Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 355, Issue 4, 1997, Pages 470-474

  Raychaudhuri, Anil ^a   Chertock, Herbert ^a   Chovan, James ^a   Jones, Lisa S ^a   Kimble, Earl F ^a   Kowalski, Timothy J ^a   Peppard, Jane ^a   White, D Hope ^a   Satoh, Yoshitaka ^a   Roland, Dennis ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Calcium ionophore (A23187); Carrageenan pleurisy; CGS 23885 (HPLC); LTB4; LTC4 4 E4; PGE2; Rat; TXB2

Indexed keywords

CARRAGEENAN; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; LIPOXYGENASE INHIBITOR; 3 [[N (AMINOCARBONYL) N HYDROXYAMINO]METHYL] 6 PHENOXYCHROMENE; CHROMONE DERIVATIVE; HYDROXYLAMINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOASSAY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLEURA CAVITY; PLEURA FLUID; PLEURISY; RAT; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; SPRAGUE DAWLEY RAT;

ANIMALS; CHROMONES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYLAMINES; LEUKOTRIENE B4; LIPOXYGENASE INHIBITORS; MALE; PLEURISY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030612679     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00004971     Document Type: Article

References (26)

1. Bosman B (1994) Testing of lipoxygenase inhibitors, cyclooxygenase inhibitors, drugs with immunomodulating properties and some reference antipsoriatic drugs in the modified mouse tail test, an animal model of psoriasis. Skin Pharmacol 7:324-334
2. 4. An inflammatory mediator in vivo. Prostaglandins 22:213-222
3. 4 receptors on rat and human leukocyte membranes. Prostaglandins 32:503-516
4. 4 antagonists. Curr Opin Invest Drugs 3:13-22
5. 4 in inflammation. Crit Rev Immunol 10:1-12
6. Ford-Hutchinson AW (1993) 5-Lipoxygenase activation in psoriasis. A dead issue? Skin Pharmacol 6:292-297
7. Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJH (1980) Leukotriene B, a potent chemokinetic and aggregating substance, released from polymorphonuclear leukocytes. Nature 286:264-265
8. Ford-Hutchinson AW (1985) Leukotrienes: Thier formation and role as inflammatory mediators. Fed Proc 44:25-29
9. Ford-Hutchinson AW (1991) FLAP: a novel drug target for inhibiting the synthesis of leukotrienes. Trends Pharmaeol Sci 12:68-70
10. 4. Biochem Pharmacol 35:1709-1717
11. Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Foster A, Fortin R, Leger S, McFarlane CS, Morton H, Piechuta H, Riendeau D, Rouzer CA, Rokach J, Young R, MacIntyre E, Peterson H, Eirmann G, Hopple S, Hupe L, Meurer R, Opas E, Pacholok S (1989) L-633,536 (MK886), a novel orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 67:456-464
12. Goetzl EJ, Pickett WC (1980) The human PMN leukocyte chemotactic activity of complex of hydroxyeicosatetraenoic acids (HETES). J Immunol 125:1789-1791
13. Hagiwara M, Mikami T, Iwamura S, Miyazawa K, Kobayashi M, Miyasaka K (1991) Effects of TZI-41127, a novel selective 5-lipoxygenas inhibitor, on A23187-induced pleurisy in rats. Eur J Pharmacol 199:69-75
14. Ku EC, Raychaudhuri A, Ghai G, Kimble EF, Lee WH, Colombo C, Dotson D, Oglesby TD (1988) Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. Biochim Biophys Acta 959:332-342
15. Palmer RMJ, Stepney RJ, Higgs GA, Eakins KE (1980) Chemokinetic activity of arachidonic acid lipoxygenase products on leucocytes of different species. Prostaglandins 20:411-418
16. Rane A, Oelz O, Frolich JC, Seyberth HW, Sweetman BJ, Watson JT, Wilkinson GR, Oates JA (1978) Relation between plasma concentration of indomethacin and its effect on prostaglandin synthesis and platelet aggregation in man. Clin Pharmacol Ther 23:658-668
17. 4 biosynthesis following calcium ionophore stimulation in the rat pleural cavity. Agents Actions Suppl 39:C43-C45
18. Raychaudhuri A, Colombo C, Pastor G, Wong M, Jeng AY (1991) Effect of capsaicin on carrageenan-induced inflammation in rat pleurisy and exudate substance P level. Agents Actions 34:251-253
19. 4 biosynthesis by disulfiram and A-64077 during carrageenan-induced pleurisy in the rat. Gen Pharmacol 22:371-374
20. Samuelsson B (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220:568-575
21. th ACS National Meeting, Denver, Colorado, MED1 143, March 28-April 2
22. Satoh Y, Stanton JL, Hutchinson AJ, Libby AH, Kowalski TJ, Lee WH, White DH, Kimble EF (1993b) Substituted chromones as potent, orally active 5-lipoxygenase inhibitors. J Med Chem 36:3580-3594
23. 4 in the skin of different laboratory animals in vivo. J Invest Dermatol 90:254
24. Wang J-P, Ho TF, Lin C-N, Teng CM (1994) Effect of norathyriol, isolated from Tripterospermum lunceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn-Schmiedehere's Arch Pharmacol 350:90-95
25. Wedmore CV, Williams TJ (1981) Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature 289:646-650
26. 2, and the vascular changes of inflammation. Br J Pharmacol 65:517-524