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Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia
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Pui C-H, Rubnitz JE, Hancock ML, Downing JR, Raimondi SC, Rivera GK, et al.: Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia. J Clin Oncol 1998, 16:3768-3773.
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Takahashi Y, Horibe K, Kiyoi H, Miyashita Y, Fukuda M, Mori H, et al.: Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia. J Pediatr Hematol Oncol 1998, 20:190-195.
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7
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TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia
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for the Berlin-Frankfurt-Munster Study Group
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Seeger K, Adams HP, Buchwald D, Beyermann B, Kremens B, Niemeyer C, et al., for the Berlin-Frankfurt-Munster Study Group: TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia. Blood 1998, 91:1716-1722.
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8
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Loh ML, Silverman LB, Young ML, Neuberg D, Golub TR, Sallan SE, Gilliland DG: Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia. Blood 1998, 92:4792-4797.
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9
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Rubnitz JE, Behm FG, Wichlan D, Ryan C, Sandlund JT, Ribeiro RC, et al.: Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup. Leukemia 1999, 13:19-21.
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Pui C-H, Evans WE: Acute lymphoblastic leukemia. N Engl J Med 1998, 339:605-614. This review summarizes recent advances in both the characterization of leukemic cells and the treatment of ALL.
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Uckun FM, Sensel MG, Sather HN, Gaynon PS, Arthur DC, Lange BJ, et al.: Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group. J Clin Oncol 1998, 16:527-535.
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Hunger SP, Fall MZ, Camitta BM, Carroll AJ, Link MP, Lauer SJ, et al.: E2A-PBX1 chimeric transcript status at end of consolidation is not predictive of treatment outcome in childhood acute lymphoblastic leukemias with a t(1;19)(q23;p13): a Pediatric Oncology Group study. Blood 1998, 91: 1021-1028.
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Uckun FM, Nachman JB, Sather HN, Sensel MG, Kraft P, Steinherz PG, et al.: Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group. Cancer 1998, 83:2030-2039.
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Johansson B, Moorman AV, Haas OA, Watmore AE, Cheung KL, Swanton S, Secker-Walker LM: Hematologic malignancies with t(4;11)(q21;q23)-a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. Leukemia 1998, 12:779-787. The finding of a favorable prognosis of children two to nine years of age with the t(4;11) confirms the results of our previous study (Pui et al., Blood 1991, 77:440-447), and supports our notion that that the indication of allogeneic HSCT should not be based solely on genetic abnormalities.
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Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM: The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. Leukemia 1998, 12:805-810.
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Lillington DM, Young BD, Berger R, Martineau M, Moorman AV, Secker-Walker LM, and the European 11q23 Workshop participants: The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients. Leukemia 1998, 12:801-804.
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Swansbury GJ, Slater R, Bain BJ, Moorman AV, Secker-Walker LM, and the European 11q23 Workshop participants: Hematological malignancies with t(9;11)(p21-22;q23)-a laboratory and clinical study of 125 cases. Leukemia 1998, 12:792-800.
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Martineau M, Berger R, Lillington DM, Moorman AV, Secker-Walker LM, and the European Concerted Action 11q23 Workshop participants: The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical study of 30 cases. Leukemia 1998, 12:788-791.
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Hunger SP, McGavran L, Meltesen L, Parker NB, Kassenbrock CK, Bitter MA: Oncogenesis in utero: fetal death due to acute myelogenous leukaemia with an MLL translocation. Br J Haematol 1998, 103:539-542.
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Ludwig WD, Rieder H, Bartram CR, Heinze B, Schwartz S, Gassmann W, et al.: Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89. Blood 1998, 92:1898-1909. The addition of high-dose cytarabine and mitoxantrone to standard therapy eliminated the prognostic impact of the t(4;11) among adult patients with pro-B ALL. In this study, the probability of CCR for patients with t(4;11)/MLL-AF4 did not differ significantly with the probability of remission for those patients without this genetic abnormality.
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Rubnitz JE, Camitta BM, Mahmoud H, Raimondi SC, Carroll AJ, Borowitz MJ, et al.: Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation. J Clin Oncol 1999, 17:191-196. The MLL-ENL fusion was associated with a favorable outcome for B-precursor patients one to 10 years of age and for T-cell patients. No relapses occurred in these patient subgroups.
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for the European Organization for Research and Treatment of Cancer-Childhood Leukemia Cooperative Group
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Cave H, van der Werff ten Bosch, Suciu S, Guidal C, Waterkeyn C, Otten J, et al., for the European Organization for Research and Treatment of Cancer-Childhood Leukemia Cooperative Group: Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. N Engl J Med 1998, 339:591-598. In this study of 178 children with ALL, the presence and level of MRD at four time points were predictive of survival. A multivariate analysis that included immunophenotype, age, and leukocyte count at the time of diagnosis showed that residual disease was the most important prognostic factor.
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Uckun FM, Herman-Hatten K, Crotty ML, Sensel MG, Sather HN, Tuel-Ahlgren L, et al.: Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation. Blood 1998, 92:810-821.
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