메뉴 건너뛰기




Volumn 52, Issue 4, 1997, Pages 348-354

Attenuation of early and late phase allergen-induced bronchoconstriction in asthmatic subjects by a 5-lipoxygenase activating protein antagonist, BAYx 1005

Author keywords

Allergens; Asthma; BAYx 1005; Leukotriene synthesis inhibition

Indexed keywords

2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; ALLERGEN; ARACHIDONATE 5 LIPOXYGENASE; PLACEBO;

EID: 0030996540     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.4.348     Document Type: Article
Times cited : (74)

References (36)
  • 3
    • 0019949885 scopus 로고
    • Allergen-induced increase in bronchial responsiveness to histamine: Relationship to the late asthmatic response and change in airway caliber
    • Cartier A, Thomson NC, Frith PA, Roberts R, Hargreave FE. Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol 1982; 70:170-7.
    • (1982) J Allergy Clin Immunol , vol.70 , pp. 170-177
    • Cartier, A.1    Thomson, N.C.2    Frith, P.A.3    Roberts, R.4    Hargreave, F.E.5
  • 6
    • 0019419918 scopus 로고
    • Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro
    • Hanna CJ, Bach MK, Pare PD, Schellenberg RR. Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro. Nature 1981;343-4.
    • (1981) Nature , pp. 343-344
    • Hanna, C.J.1    Bach, M.K.2    Pare, P.D.3    Schellenberg, R.R.4
  • 7
    • 0021269295 scopus 로고
    • Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects
    • Barnes NC, Piper PJ, Costello JF. Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. Thorax 1984;39:500-4.
    • (1984) Thorax , vol.39 , pp. 500-504
    • Barnes, N.C.1    Piper, P.J.2    Costello, J.F.3
  • 8
    • 0022459317 scopus 로고
    • Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls
    • Adelroth E, Morris MM, Hargreave FE, O'Byrne PM. Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. N Engl J Med 1986;315:480-4.
    • (1986) N Engl J Med , vol.315 , pp. 480-484
    • Adelroth, E.1    Morris, M.M.2    Hargreave, F.E.3    O'Byrne, P.M.4
  • 10
    • 0023589276 scopus 로고
    • State of the art: Leukotrienes and airway responses
    • Drazen JM, Austen KF. State of the art: leukotrienes and airway responses. Am Rev Respir Dis 1987;136:985-98.
    • (1987) Am Rev Respir Dis , vol.136 , pp. 985-998
    • Drazen, J.M.1    Austen, K.F.2
  • 14
    • 0020503729 scopus 로고
    • Investigation of leukotriene involvement in the vasopermeability response associated with guinea-pig tracheal anaphylaxis: Comparison with cutaneous anaphylaxis
    • Woodward DF, Wasserman MA, Weichmann BM. Investigation of leukotriene involvement in the vasopermeability response associated with guinea-pig tracheal anaphylaxis: comparison with cutaneous anaphylaxis. Eur J Pharmacol 1983;93:9-19.
    • (1983) Eur J Pharmacol , vol.93 , pp. 9-19
    • Woodward, D.F.1    Wasserman, M.A.2    Weichmann, B.M.3
  • 15
    • 0019971503 scopus 로고
    • Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro
    • Marom Z, Shelhamer JH, Bach MK, Morton DR, Kaliner M. Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro. Am Rev Respir Dis 1982;126:449-51.
    • (1982) Am Rev Respir Dis , vol.126 , pp. 449-451
    • Marom, Z.1    Shelhamer, J.H.2    Bach, M.K.3    Morton, D.R.4    Kaliner, M.5
  • 16
    • 0026066945 scopus 로고
    • Effect of cysteinyl-leukotriene receptor antagonist ICI 204 219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects
    • Taylor IK, O'Shaugnessy KM, Fuller RW, Dollery CT. Effect of cysteinyl-leukotriene receptor antagonist ICI 204 219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 1991;337:690-4.
    • (1991) Lancet , vol.337 , pp. 690-694
    • Taylor, I.K.1    O'Shaugnessy, K.M.2    Fuller, R.W.3    Dollery, C.T.4
  • 19
    • 0028821025 scopus 로고
    • The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo
    • Diamant Z, Timmers MC, van der Veen H, Friedman BS, de Smet M, Depre M, et al. The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo. J Allergy Clin Immunol 1995;95:42-51.
    • (1995) J Allergy Clin Immunol , vol.95 , pp. 42-51
    • Diamant, Z.1    Timmers, M.C.2    Van Der Veen, H.3    Friedman, B.S.4    De Smet, M.5    Depre, M.6
  • 20
    • 0027492042 scopus 로고
    • Mode of action of the new selective leukotriene synthesis inhibitor BAYx 1005 [(R)-2-[4-(Quinolin-2-yl methoxy)phenyl]-2-cyclopentyl] acetic acid and structurally related compounds
    • Hatzelmann A, Fruchtmann R, Mohrs KH, Raddatz S, Muler-Peddinghaus R. Mode of action of the new selective leukotriene synthesis inhibitor BAYx 1005 [(R)-2-[4-(Quinolin-2-yl methoxy)phenyl]-2-cyclopentyl] acetic acid] and structurally related compounds. Biochem Pharmacol 1993;45:101-11.
