modulators of IgE-mediated reactions. Springle Semin Immunopathol 1993;15:37-50.
    • (1993) Springle Semin Immunopathol , vol.15 , pp. 37-50
    • Ford Hutchison, A.W.1
  • 22
    • 0027406030 scopus 로고
    • Role of leukotrienes in airway hyperresponsiveness in guinea pigs
    • Ishida K, Thomson RJ, Schellenberg RR Role of leukotrienes in airway hyperresponsiveness in guinea pigs. Br J Phannacol 1993;108:3:700-4
    • (1993) Br J Phannacol , vol.108 , Issue.3 , pp. 700-704
    • Ishida, K.1    Thomson, R.J.2    Schellenberg, R.R.3
  • 25
    • 0025312294 scopus 로고
    • Randomized double-blind, placebo-controlled clinical trial of a selective 5-lipoxygenase inhibitor (AA-861) for the prevention of seasonal allergic rhinitis
    • Ancill RJ, Takahashi Y, Kibune Y, Campbell R, Smith JR. Randomized double-blind, placebo-controlled clinical trial of a selective 5-lipoxygenase inhibitor (AA-861) for the prevention of seasonal allergic rhinitis J Int Med Res 1990;18:75-88.
    • (1990) J Int Med Res , vol.18 , pp. 75-88
    • Ancill, R.J.1    Takahashi, Y.2    Kibune, Y.3    Campbell, R.4    Smith, J.R.5
  • 27
    • 0025685169 scopus 로고
    • Reduced allergen-induced nasal symptoms and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor
    • Knapp HR Reduced allergen-induced nasal symptoms and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor [See comments]. N Engl J Med 1990;323.1745-8.
    • (1990) N Engl J Med , vol.323 , pp. 1745-1748
    • Knapp, H.R.1
  • 29
    • 0027762572 scopus 로고
    • The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin
    • Israel E, Fischer AR, Rosenberg MA, Lilly CM, Gallery JC, Shapiro J et al. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin Am Rev Respir Dis 1993;148:6Pt 1.1447-51.
    • (1993) Am Rev Respir Dis , vol.148 , Issue.6 PART 1 , pp. 1447-1451
    • Israel, E.1    Fischer, A.R.2    Rosenberg, M.A.3    Lilly, C.M.4    Gallery, J.C.5    Shapiro, J.6
  • 30
    • 0026078163 scopus 로고
    • Effects of a 5-lypoxigenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients
    • Hui KP, Taylor IK, Taylor GW, Rubin P, Kesterton J, Barnes NC et al Effects of a 5-lypoxigenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax 1991,46.184-9.
    • (1991) Thorax , vol.46 , pp. 184-189
    • Hui, K.P.1    Taylor, I.K.2    Taylor, G.W.3    Rubin, P.4    Kesterton, J.5    Barnes, N.C.6
  • 31
    • 0026542531 scopus 로고
    • Phase II study of the safety and efficacy of a 5-lipoxygenase inhibitor in patients with ulcerative colitis
    • Collawn C, Rubin P, Perez N, Bobadilla J, Cabrera G. Reyes E Phase II study of the safety and efficacy of a 5-lipoxygenase inhibitor in patients with ulcerative colitis Am J Gastroenterol 1992;87:342-6.
    • (1992) Am J Gastroenterol , vol.87 , pp. 342-346
    • Collawn, C.1    Rubin, P.2    Perez, N.3    Bobadilla, J.4    Cabrera, G.5    Reyes, E.6
  • 33
    • 0029049530 scopus 로고
    • Treatment of chronic stable asthma with drugs active on the 5-lipoxygenase patway
    • Drazen JM, Israel E. Treatment of chronic stable asthma with drugs active on the 5-lipoxygenase patway Int Arch Allergy Immunol 1995;107:3.319-20
    • (1995) Int Arch Allergy Immunol , vol.107 , Issue.3 , pp. 319-320
    • Drazen, J.M.1    Israel, E.2
  • 34
    • 0029937854 scopus 로고    scopus 로고
    • Inhibition of exercice-induced bronchospasm by zileuton: A 5-lipoxygenase inhibitor
    • Meltzer SS, Hasday JD, Cohn J, Bleecker ER. Inhibition of exercice-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor Am J Respir Crit Care Med 1996;153 931-5
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 931-935
    • Meltzer, S.S.1    Hasday, J.D.2    Cohn, J.3    Bleecker, E.R.4
  • 35
    • 2542487176 scopus 로고    scopus 로고
    • Zileuton, a new 5-lipoxygenase pathway inhibitor
    • Swanson U, Doan TT, Dube LM. Zileuton, a new 5-lipoxygenase pathway inhibitor. ACI International 1996,8:134.
    • (1996) ACI International , vol.8 , pp. 134
    • Swanson, U.1    Doan, T.T.2    Dube, L.M.3
  • 38
    • 0026438757 scopus 로고
    • Preclinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase
    • McMillan RM, Spruce KE, Crawley GC, Walker ER, Foster SJ. Preclinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br J Pharmacol 1992; 107.1042-7.
    • (1992) Br J Pharmacol , vol.107 , pp. 1042-1047
    • McMillan, R.M.1    Spruce, K.E.2    Crawley, G.C.3    Walker, E.R.4    Foster, S.J.5
  • 39
    • 0026662844 scopus 로고
    • A 5-lipoxygenase inhibitor FR-110302, suppresses hyperresponsiveness and lung eosinophilia induced by Sepharex particles in rats
    • Asano M, Inamura N, Nakahara K, Nagayoshi T, Isono T, Hamada K et al A 5-lipoxygenase inhibitor FR-110302, suppresses hyperresponsiveness and lung eosinophilia induced by Sepharex particles in rats. Agents Actions 1992;36:215-21.
