Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): Is LRP central to Alzheimer's disease pathogenesis?

Molecular and Cellular Neurosciences

Volumn 14, Issue 2, 1999, Pages 129-140

  Van Uden, Emily ^a   Carlson, George ^c   St George Hyslop, Peter ^d   Westaway, David ^d   Orlando, Robert ^b   Mallory, Margaret ^a   Rockenstein, Edward ^a   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; PRESENILIN 1; RECEPTOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; DISEASE PREDISPOSITION; DOWN REGULATION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; TISSUE DISTRIBUTION;

EID: 0032862858     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1999.0772     Document Type: Article

References (60)

1. Ang L. C., Shul D. D. Peptidergic neurons of subcortical white matter in aging and Alzheimer's brain. Brain Res. 674:1995;329-335.
2. Aoyagi T., Wada T., Kojima F., Nagai M., Harada S., Takeuchi T., Isse K., Ogura M., Hamamoto M., Tanaka K. Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia. Experientia. 48:1992;656-659.
3. Blacker D., Wilcox M. A., Laird N. M., Rodes L., Horvath S. M., Go R. C., Perry R., Watson B. Jr., Bassett S. S., McInnis M. G., Albert M. S., Hyman B. T., Tanzi R. E. Alpha-2 macroglobulin is genetically associated with Alzheimer disease [see Comments]. Nat. Gen. 19:1998;357-360.
4. Borchelt D. R., Thinakaran G., Eckman C. B., Lee M. K., Davenport F., Ratovitsky T., Prada C. M., Kim G., Seekins S., Yager D., Slunt H. H., Wang R., Seeger M., Levey A. I., Gandy S. E., Copeland N. G., Jenkins N. A., Price D. L., Younkin S. G., Sisodia S. S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta 1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
5. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St George Hyslop P., Selkoe D. J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice [see Comments]. Nat. Med. 3:1997;67-72.
6. Clark R. F., Hutton M., Talbot C., Wragg M., Lendon C., Busfield F., Han S. W., Perez-Tur J., Adams M., Fuldner R., Roberts G., Karran E., Hardy J., Goate A. The role of presenilin 1 in the genetics of Alzheimer's disease. Cold Spring Harb. Symp. Quant. Biol. 61:1996;551-558.
7. Czekay R. P., Orlando R. A., Woodward L., Adamson E. D., Farquhar M. G. The expression of megalin (gp330) and LRP diverges during F9 cell differentiation. J. Cell Sci. 108:1995;1433-1441.
8. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391:1998;387-390.
9. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J. S., Schroeter E. H., Schrijvers V., Wolfe M. S., Ray W. J., Goate A., Kopan R. A presenilin-1-dependent gamma-secretase-like protein mediates release of Notch intracellular domain. Nature. 398:1999;518-522.
10. Dournaud P., Cervera-Pierot P., Hirsch E., Javoy-Agid F., Kordon C., Agid Y., Epelbaum J. Somatostatin messenger RNA-containing neurons in Alzheimer's disease: An in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. Neuroscience. 61:1994;755-764.
11. Duff K., Eckman C., Zehr C., Yu X., Prada C. M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M. N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-beta 42 and 43 in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
12. Elder G. A., Tezapsidis N., Carter J., Shioi J., Bouras C., Li H. C., Johnston J. M., Efthimiopoulos S., Friedrich V. L. Jr., Robakis N. K. Identification and neuron-specific expression of the S182/presenilin I protein in human and rodent brains. J. Neurosci. Res. 45:1996;308-320.
13. Fagan A. M., Bu G., Sun Y., Daugherty A., Holtzman D. M. Apolipoprotein E-containing high-density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271:1996;30121-30125.
14. Finch C. E., Tanzi R. E. Genetics of aging. Science. 278:1997;407-411.
15. Furukawa K., Guo Q., Schellenberg G. D., Mattson M. P. Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells. J. Neurosci. Res. 52:1998;618-624.
16. Haass C. Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease. Curr. Opin. Neurol. 9:1996;254-259.
