The migration of human smooth muscle cells in vitro is mediated by plasminogen activation and can be inhibited by α2-macroglobulin receptor associated protein

Thrombosis and Haemostasis

Volumn 78, Issue 2, 1997, Pages 880-886

  Wijnberg, Monique J ^a   Quax, Paul H A ^a   Nieuwenbroek, Nancy M E ^a   Verheijen, Jan H ^a  

^a TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; CELL SURFACE RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PLASMIN; PLASMINOGEN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ARTICLE; CELL MIGRATION; FEMALE; FETUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

EID: 0030878223     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1657646     Document Type: Article

References (48)

1. Casscells W. Migration of smooth muscle and endothelial cells - critical events in restenosis. Circulation 1992; 86: 723-9.
2. O'Brien ER, Schwartz SM. Update on the biology and clinical study of restenosis. Trends Cardiovasc Med 1994; 4: 169-78.
3. Vassalli JD, Sappino, AP, Belin D. The plasminogen activator/plasmin system. J Clin Invest 1991; 88: 1067-72.
4. Pepper MS, Belin D, Montesano R, Orci L, Vassalli JD. Transforming growth factor-beta-1 modulates basic fibroblast growth factor induced proteolytic and angiogenic properties of endothelial cells invitro. J Cell Biol 1990; 111: 743-55.
5. Pepper MS, Sappino AP, Stocklin R, Montesano R, Orci L, Vassalli JD. Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol 1993; 122: 673-84.
6. Clowes AW, Clowes MM, Au YPT, Reidy MA, Belin D. Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 1990; 67: 61-7.
7. Blasi F. Urokinase and urokinase receptor - a paracrine/autocrine system regulating cell migration and invasiveness. BioEssays 1993; 15: 105-11.
8. Vassalli JD, Baccino D, Belin D. A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase. J Cell Biol 1985; 100: 86-92.
9. Stoppelli MP, Corti A, Soffientini A, Cassani G, Blasi F, Associan RK. Differentiation enhanced binding of the amino terminal fragment of human urokinase-type plasminogen activator to a specific receptor on U937 monocytes. Proc Natl Acad Sci USA 1985; 82: 4939-43.
10. Cubellis MV, Wun TC, Blasi F. Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J 1990; 9: 1079-85.
11. Estreicher A, Muhlhauser J, Carpentier JL, Orci L, Vassalli JD. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 1990; 111: 783-92.
12. Blasi F, Conese M, Moller LB, Pedersen N, Cavallaro U, Cubellis MV, Fazioli F, Hernandezmarrero L, Limongi P, Munozcanoves P, Resnati M, Riittinen L, Sidenius N, Soravia E, Soria MR, Stoppelli MP, Talarico D, Teesalu T, Valcamonica S. The urokinase receptor: structure, regulation and inhibitor-mediated internalization. Fibrinolysis 1994; 8 suppl.1: 182-8.
13. Danø K, Behrendt N, Brunner N, Ellis V, Ploug M, Pyke C. The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion. Fibrinolysis 1994; 8 suppl.1: 189-203.
14. Vassalli JD. The urokinase receptor. Fibrinolysis 1994; 8 suppl. 1: 172-81.
15. 2-Macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem 1992; 267: 14543-6.
16. Heegaard CW, Wiborg Simonsen AC, Oka K, Kjøller L, Christensen A, Madsen B, Ellgaard L, Chan L, Andreasen PA. Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex. J Biol Chem 1995; 270: 20855-61.
17. Strickland DK, Kounnas MZ, Williams SE, Argraves WS. LDL receptor-related protein (LRP): a multiligand receptor. Fibrinolysis 1994; 8 suppl. 1: 204-215.
18. 2-macroglobulin receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands. Biochim Biophys Acta 1994; 1197: 197-213.
19. Conese M, Nykjaer A, Petersen CM, Cremona O, Pardi R, Andreasen PA, Gliemann J, Christensen EI, Blasi F. Alpha-2 Macroglobulin receptor/Ldl receptor-related protein (Lrp)-dependent internalization of the urokinase receptor. J Cell Biol 1995; 131: 1609-22.
20. Grobmyer SR, Kuo A, Orishimo M, Okada SS, Cines DB, Barnathan ES. Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells. J Biol Chem 1993; 268: 13291-300.
21. Ossowski L, Clunie G, Masucci MT, Blasi F. In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Biol 1991; 115: 1107-12.
22. Quax PHA, Pedersen N, Masucci MT, Weening-Verhoeff EJD, Danø K, Verheijen JH, Blasi F. Complementation between urokinase-producing and receptor producing cells in extracellular matrix degradation. Cell Regul 1991; 2: 793-803.