    • (1992) Agents Actions , vol.36 , pp. 215-221
    • Asano, M.1    Inamura, N.2    Nakahara, K.3    Nagayoshi, T.4    Isono, T.5    Hamada, K.6
  • 40
    • 0027477589 scopus 로고
    • The role of 5-lipoxygenase products in preclinical models of asthma
    • Wegner CD, Gundel RH, Abraham WM The role of 5-lipoxygenase products in preclinical models of asthma. J Allergy Clin Immunol 1993;91:917-29
    • (1993) J Allergy Clin Immunol , vol.91 , pp. 917-929
    • Wegner, C.D.1    Gundel, R.H.2    Abraham, W.M.3
  • 41
    • 2542443293 scopus 로고
    • The influence of the 5-lipoxygenase inhibitor A-78773 on the nasal response to allergen in rhinitis
    • Howart PH, Harrison K, Lau L, Dube L, Cohn J. The influence of the 5-lipoxygenase inhibitor A-78773 on the nasal response to allergen in rhinitis J Allergy Clin Immunol 1994,93:297
    • (1994) J Allergy Clin Immunol , vol.93 , pp. 297
    • Howart, P.H.1    Harrison, K.2    Lau, L.3    Dube, L.4    Cohn, J.5
  • 42
    • 0028892993 scopus 로고
    • Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors
    • Bell RL, Bouska JB, Malo PE, Lanni C, Harris RR, Otis ER et al. Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors J Pharmacol Exp Ther 1995;272:724-31
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 724-731
    • Bell, R.L.1    Bouska, J.B.2    Malo, P.E.3    Lanni, C.4    Harris, R.R.5    Otis, E.R.6
  • 44
  • 45
    • 0028884755 scopus 로고
    • (R)-(+)-N-3-[5-[(4-fluorophenyl) methyl] -2-thienyl]-1-methyl-2-propynyl-hydroxyurea(ABT-761), a second generation 5-lipoxygenase inhibitor
    • Brooks CD, Stewart AO, Basha A, Bhatia P, Ratajczyk JD, Martin JG et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl) methyl] -2-thienyl]-1-methyl-2-propynyl-hydroxyurea(ABT-761), a second generation 5-lipoxygenase inhibitor. J Med Chem 1995;38: 4768-75
    • (1995) J Med Chem , vol.38 , pp. 4768-4775
    • Brooks, C.D.1    Stewart, A.O.2    Basha, A.3    Bhatia, P.4    Ratajczyk, J.D.5    Martin, J.G.6
  • 46
    • 0029589314 scopus 로고
    • Microsomal metabolism of the 5-lipoxygenase inhibitors L-746530 and L-739010 to reactive immediates that covalenty bind to protein: The role of the 6,8-dioxabicyclo [3.2.1] octanyl moiety
    • Chauret N, Nicoll-Griffith D, Friesen R, Li C, Trimble L, Dube D et al. Microsomal metabolism of the 5-lipoxygenase inhibitors L-746530 and L-739010 to reactive immediates that covalenty bind to protein: the role of the 6,8-dioxabicyclo [3.2.1] octanyl moiety. Drugs Metab Dispos 1995;23:12:1325-34.
    • (1995) Drugs Metab Dispos , vol.23 , Issue.12 , pp. 1325-1334
    • Chauret, N.1    Nicoll-Griffith, D.2    Friesen, R.3    Li, C.4    Trimble, L.5    Dube, D.6
  • 47
    • 0028258361 scopus 로고
    • Thiopyrano [2,3,4-cd] indoles as 5-lipoxygenase inhibitors: Syntesis, biological profile, and resolution of 2-[2-[1-(4-chorobenzyl)-4-methyl-6-[5-phenylpyridin-2yl]A5-dihidro-1 H-thiopyrano [2,3,4-cd] indol-2-yl] ethoxy] butanoic acid
    • Hutchison JH, Riendeau D, Brideau C, Chan C, Falgueyret JP, Guay J et al. Thiopyrano [2,3,4-cd] indoles as 5-lipoxygenase inhibitors: syntesis, biological profile, and resolution of 2-[2-[1-(4-chorobenzyl)-4-methyl-6-[(5-phenylpyridin-2yl]A5-dihidro-1 H-thiopyrano [2,3,4-cd] indol-2-yl] ethoxy] butanoic acid. J Med Chem 1994;37:8:1153-64
    • (1994) J Med Chem , vol.37 , Issue.8 , pp. 1153-1164
    • Hutchison, J.H.1    Riendeau, D.2    Brideau, C.3    Chan, C.4    Falgueyret, J.P.5    Guay, J.6
  • 48
    • 0028333049 scopus 로고
    • The 5-lipoxygenase inhibitors ZD-2138 and ZM-230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses
    • Kusner EJ, Bucker CK, Dea DM, DeHaas CJ, Marks RL, Krell RD. The 5-lipoxygenase inhibitors ZD-2138 and ZM-230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses. Eur Pharmacol 1994;257: 3.285-92.
    • (1994) Eur Pharmacol , vol.257 , Issue.3 , pp. 285-292
    • Kusner, E.J.1    Bucker, C.K.2    Dea, D.M.3    DeHaas, C.J.4    Marks, R.L.5    Krell, R.D.6


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