17. Herz J., Willnow T. E. Lipoprotein and receptor interactions in vivo. Curr. Opin. Lipidol. 6:1995;97-103.
18. Holtzman D. M., Pitas R. E., Kilbridge J., Nathan B., Mahley R. W., Bu G., Schwartz A. L. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. USA. 92:1995;9480-9484.
19. Huynh D. P., Ho V. V., Pulst S. M. Characterization and expression of presenilin 1 in mouse brain. Neuroreport. 7:1996;2423-2428.
20. Kang D. E., Saitoh T., Chen X., Xia Y., Masliah E., Hansen L. A., Thomas R. G., Thal L. J., Katzman R. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology. 49:1997;56-61.
21. Kim K. S., Wegiel J., Sapienza V., Chen J., Hong H., Wisniewski H. M. Immunoreactivity of presenilin-1 in human, rat and mouse brain. Brain Res. 757:1997;159-163.
22. Knauer M. F., Orlando R. A., Glabe C. G. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Res. 740:1996;6-14.
23. Kounnas M. Z., Moir R. D., Rebeck G. W., Bush A. I., Argraves W. S., Tanzi R. E., Hyman B. T., Strickland D. K. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 82:1995;331-340.
24. Kuchenhoff A., Harrach-Ruprecht B., Robeneck H. Interaction of apo E-containing lipoproteins with the LDL receptor-related protein LRP. Am. J. Physiol. 272:1997;C369-C382.
25. Lah J. J., Heilman C. J., Nash N. R., Rees H. D., Yi H., Counts S. E., Levey A. I. Light and electron microscopic localization of presenilin-1 in primate brain. J. Neurosci. 17:1997;1971-1980.
26. Lee M. K., Slunt H. H., Martin L. J., Thinakaran G., Kim G., Gandy S. E., Seeger M., Koo E., Price D. L., Sisodia S. S. Expression of PS-1 and PS2 in human and murine tissues. J. Neurosci. 16:1996;7513-7525.
27. Lemere C. A., Lopera F., Kosik K. S., Lendon C. L., Ossa J., Saido T. C., Yamaguchi H., Ruiz A., Martinez A., Madrigal L., Hincapie L., Arango J. C., Anthony D. C., Koo E. H., Goate A. M., Selkoe D. J., Arango J. C. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat. Med. 2:1996;1146-1150.
28. Lendon C. L., Talbot C. J., Craddock N. J., Han S. W., Wragg M., Morris J. C., Coate A. M. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neurosci. Lett. 222:1997;187-190.
29. Licastro F., Morini M. C., Polazzi E., Davis L. J. Increased serum alpha1-antichymotrypsin in patients with probable Alzheimer's disease: An acute phase reactant without the peripheral acute phase response. J. Neuroimmunol. 57:1995;71-75.
30. Lopes M. B., Bogaev C. A., Gonias S. L., VandenBerg S. R. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells. FEBS Lett. 338:1994;301-305.
31. Mann D. M., Iwatsubo T., Cairns N. J., Lantos P. L., Nochlin D., Sumi S. M., Bird T. D., Poorkaj P., Hardy J., Hutton M., Prihar G., Crook R., Rossor M. N., Haltia M. Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Ann. Neurol. 40:1996;149-156.
32. Martins R. N., Turner B. A., Carroll R. T., Sweeney D., Kim K. S., Wisniewski H. M., Blass J. P., Gibson G. E., Gandy S. High levels of amyloid-beta protein from S182 Glu246 familial Alzheimer's cells. Neuroreport. 7:1995;217-220.
33. Masliah E., Mallory M., Hansen L., DeTeresa R., Alford M., Terry R. Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neurosci. Lett. 174:1990;67-72.
34. Masliah E., Terry R. D., Mallory M., Alford M., Hansen L. A. Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am. J. Pathol. 137:1990;1293-1297.
35. Masliah E. Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol. Histopathol. 10:1995a;509-519.
36. Masliah E., Mallory M., Alford M., Deteresa R., Saitoh T. PDGF is associated with neuronal and glial alterations of Alzheimer's disease. Neurobiol. Aging. 16:1995b;549-556.
37. Mehta N. D., Refolo L. M., Eckman C., Sanders S., Yager D., Perez-Tur J., Younkins S., Duff K., Hardy J., Hutton M. Increased Abeta42(43) from cell lines expressing presenilin 1 mutations. Ann. Neurol. 43:1998;256-258.
38. Moussaoui S., Czech C., Pradier L., Blanchard V., Bonici B., Gohin M., Imperato A., Revah F. Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Lett. 383:1996;219-222.