    • (1993) Biochem Pharmacol , vol.45 , pp. 101-111
    • Hatzelmann, A.1    Fruchtmann, R.2    Mohrs, K.H.3    Raddatz, S.4    Muler-Peddinghaus, R.5
  • 21
    • 0014979992 scopus 로고
    • Spirometric standards for healthy nonsmoking adults
    • Morris JF, Koski A, Johnson LC. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis 1971;103: 57-67.
    • (1971) Am Rev Respir Dis , vol.103 , pp. 57-67
    • Morris, J.F.1    Koski, A.2    Johnson, L.C.3
  • 22
    • 0023129148 scopus 로고
    • Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine
    • Cockcroft DW, Murdock KY, Kirby J, Hargreave FE. Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Am Rev Respir Dis 1987;135:264-7.
    • (1987) Am Rev Respir Dis , vol.135 , pp. 264-267
    • Cockcroft, D.W.1    Murdock, K.Y.2    Kirby, J.3    Hargreave, F.E.4
  • 24
    • 0018398041 scopus 로고
    • The two-period cross-over clinical trial
    • Hills M, Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol 1979;8:7-20.
    • (1979) Br J Clin Pharmacol , vol.8 , pp. 7-20
    • Hills, M.1    Armitage, P.2
  • 27
    • 0023745152 scopus 로고
    • 4 on the airway responsiveness to histamine in subjects with asthma and normal subjects
    • 4 on the airway responsiveness to histamine in subjects with asthma and normal subjects. J Allergy Clin Immunol 1988;82:654-60.
    • (1988) J Allergy Clin Immunol , vol.82 , pp. 654-660
    • Arm, J.P.1    Spur, B.W.2    Lee, T.H.3
  • 28
    • 0020642778 scopus 로고
    • 4: Comparison of potency in canine trachea in vivo
    • 4: comparison of potency in canine trachea in vivo. Prostaglandins 1983,25:237-43.
    • (1983) Prostaglandins , vol.25 , pp. 237-243
    • Johnson, H.G.1    McNee, M.L.2
  • 29
    • 0028566488 scopus 로고
    • The role of leukotrienes in inflammation
    • Henderson WR. The role of leukotrienes in inflammation. Ann Intern Med 1994;121:68-97.
    • (1994) Ann Intern Med , vol.121 , pp. 68-97
    • Henderson, W.R.1
  • 30
    • 0026078163 scopus 로고
    • Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients
    • Hui KP, Taylor IK, Taylor GW, Rubin P, Kesterson J, Barnes NC, et al. Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax 1991;46:184-9.
    • (1991) Thorax , vol.46 , pp. 184-189
    • Kp, H.1    Taylor, I.K.2    Taylor, G.W.3    Rubin, P.4    Kesterson, J.5    Barnes, N.C.6
  • 31
    • 0027938710 scopus 로고
    • Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses
    • Nasser SM, Bell GS, Hawksworth RJ, Spruce KE, MacMillan R, Williams AJ, et al. Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses. Thorax 1994;49:743-8.
    • (1994) Thorax , vol.49 , pp. 743-748
    • Nasser, S.M.1    Bell, G.S.2    Hawksworth, R.J.3    Spruce, K.E.4    MacMillan, R.5    Williams, A.J.6
  • 33
    • 0028280329 scopus 로고
    • (R)2-[4-(Quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid (BAYx 1005), a potent leukotriene synthesis inhibitor: Effects on anti-IgE challenge in human airways
    • Gorenne I, Labat C, Gascard JP, Norel X, Muller-Peddinghaus R, Mohrs KH, et al. (R)2-[4-(Quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAYx 1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways. J Pharmacol Exp Ther 1994;268:868-72.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 868-872
    • Gorenne, I.1    Labat, C.2    Gascard, J.P.3    Norel, X.4    Muller-Peddinghaus, R.5    Mohrs, K.H.6
  • 35
    • 0030925781 scopus 로고    scopus 로고
    • Inhibition of allergen-induced airway obstruction and leukotriene generation in atopic asthmatic subjects by the leukotriene biosynthesis inhibitor BAYx 1005
    • Dahlén B, Kumlin M, Ihre E, Zetterstrom O, Dahlén S-E. Inhibition of allergen-induced airway obstruction and leukotriene generation in atopic asthmatic subjects by the leukotriene biosynthesis inhibitor BAYx 1005. Thorax 1997;52:342-7.
    • (1997) Thorax , vol.52 , pp. 342-347
    • Dahlén, B.1    Kumlin, M.2    Ihre, E.3    Zetterstrom, O.4    Dahlén, S.-E.5
  • 36
    • 85036446799 scopus 로고    scopus 로고
    • Reproducibility and utility of methacholme airway responsivenes in studies of allergen-induced asthma
    • Inman MD, Watson R, O'Byrne PM. Reproducibility and utility of methacholme airway responsivenes in studies of allergen-induced asthma. Am J Respir Crit Care Med 1996, 153:A623.
    • (1996) Am J Respir Crit Care Med , vol.153
    • Inman, M.D.1    Watson, R.2    O'Byrne, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.