23. Quax PHA, Boxman ILA, Van Kesteren CAM, Verheijen JH, Ponec M. Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultures in vitro. Fibrinolysis 1994; 8: 221-8.
24. Koolwijk P, Vanerck MGM, Devree WJA, Vermeer MA, Weich HA, Hanemaaijer R, Vanhinsbergh VWM. Cooperative effect of TNF alpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity. J Cell Biol 1996; 122: 673-84.
25. Schleef RR, Birdwell CR. The effects of proteases on endothelial cell migration in vitro. Exp Cell Res 1982; 141: 503-8.
26. Jackson CL, Raines EW, Ross R, Reidy MA. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arterioscl Thromb 1993; 13: 1218-26.
27. Carmeliet P, Collen D. Evaluation of the plasminogen/plasmin system in transgenic mice. Fibrinolysis 1994; 8 suppl. 1: 269-76.
28. Carmeliet P, Moons L, Dewerchin M, Ploplis V, De Mol M, Stassen JM, Declerq C, Plow E, Gerard R, Collen D. Receptor-independent plasminogen activation by urokinase-type plasminogen activator promotes, and adenoviral PAI-1 gene transfer inhibits arterial neointima formation in mice. Fibrinolysis 1996; 10 suppl. 3: 19.
29. Noda-Heiny H, Daugherty A, Sobel BE. Augmented urokinase receptor expression in atheroma. Arterioscler Thromb Vasc Biol 1995; 15: 37-43.
30. 2-macroglobulin receptor in human normal and atherosclerotic arteries. Arteriocler Thromb 1994; 14: 1438-44.
31. Lupu F, Heim DA, Bachmann F, Hurni M, Kakkar VV, Kruithof EKO. Plasminogen activator expression in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol 1995; 15: 1444-55.
32. Raghunath PN, Tomaszewski JE, Brady ST, Caron RJ, Okada SS, Barnathan ES. Plasminogen activator system in human coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1995; 15: 1432-43.
33. Padró T, Emeis JJ, Steins M, Schmid KW, Kienast J. Quantification of plasminogen activators and their inhibitors in the aortic vessel wall in relation to the presence and severity of atherosclerotic disease. Arterioscler Thromb Vasc Biol 1995; 15: 893-902.
34. Wijnberg MJ, Nieuwenbroek NME, Slomp J, Quax PHA, Verheijen JH. Urokinase and tissue-type plasminogen activator stimulate human vascular smooth muscle cell migration. Fibrinolysis 1996; 10 suppl. 2: 75-8.
35. Jaffe EA, Nachmann RL, Becker CG. Culture of endothelial cells derived from umbilical veins - Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52: 2745-56.
36. Kocan RM, Moss NS, Benditt EP. Human arterial wall cells and tissues in culture. Methods in Cell Biology 1980; 21A: 153-66.
37. Rijken DC, Wijngaards G, Welbergen J. Immunological characterization of plasminogen activator activities in human tissues and body fluids. J Lab Clin Med 1981; 97: 477-86.
38. Binnema DJ, Van Iersel JJL, Dooijewaard G. Quantitation of urokinase antigen in plasma and culture media by use of an ELISA. Thromb Res 1986; 43: 569-77.
39. Chucholowski N, Schmitt M, Rettenberger D, Schuren E, Moniwa N, Goretzki L, Wilhelm O, Weidle U, Janicke F, Graeff H. Flow cytofluorometric analysis of the urokinase receptor (uPAR) on tumor cells by fluorescent uPA-ligand or monoclonal antibody 3936. Fibrinolysis 1992; 6 suppl. 4: 95-102.
40. Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 1988; 7: 4119-27.
41. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-7.
42. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
43. Granelli-Piperno A, Reich E. A study of proteases and protease inhibitor complexes in biological fluids. J Exp Med 1978; 148: 223-34.
44. Sperti G, Van Leeuwen RTJ, Quax PHA, Maseri A, Kluft C. Cultured rat aortic vascular smooth muscle cells digest naturally produced extracellular matrix. Involvement of plasminogcn-dependent and plasminogen-independent pathways. Circ Res 1992; 71: 385-92.
45. Pauly RR, Passaniti A, Bilato C, Monticone R, Cheng L, Papadopoulos N, Gluzland YA, Smith L, Weinstein C, Lakatta EG, Crow MT. Migration of cultured vascular smooth muscle cells through a basement membrane requires type IV collagenase activity and is inhibited by cellular differentiation. Circ Res 1994; 75: 41-54.
46. Bendeck M, Zempo N, Clowes MM, Galardy R, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res 1994; 75: 539-45.
47. Okada SS, Tomaszewski JE, Barnathan ES. Migrating vascular smooth muscle cells polarize cell surface urokinase receptors after injury in vitro. Exp Cell Res 1995; 217: 180-7.
48. Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg J, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 1994; 269: 32380-8.