39. Murayama M., Tanaka S., Palacino J., Murayama O., Honda T., Sun X., Yasutake K., Nihonmatsu N., Wolozin B., Takashima A. Direct association of presenilin-1 with beta-catenin. FEBS Lett. 433:1998;73-77.
40. Narita M., Bu G., Holtzman D. M., Schwartz A. L. The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor modulates hippocampal neurite development. J. Neurochem. 68:1997a;587-595.
41. Narita M., Holtzman D. M., Schwartz A. L., Bu G. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J. Neurochem. 69:1997b;1904-1911.
42. Okada S. S., Grobmyer S. R., Barnathan E. S. Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion. Arterioscler. Thromb. Vasc. Biol. 16:1996;1269-1276.
43. Orlando R. A., Farquhar M. G. Identification of a cell line that expresses a cell surface and soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex. Proc. Natl. Acad. Sci. USA. 90:1993;4082-4086.
44. Rebeck G. W., Harr S. D., Strickland D. K., Hyman B. T. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann. Neurol. 37:1995;211-217.
45. Rockenstein E. M., McConlogue L., Tan H., Power M., Masliah E., Mucke L. Levels and alternative splicing of amyloid β protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J. Biol. Chem. 270:1995;28257-28267.
46. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T. D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [see Comments]. Nat. Med. 2:1996;864-870.
47. Scott M. R., Köhler R., Foster D., Prusiner S. B. Chimeric prion protein expression in cultured cells and transgenic mice. Protein Sci. 1:1992;986-997.
48. Strickland D. K., Kounnas M. Z., Argraves W. S. LDL receptor-related protein: A multiligand receptor for lipoprotein and proteinase catabolism. Faseb J. 9:1995;890-898.
49. Tan Y., Hong J., Doan T., McConlogue L., Maltese W. A. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus. Biochim. Biophys. Acta. 1407:1998;69-78.
50. Uchihara T., Hachimi H. K., Duyckaerts C., Foncin J. F., Fraser P. E., Levesque L., St. George-Hyslop P. H., Hauw J. J. Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: Double-labeling immunohistochemical study. Acta Neuropathol. 92:1996;325-330.
51. Van Uden E., Masliah E. A novel role for receptor-associated protein in somatostatin modulation: implications for Alzheimer's disease. Neuroscience. 88:1999;687-700.
52. Waragai M., Imafuku I., Takeuchi S., Kanazawa I., Oyama F., Udagawa Y., Kawabata M., Okazawa H. Presenilin 1 binds to amyloid precursor protein directly. Biochem. Biophys. Res. Commun. 239:1997;480-482.
53. Wavrant-DeVrieze F., Perez-Tur J., Lambert J. C., Frigard B., Pasquier F., Delacourte A., Amouyel P., Hardy J., Chartier-Harlin M. C. Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease. Neurosci. Lett. 227:1997;68-70.
54. Weaver A. M., Hussaini I. M., Mazar A., Henkin J., Gonias S. L. Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin. J. Biol. Chem. 272:1997;14372-14379.
55. Weidemann A., Paliga K., Dürrwang U., Czech C., Evin G., Masters C. L., Beyreuther K. Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein. Nature Med. 3:1997;328-332.
56. Wijnberg M. J., Quax P. H., Nieuwenbroek N. M., Verheijen J. H. The migration of human smooth muscle cells in vitro is mediated by plasminogen activation and can be inhibited by alpha2-macroglobulin receptor associated protein. Thrombo. Haemo. 78:1997;880-886.
57. Williams S. E., Kounnas M. Z., Argraves K. M., Argraves W. S., Strickland D. K. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the receptor-associated protein. An overview. Ann. N.Y. Acad. Sci. 737:1994;1-13.
58. Wolfe M. S., Xia W. M., Ostaszewski B. L., Diehl T. S., Kimberly W. T., Selkoe D. J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398:1999;513-517.
59. Xia W., Zhang J., Kholodenko D., Citron M., Podlisny M. B., Teplow D. B., Haass C., Seubert P., Koo E. H., Selkoe D. J. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272:1997;7977-7982.
60. Zhang J., Kang D. E., Xia W., Okochi M., Mori H., Selkoe D. J., Koo E. H. Subcellular distribution and turnover of presenilins in transfected cells. J. Biol. Chem. 273:1998;12436-12442.